{"id":"https://openalex.org/W2068833950","doi":"https://doi.org/10.3390/md13020713","title":"Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius","display_name":"Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius","publication_year":2015,"publication_date":"2015-01-26","ids":{"openalex":"https://openalex.org/W2068833950","doi":"https://doi.org/10.3390/md13020713","mag":"2068833950","pmid":"https://pubmed.ncbi.nlm.nih.gov/25629386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4344597"},"language":"en","primary_location":{"id":"doi:10.3390/md13020713","doi":"https://doi.org/10.3390/md13020713","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/md13020713","pdf_url":"https://www.mdpi.com/1660-3397/13/2/713/pdf?version=1424783660","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-3397/13/2/713/pdf?version=1424783660","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045837693","display_name":"Daniel Rodrigues","orcid":"https://orcid.org/0000-0002-0162-8065","observed_orcids":["https://orcid.org/0000-0002-0162-8065"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I169427155","display_name":"Universidade de Leiria e Oeste","ror":"https://ror.org/010dvvh94","country_code":"PT","type":"education","lineage":["https://openalex.org/I169427155"]},{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR","PT"],"is_corresponding":false,"raw_author_name":"Daniel Rodrigues","raw_affiliation_strings":["Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal","Nice Institute of Chemistry-PCRE, UMR 7272 CNRS, University de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal","institution_ids":["https://openalex.org/I169427155"]},{"raw_affiliation_string":"Nice Institute of Chemistry-PCRE, UMR 7272 CNRS, University de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086528","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024726073","display_name":"Celso Alves","orcid":"https://orcid.org/0000-0003-1581-2127","observed_orcids":["https://orcid.org/0000-0003-1581-2127"]},"institutions":[{"id":"https://openalex.org/I169427155","display_name":"Universidade de Leiria e Oeste","ror":"https://ror.org/010dvvh94","country_code":"PT","type":"education","lineage":["https://openalex.org/I169427155"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Celso Alves","raw_affiliation_strings":["Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal","institution_ids":["https://openalex.org/I169427155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031335375","display_name":"Andr\u00e9 Horta","orcid":"https://orcid.org/0000-0003-2178-1849","observed_orcids":["https://orcid.org/0000-0003-2178-1849"]},"institutions":[{"id":"https://openalex.org/I169427155","display_name":"Universidade de Leiria e Oeste","ror":"https://ror.org/010dvvh94","country_code":"PT","type":"education","lineage":["https://openalex.org/I169427155"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Horta","raw_affiliation_strings":["Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal","institution_ids":["https://openalex.org/I169427155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076993757","display_name":"Susete Pint\u00e9us","orcid":"https://orcid.org/0000-0002-3290-3111","observed_orcids":["https://orcid.org/0000-0002-3290-3111"]},"institutions":[{"id":"https://openalex.org/I169427155","display_name":"Universidade de Leiria e Oeste","ror":"https://ror.org/010dvvh94","country_code":"PT","type":"education","lineage":["https://openalex.org/I169427155"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susete Pinteus","raw_affiliation_strings":["Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-3290-3111","affiliations":[{"raw_affiliation_string":"Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal","institution_ids":["https://openalex.org/I169427155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007940313","display_name":"Joana Silva","orcid":"https://orcid.org/0000-0003-1224-1699","observed_orcids":["https://orcid.org/0000-0003-1224-1699"]},"institutions":[{"id":"https://openalex.org/I169427155","display_name":"Universidade de Leiria e Oeste","ror":"https://ror.org/010dvvh94","country_code":"PT","type":"education","lineage":["https://openalex.org/I169427155"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Silva","raw_affiliation_strings":["Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal","institution_ids":["https://openalex.org/I169427155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063583658","display_name":"G\u00e9rald Culioli","orcid":"https://orcid.org/0000-0001-5760-6394","observed_orcids":["https://orcid.org/0000-0001-5760-6394"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I143002897","display_name":"Universit\u00e9 de Toulon","ror":"https://ror.org/02m9kbe37","country_code":"FR","type":"education","lineage":["https://openalex.org/I143002897"]},{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]},{"id":"https://openalex.org/I4399598469","display_name":"Mat\u00e9riaux Polym\u00e8res Interfaces - Environnement Marin","ror":"https://ror.org/03jqp8097","country_code":"FR","type":"facility","lineage":["https://openalex.org/I143002897","https://openalex.org/I4399598469"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G\u00e9rald Culioli","raw_affiliation_strings":["MAPIEM, EA 4323, Universit\u00e9 de Toulon, 83957 La Garde, France","Nice Institute of Chemistry-PCRE, UMR 7272 CNRS, University de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAPIEM, EA 4323, Universit\u00e9 de Toulon, 83957 La Garde, France","institution_ids":["https://openalex.org/I143002897","https://openalex.org/I4399598469"]},{"raw_affiliation_string":"Nice Institute of Chemistry-PCRE, UMR 7272 CNRS, University de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086528","https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103635174","display_name":"OP Thomas","orcid":"https://orcid.org/0000-0002-5708-1409","observed_orcids":["https://orcid.org/0000-0002-5708-1409"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]},{"id":"https://openalex.org/I4210142374","display_name":"Institut M\u00e9diterran\u00e9en de Biodiversit\u00e9 et d'Ecologie Marine