{"id":"https://openalex.org/W2068844166","doi":"https://doi.org/10.1002/cmdc.201490031","title":"Back Cover: 3\u2010(2\u2010Oxoethylidene)indolin\u20102\u2010one Derivatives Activate Nrf2 and Inhibit NF\u2010\u03baB: Potential Candidates for Chemoprevention (ChemMedChem 8/2014)","display_name":"Back Cover: 3\u2010(2\u2010Oxoethylidene)indolin\u20102\u2010one Derivatives Activate Nrf2 and Inhibit NF\u2010\u03baB: Potential Candidates for Chemoprevention (ChemMedChem 8/2014)","publication_year":2014,"publication_date":"2014-07-28","ids":{"openalex":"https://openalex.org/W2068844166","doi":"https://doi.org/10.1002/cmdc.201490031","mag":"2068844166"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201490031","doi":"https://doi.org/10.1002/cmdc.201490031","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201490031","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"paratext","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081187699","display_name":"Amrita Abhay Nagle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Amrita A. Nagle","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076664348","display_name":"Shridhivya A. Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shridhivya A. Reddy","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051690404","display_name":"H\u00e9l\u00e8ne Charlotte Bertrand","orcid":"https://orcid.org/0000-0002-3841-022X","observed_orcids":["https://orcid.org/0000-0002-3841-022X"]},"institutions":[{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helene Bertrand","raw_affiliation_strings":["UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111422786","display_name":"Hisashi Tajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149737975","display_name":"Santen (Japan)","ror":"https://ror.org/032msy923","country_code":"JP","type":"company","lineage":["https://openalex.org/I149737975"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","JP"],"is_corresponding":false,"raw_author_name":"Hisashi Tajima","raw_affiliation_strings":["Santen Pharmaceutical Company Ltd., Ikoma, Nara (Japan)","UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santen Pharmaceutical Company Ltd., Ikoma, Nara (Japan)","institution_ids":["https://openalex.org/I149737975"]},{"raw_affiliation_string":"UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034207505","display_name":"Truong\u2010Minh Dang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Truong\u2010Minh Dang","raw_affiliation_strings":["Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8a Biomedical Grove, Singapore 138648 (Republic of Singapore)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8a Biomedical Grove, Singapore 138648 (Republic of Singapore)","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007338010","display_name":"Siew Cheng Wong","orcid":"https://orcid.org/0000-0003-3979-6096","observed_orcids":["https://orcid.org/0000-0003-3979-6096"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Siew\u2010Cheng Wong","raw_affiliation_strings":["Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8a Biomedical Grove, Singapore 138648 (Republic of Singapore)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8a Biomedical Grove, Singapore 138648 (Republic of Singapore)","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046024649","display_name":"John D. Hayes","orcid":"https://orcid.org/0000-0002-2927-5548","observed_orcids":["https://orcid.org/0000-0002-2927-5548"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John D. Hayes","raw_affiliation_strings":["Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY (UK)","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075893388","display_name":"Geoffrey Wells","orcid":"https://orcid.org/0000-0002-0253-911X","observed_orcids":["https://orcid.org/0000-0002-0253-911X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","SG"],"is_corresponding":true,"raw_author_name":"Geoffrey Wells","raw_affiliation_strings":["Eng-Hui Chew, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)===","Geoffrey Wells, UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)===","UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eng-Hui Chew, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)===","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Geoffrey Wells, UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)===","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"raw_affiliation_string":"UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068845562","display_name":"Eng\u2010Hui Chew","orcid":"https://orcid.org/0000-0002-2615-8987","observed_orcids":["https://orcid.org/0000-0002-2615-8987"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","SG"],"is_corresponding":true,"raw_author_name":"Eng\u2010Hui Chew","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)","Eng-Hui Chew, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)===","Geoffrey Wells, UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)==="],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Eng-Hui Chew, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore)===","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Geoffrey Wells, UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX (UK)===","institution_ids":["https://openalex.org/I4405283614","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5068845562","https://openalex.org/A5075893388"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405283614","https://openalex.org/I45129253"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"8","first_page":"1912","last_page":"1912"},"is_retracted":false,"is_paratext":true,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2-activation","display_name":"Nrf2 activation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.8790000081062317},{"id":"https://openalex.org/keywords/keap1-nrf2-pathway","display_name":"Nrf2/Keap1 pathway","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9340000152587891},{"id":"https://openalex.org/keywords/phase-ii-enzymes","display_name":"phase II enzymes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/inflammation-reduction","display_name":"inflammation reduction","score":0.800000011920929},{"id":"https://openalex.org/keywords/lead-compounds","display_name":"lead compounds","score":0.4580000042915344},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6804836988449097},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5835920572280884},{"id":"https://openalex.org/C2776529522","wikidata":"https://www.wikidata.org/wiki/Q18034700","display_name":"KEAP1","level":4,"score":0.540604829788208},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49190449714660645},{"id":"https://openalex.org/C2780428219","wikidata":"https://www.wikidata.org/wiki/Q16952335","display_name":"Cover (algebra)","level":2,"score":0.44253674149513245},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40919774770736694},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3982263505458832},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3950551152229309},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3476402759552002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3203921318054199},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18184322118759155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18103832006454468},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11325812339782715},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/cmdc.201490031","doi":"https://doi.org/10.1002/cmdc.201490031","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201490031","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7023603702","https://openalex.org/W2166017917","https://openalex.org/W7011724980","https://openalex.org/W1485963791","https://openalex.org/W2066241876","https://openalex.org/W2339451795","https://openalex.org/W3115992209","https://openalex.org/W2087669579","https://openalex.org/W2890019863","https://openalex.org/W2064512387"],"abstract_inverted_index":{"The":[0],"back":[1],"cover":[2],"picture":[3],"shows":[4],"lead":[5],"and":[6,13,30],"parent":[7],"analogues":[8],"of":[9,26],"3-(2-oxopropylidene)indolin-2-ones":[10],"targeting":[11],"Nrf2-Keap1":[12],"NF-\u03baB":[14],"signaling":[15],"pathways.":[16],"At":[17],"the":[18,46],"cellular":[19],"level,":[20],"these":[21],"compounds":[22],"induce":[23],"Nrf2-mediated":[24],"expression":[25],"phase":[27],"2":[28],"enzymes":[29],"suppress":[31],"NF-\u03baB-directed":[32],"inflammation,":[33],"which":[34],"makes":[35],"them":[36],"promising":[37],"development":[38],"candidates":[39],"for":[40],"chemoprevention.":[41],"For":[42],"more":[43],"details,":[44],"see":[45],"Full":[47],"Paper":[48],"by":[49],"Geoffrey":[50],"Wells,":[51],"Eng-Hui":[52],"Chew":[53],"et":[54],"al.":[55],"on":[56],"p.":[57],"1763":[58],"ff.":[59]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}