{"id":"https://openalex.org/W2068931925","doi":"https://doi.org/10.1002/hep.21312","title":"Interleukin\u201029 uses a type 1 interferon\u2010like program to promote antiviral responses in human hepatocytes\u2020","display_name":"Interleukin\u201029 uses a type 1 interferon\u2010like program to promote antiviral responses in human hepatocytes\u2020","publication_year":2006,"publication_date":"2006-09-27","ids":{"openalex":"https://openalex.org/W2068931925","doi":"https://doi.org/10.1002/hep.21312","mag":"2068931925","pmid":"https://pubmed.ncbi.nlm.nih.gov/17006906"},"language":"en","primary_location":{"id":"doi:10.1002/hep.21312","doi":"https://doi.org/10.1002/hep.21312","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.21312","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039274901","display_name":"Sean E. Doyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120229","display_name":"Seagen (Canada)","ror":"https://ror.org/01txmfh60","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210120229","https://openalex.org/I99319750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sean E. Doyle","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA 98102, USA","ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA 98102, USA","institution_ids":["https://openalex.org/I4210120229"]},{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066511734","display_name":"Heidi Schreckhise","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heidi Schreckhise","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013095503","display_name":"Kien Khuu-Duong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kien Khuu\u2010Duong","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013804656","display_name":"Katherine Henderson","orcid":"https://orcid.org/0000-0001-8682-5051","observed_orcids":["https://orcid.org/0000-0001-8682-5051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine Henderson","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054365671","display_name":"Robert Rosler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Rosler","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Harold Storey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harold Storey","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008345546","display_name":"Lena Yue Yao","orcid":"https://orcid.org/0000-0002-2131-6149","observed_orcids":["https://orcid.org/0000-0002-2131-6149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lena Yao","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410334","display_name":"Hong Liu","orcid":"https://orcid.org/0000-0002-8926-1308","observed_orcids":["https://orcid.org/0000-0002-8926-1308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Liu","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050318405","display_name":"Fariba Barahmand-Pour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fariba Barahmand\u2010pour","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112104233","display_name":"Pallavur V. Sivakumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pallavur Sivakumar","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102282454","display_name":"Chung Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chung Chan","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072566839","display_name":"Carl Birks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Birks","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111842926","display_name":"Don Foster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Don Foster","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067627872","display_name":"Christopher H. Clegg","orcid":"https://orcid.org/0000-0003-3765-1862","observed_orcids":["https://orcid.org/0000-0003-3765-1862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher H. Clegg","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047813711","display_name":"Perdita Wietzke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Perdita Wietzke\u2010Braun","raw_affiliation_strings":["Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Georg-August-Universitat, Gottingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Georg-August-Universitat, Gottingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023994396","display_name":"Sabine Mihm","orcid":"https://orcid.org/0000-0002-9629-4538","observed_orcids":["https://orcid.org/0000-0002-9629-4538"]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Mihm","raw_affiliation_strings":["Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Georg-August-Universitat, Gottingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Georg-August-Universitat, Gottingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033878540","display_name":"Kevin M. Klucher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kevin M. Klucher","raw_affiliation_strings":["ZymoGenetics, Inc., Seattle, WA","fax: 206-442-6608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ZymoGenetics, Inc., Seattle, WA","institution_ids":[]},{"raw_affiliation_string":"fax: 206-442-6608","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033878540"],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":4.1624,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.94791422,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"44","issue":"4","first_page":"896","last_page":"906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-29","display_name":"IL-29","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-28","display_name":"IL-28","score":0.7649999856948853},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7789999842643738},{"id":"https://openalex.org/keywords/antiviral-response","display_name":"antiviral response","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/stat2","display_name":"STAT2","score":0.6769999861717224},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8730000257492065},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.9869999885559082},{"id":"https://openalex.org/keywords/2-5-oligoadenylate-synthetase","display_name":"2',5'-oligoadenylate synthetase","score":0.871999979019165},{"id":"https://openalex.org/keywords/mx1","display_name":"MX1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":1.0},{"id":"https://openalex.org/keywords/west-nile-virus","display_name":"West Nile virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-viral-hepatitis","display_name":"chronic