{"id":"https://openalex.org/W2068949869","doi":"https://doi.org/10.1067/s0039-6060(03)00253-8","title":"The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A","display_name":"The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2068949869","doi":"https://doi.org/10.1067/s0039-6060(03)00253-8","mag":"2068949869","pmid":"https://pubmed.ncbi.nlm.nih.gov/14555936"},"language":"en","primary_location":{"id":"doi:10.1067/s0039-6060(03)00253-8","doi":"https://doi.org/10.1067/s0039-6060(03)00253-8","is_oa":false,"landing_page_url":"https://doi.org/10.1067/s0039-6060(03)00253-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210173306","display_name":"Surgery","issn_l":"0039-6060","issn":["0039-6060","1532-7361"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059024017","display_name":"Frederick D Reynolds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick D Reynolds","raw_affiliation_strings":["Department of Surgery, the Mary Imogene Bassett Hospital, Cooperstown, NY 13326, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, the Mary Imogene Bassett Hospital, Cooperstown, NY 13326, USA","institution_ids":["https://openalex.org/I4210156573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108445496","display_name":"Robert T. Dauchy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Dauchy","raw_affiliation_strings":["From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA","institution_ids":["https://openalex.org/I4210156573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016402426","display_name":"David E. Blask","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Blask","raw_affiliation_strings":["From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA","institution_ids":["https://openalex.org/I4210156573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049425709","display_name":"Patrick A. Dietz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A Dietz","raw_affiliation_strings":["From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA","institution_ids":["https://openalex.org/I4210156573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052907067","display_name":"Darin T. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darin Lynch","raw_affiliation_strings":["From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA","institution_ids":["https://openalex.org/I4210156573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110015274","display_name":"Randall S. Zuckerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156573","display_name":"Bassett Medical Center","ror":"https://ror.org/05fk0de79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210155413","https://openalex.org/I4210156573"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall Zuckerman","raw_affiliation_strings":["From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and the Laboratory of Experimental Neuroendocrinology/Oncology, the Mary Imogene Bassett Hospital, Cooperstown, NY, USA","institution_ids":["https://openalex.org/I4210156573"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110015274"],"corresponding_institution_ids":["https://openalex.org/I4210156573"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.454,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.52251281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"134","issue":"3","first_page":"474","last_page":"479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5737000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.8870000243186951},{"id":"https://openalex.org/keywords/zymosan-a","display_name":"zymosan A","score":0.9909999966621399},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9160000085830688},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/spleen-weight","display_name":"spleen weight","score":0.7929999828338623},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.34299999475479126},{"id":"https://openalex.org/keywords/photoperiod","display_name":"photoperiod","score":0.671999990940094},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9267051815986633},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.8944598436355591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7657706141471863},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6547888517379761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6537970304489136},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5853372812271118},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5505151152610779},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5407332181930542},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44549301266670227},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.44176825881004333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15778502821922302},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009102","descriptor_name":"Multiple Organ Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015054","descriptor_name":"Zymosan","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1067/s0039-6060(03)00253-8","doi":"https://doi.org/10.1067/s0039-6060(03)00253-8","is_oa":false,"landing_page_url":"https://doi.org/10.1067/s0039-6060(03)00253-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210173306","display_name":"Surgery","issn_l":"0039-6060","issn":["0039-6060","1532-7361"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"journal-article"},{"id":"pmid:14555936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14555936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W178417438","https://openalex.org/W1540874939","https://openalex.org/W1589377963","https://openalex.org/W1913186869","https://openalex.org/W1972656444","https://openalex.org/W1974417554","https://openalex.org/W1977427213","https://openalex.org/W1984692518","https://openalex.org/W1985829379","https://openalex.org/W1987508889","https://openalex.org/W1996148507","https://openalex.org/W1998458964","https://openalex.org/W1998713395","https://openalex.org/W2006392521","https://openalex.org/W2006761570","https://openalex.org/W2011151958","https://openalex.org/W2019993857","https://openalex.org/W2020709143","https://openalex.org/W2023119268","https://openalex.org/W2024376535","https://openalex.org/W2025996043","https://openalex.org/W2028707772","https://openalex.org/W2032779870","https://openalex.org/W2053246203","https://openalex.org/W2056339655","https://openalex.org/W2060971930","https://openalex.org/W2062708982","https://openalex.org/W2063995961","https://openalex.org/W2068349992","https://openalex.org/W2070720353","https://openalex.org/W2077198366","https://openalex.org/W2079561932","https://openalex.org/W2080712306","https://openalex.org/W2085651394","https://openalex.org/W2087683926","https://openalex.org/W2103900944","https://openalex.org/W2117629620","https://openalex.org/W2119541227","https://openalex.org/W2144757596","https://openalex.org/W2153503299","https://openalex.org/W2154686833","https://openalex.org/W2155679235","https://openalex.org/W2171273651","https://openalex.org/W2243572961","https://openalex.org/W2320413839","https://openalex.org/W2396745275","https://openalex.org/W3216624875"],"related_works":["https://openalex.org/W1985229675","https://openalex.org/W1987508889","https://openalex.org/W2059220837","https://openalex.org/W1984692518","https://openalex.org/W2043569138","https://openalex.org/W7058039665","https://openalex.org/W1985021728","https://openalex.org/W4309969645","https://openalex.org/W4401352799","https://openalex.org/W2773024908"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}