{"id":"https://openalex.org/W2068879625","doi":"https://doi.org/10.1016/s0022-5347(05)68632-6","title":"FGF7 AND FGF2 ARE INCREASED IN BENIGN PROSTATIC HYPERPLASIA AND ARE ASSOCIATED WITH INCREASED PROLIFERATION","display_name":"FGF7 AND FGF2 ARE INCREASED IN BENIGN PROSTATIC HYPERPLASIA AND ARE ASSOCIATED WITH INCREASED PROLIFERATION","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2068879625","doi":"https://doi.org/10.1016/s0022-5347(05)68632-6","mag":"2068879625","pmid":"https://pubmed.ncbi.nlm.nih.gov/10411093"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(05)68632-6","doi":"https://doi.org/10.1016/s0022-5347(05)68632-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(05)68632-6","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108447089","display_name":"Fr\u00e9d\u00e9ric Ropiquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FREDERIC ROPIQUET","raw_affiliation_strings":["Department of Pathology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Texas 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085113307","display_name":"DIPAK GIRI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DIPAK GIRI","raw_affiliation_strings":["From the Departments of Pathology, Cell Biology and Urology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Cell Biology and Urology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088539818","display_name":"Dolores J. Lamb","orcid":"https://orcid.org/0000-0002-4389-5065","observed_orcids":["https://orcid.org/0000-0002-4389-5065"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DOLORES J. LAMB","raw_affiliation_strings":["From the Departments of Pathology, Cell Biology and Urology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Cell Biology and Urology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066263660","display_name":"Michael Ittmann","orcid":"https://orcid.org/0000-0003-4802-0978","observed_orcids":["https://orcid.org/0000-0003-4802-0978"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL ITTMANN","raw_affiliation_strings":["From the Departments of Pathology, Cell Biology and Urology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pathology, Cell Biology and Urology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":5.7628,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.96363636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"162","issue":"2","first_page":"595","last_page":"599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf7","display_name":"FGF7","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fibroblast-growth-factor","display_name":"fibroblast growth factor","score":0.8169999718666077},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/stromal-proliferation","display_name":"stromal cell proliferation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9580000042915344},{"id":"https://openalex.org/keywords/prostate-epithelial-cells","display_name":"prostate epithelial cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/prostatic-stromal-cells","display_name":"prostate stromal cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/growth-factor-overexpression","display_name":"growth factor overexpression","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.9053767919540405},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.7854082584381104},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7127465605735779},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5432333946228027},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5324091911315918},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4935084581375122},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4710918366909027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4500090777873993},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4180392622947693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35579240322113037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34914517402648926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22674384713172913},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.04177433252334595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051523","descriptor_name":"Fibroblast Growth Factor 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051526","descriptor_name":"Fibroblast Growth Factor 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-5347(05)68632-6","doi":"https://doi.org/10.1016/s0022-5347(05)68632-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(05)68632-6","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"doi:10.1097/00005392-199908000-00092","doi":"https://doi.org/10.1097/00005392-199908000-00092","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005392-199908000-00092","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Urology","raw_type":"journal-article"},{"id":"pmid:10411093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10411093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3936317034","display_name":"ROLE OF FIBROBLAST GROWTH FACTORS IN PROSTATE GROWTH","funder_award_id":"R01DK054170","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W132044012","https://openalex.org/W627471081","https://openalex.org/W1513451331","https://openalex.org/W1854803455","https://openalex.org/W1969997861","https://openalex.org/W1989866174","https://openalex.org/W1997783259","https://openalex.org/W2013608315","https://openalex.org/W2035982783","https://openalex.org/W2058712340","https://openalex.org/W2061623845","https://openalex.org/W2072303535","https://openalex.org/W2110669077","https://openalex.org/W2128635872","https://openalex.org/W2156166860","https://openalex.org/W2414527068","https://openalex.org/W2416107013","https://openalex.org/W2462851122"],"related_works":["https://openalex.org/W1995878068","https://openalex.org/W2017954814","https://openalex.org/W2364518463","https://openalex.org/W2061623845","https://openalex.org/W2271652619","https://openalex.org/W2013608315","https://openalex.org/W2015029645","https://openalex.org/W2086736850","https://openalex.org/W2026130525","https://openalex.org/W1974557172"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"if":[3,16],"overexpression":[4,20],"of":[5,26,39,42,60,75,87,97,104,151,161,201,210],"FGF7":[6,35,88,116,133,165,211],"and":[7,15,36,49,62,89,107,117,129,195,212],"FGF2":[8,37,90,118,187,202,213],"occurs":[9],"in":[10,84,121,124,141,146,167,179,185,193,219,225],"benign":[11,226],"prostatic":[12,51,105,227],"hyperplasia":[13],"(BPH)":[14],"so,":[17],"whether":[18],"such":[19],"is":[21,134,188],"correlated":[22],"with":[23,69,144,164,171,204],"increased":[24,205],"proliferation":[25,92,153,163,184,223],"epithelial":[27,61,106,139,162,183],"and/or":[28],"stromal":[29,63,108,191,206],"cells.":[30,109],"MATERIALS":[31],"AND":[32],"METHODS:":[33],"The":[34,83],"content":[38,166,203],"protein":[40,81],"extracts":[41],"normal":[43,46,127],"peripheral":[44,128],"zone,":[45],"transition":[47,130],"zone":[48,131],"hyperplastic":[50,122],"tissues":[52,78],"were":[53,93],"determined":[54],"by":[55,67,95,154],"enzyme-linked":[56],"immunoabsorption":[57],"assay.":[58],"Proliferation":[59],"cells":[64,140,192],"was":[65,197],"assessed":[66,94],"immunohistochemistry":[68,156],"anti-Ki67":[70],"antibodies":[71],"on":[72,91],"frozen":[73],"sections":[74],"the":[76,181,220],"same":[77],"used":[79],"for":[80,138,175,190],"extraction.":[82],"vitro":[85,147],"effects":[86],"addition":[96],"recombinant":[98],"growth":[99,177],"factor":[100,178],"to":[101,126],"primary":[102],"cultures":[103],"RESULTS:":[110],"We":[111],"have":[112],"found":[113],"that":[114],"both":[115],"are":[119],"overexpressed":[120],"prostate":[123],"comparison":[125],"tissue.":[132],"a":[135,158,172,198],"potent":[136],"mitogen":[137],"culture.":[142],"Consistent":[143],"these":[145],"effects,":[148],"quantitative":[149],"analysis":[150],"cellular":[152,222],"Ki67":[155],"revealed":[157],"strong":[159],"correlation":[160,200],"BPH":[168],"tissue,":[169],"consistent":[170],"key":[173],"role":[174,218],"this":[176],"driving":[180],"abnormal":[182,221],"BPH.":[186],"mitogenic":[189],"culture":[194],"there":[196],"weaker":[199],"proliferation.":[207],"CONCLUSION:":[208],"Overexpression":[209],"may":[214],"play":[215],"an":[216],"important":[217],"seen":[224],"hyperplasia.":[228]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}