viral hepatitis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6429721117019653},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.6310122609138489},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5630649924278259},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.53737473487854},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5314886569976807},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5145920515060425},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.445298433303833},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.4251471757888794},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41650527715682983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3829386532306671},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3581792116165161},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31549888849258423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12260875105857849},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.10715183615684509},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000095022","descriptor_name":"Interferon Lambda","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005416","descriptor_name":"Flavivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006525","descriptor_name":"Hepatitis, Viral, Human","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006525","descriptor_name":"Hepatitis, Viral, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/hep.21312","doi":"https://doi.org/10.1002/hep.21312","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.21312","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:17006906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17006906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/26535","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/26535","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1483065389","https://openalex.org/W1517770332","https://openalex.org/W1983974405","https://openalex.org/W1987009823","https://openalex.org/W1989943607","https://openalex.org/W1991440322","https://openalex.org/W1997229470","https://openalex.org/W2004837207","https://openalex.org/W2005759537","https://openalex.org/W2006943910","https://openalex.org/W2017896938","https://openalex.org/W2027545702","https://openalex.org/W2045109947","https://openalex.org/W2048040167","https://openalex.org/W2048699176","https://openalex.org/W2049332203","https://openalex.org/W2051014917","https://openalex.org/W2055399127","https://openalex.org/W2058243648","https://openalex.org/W2076321236","https://openalex.org/W2076733264","https://openalex.org/W2078887917","https://openalex.org/W2083684518","https://openalex.org/W2083802827","https://openalex.org/W2085237060","https://openalex.org/W2087391661","https://openalex.org/W2089738808","https://openalex.org/W2095224028","https://openalex.org/W2103565638","https://openalex.org/W2107277218","https://openalex.org/W2123628070","https://openalex.org/W2128338137","https://openalex.org/W2131733302","https://openalex.org/W2141130362","https://openalex.org/W2157135427","https://openalex.org/W2160063406","https://openalex.org/W2166045485","https://openalex.org/W2169631718","https://openalex.org/W2317554121","https://openalex.org/W2332630894","https://openalex.org/W2333452860","https://openalex.org/W2335684552","https://openalex.org/W2341203768","https://openalex.org/W2412510649","https://openalex.org/W2418494117","https://openalex.org/W2497059924","https://openalex.org/W2531646094","https://openalex.org/W3149727786","https://openalex.org/W6716988686"],"related_works":["https://openalex.org/W2045882981","https://openalex.org/W2728720771","https://openalex.org/W1970451495","https://openalex.org/W2317927426","https://openalex.org/W1977710208","https://openalex.org/W2165997070","https://openalex.org/W2063683957","https://openalex.org/W2392290474","https://openalex.org/W2531804754","https://openalex.org/W2138079286"],"abstract_inverted_index":{"Interleukin-28A":[0],"(IL-28A),":[1],"IL-28B":[2],"and":[3,52,66,74,77,107,112,120,139,146,163],"IL-29":[4,51,96,111,129,162,188],"are":[5],"a":[6,17,132],"family":[7,37],"of":[8,38,63,68,81,110,172],"class":[9],"II":[10],"cytokines":[11,39,59],"that":[12,20,57,187],"stimulate":[13,60,165],"antiviral":[14,42,167],"responses":[15,48,168],"through":[16],"heterodimeric":[18],"receptor":[19,97,180],"is":[21,98],"distinct":[22,88],"from":[23],"the":[24,41,95,148,153],"type":[25],"I":[26],"interferon":[27],"(IFN)":[28],"receptor.":[29],"To":[30],"better":[31],"understand":[32],"how":[33],"this":[34,125],"newly":[35],"described":[36],"regulates":[40],"state,":[43],"we":[44,55],"compared":[45],"various":[46],"cellular":[47],"elicited":[49],"by":[50,91,152],"IFN-alpha.":[53],"Here":[54],"show":[56],"these":[58],"similar":[61],"patterns":[62,80],"signal":[64],"transducer":[65],"activator":[67],"transcription":[69],"1":[70],"(STAT-1),":[71],"-2,":[72],"-3,":[73],"-5":[75],"phosphorylation":[76],"nearly":[78],"identical":[79,166],"gene":[82,122],"expression":[83,123,181],"when":[84],"analyzed":[85],"in":[86,124,135,144,182,197],"two":[87],"cell":[89,126],"types":[90],"microarray":[92],"analysis.":[93],"Interestingly,":[94],"preferentially":[99],"expressed":[100],"on":[101],"primary":[102],"hepatocytes":[103],"within":[104],"normal":[105],"liver":[106],"pegylated":[108],"forms":[109],"IFN-alpha":[113,164],"induced":[114],"equivalent":[115],"2'5'":[116],"oligoadenylate":[117],"synthetase":[118],"(OAS)":[119],"MX1":[121],"type.":[127],"Pegylated":[128],"also":[130],"produced":[131],"significant":[133,179],"reduction":[134],"human":[136,198],"hepatitis":[137,140,183,196],"B":[138],"C":[141],"viral":[142,195],"load":[143],"vitro":[145],"reduced":[147],"cytopathic":[149],"effect":[150],"caused":[151],"fully":[154],"replicating":[155],"flavivirus,":[156],"West":[157],"Nile":[158],"virus.":[159],"In":[160],"conclusion,":[161],"despite":[169],"their":[170],"utilization":[171],"different":[173],"receptors.":[174],"This":[175],"fact,":[176],"combined":[177],"with":[178],"virus-infected":[184],"livers,":[185],"suggests":[186],"may":[189],"have":[190],"therapeutic":[191],"value":[192],"against":[193],"chronic":[194],"patients.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":36},{"year":2014,"cited_by_count":35},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":35}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}