et Continentale","ror":"https://ror.org/0409c3995","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I198415970","https://openalex.org/I21491767","https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210107625","https://openalex.org/I4210131494","https://openalex.org/I4210142374","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Thomas","raw_affiliation_strings":["Mediterranean Institute of Biodiversity and Ecology, Marine and Continental, Rue de la Batterie des Lions, 13007 Marseille, France","Nice Institute of Chemistry-PCRE, UMR 7272 CNRS, University de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mediterranean Institute of Biodiversity and Ecology, Marine and Continental, Rue de la Batterie des Lions, 13007 Marseille, France","institution_ids":["https://openalex.org/I4210142374"]},{"raw_affiliation_string":"Nice Institute of Chemistry-PCRE, UMR 7272 CNRS, University de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210086528","https://openalex.org/I4387154757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006401610","display_name":"Rui Pedrosa","orcid":"https://orcid.org/0000-0003-0970-0575","observed_orcids":["https://orcid.org/0000-0003-0970-0575"]},"institutions":[{"id":"https://openalex.org/I169427155","display_name":"Universidade de Leiria e Oeste","ror":"https://ror.org/010dvvh94","country_code":"PT","type":"education","lineage":["https://openalex.org/I169427155"]},{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Rui Pedrosa","raw_affiliation_strings":["Centre of Pharmacology and Chemical Biopathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal","Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Pharmacology and Chemical Biopathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal","institution_ids":["https://openalex.org/I169427155"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5006401610"],"corresponding_institution_ids":["https://openalex.org/I169427155","https://openalex.org/I182534213"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":3.3903,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.92746911,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"713","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.33399999141693115,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.24269999563694,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphaerococcus-coronopifolius","display_name":"Sphaerococcus coronopifolius","score":0.9950000047683716},{"id":"https://openalex.org/keywords/red-algae","display_name":"red algae","score":0.9490000009536743},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.843999981880188},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9610000252723694},{"id":"https://openalex.org/keywords/marine-natural-products","display_name":"marine natural products","score":0.7110000252723694},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8710085153579712},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7925707101821899},{"id":"https://openalex.org/C2776710815","wikidata":"https://www.wikidata.org/wiki/Q59447","display_name":"Diterpene","level":2,"score":0.7744211554527283},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7623418569564819},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7433197498321533},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5510646104812622},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5169153213500977},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.502626895904541},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4862626791000366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47850146889686584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36363497376441956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2836911082267761},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23998311161994934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10513344407081604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006842","descriptor_name":"Hydrocarbons, Brominated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006842","descriptor_name":"Hydrocarbons, Brominated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/md13020713","doi":"https://doi.org/10.3390/md13020713","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/md13020713","pdf_url":"https://www.mdpi.com/1660-3397/13/2/713/pdf?version=1424783660","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4344597","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4344597","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmid:25629386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25629386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04565050v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04565050","pdf_url":"https://hal.science/hal-04565050/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine drugs, 2015, 13 (2), pp.713-726. ⟨10.3390/md13020713⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.697.2599","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.697.2599","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1660-3397/13/2/713/pdf/","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2a63da3c677a45a38d209c5d0c989d85","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2a63da3c677a45a38d209c5d0c989d85","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 13, Iss 2, Pp 713-726 (2015)","raw_type":"article"},{"id":"pmh:oai:iconline.ulo.pt:10400.8/6084","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.8/6084","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3390/md13020713","doi":"https://doi.org/10.3390/md13020713","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/md13020713","pdf_url":"https://www.mdpi.com/1660-3397/13/2/713/pdf?version=1424783660","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3020557793","display_name":"Sustainable production of biologically active molecules of marine based origin","funder_award_id":"265896","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068833950.pdf","grobid_xml":"https://content.openalex.org/works/W2068833950.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W76136945","https://openalex.org/W108823702","https://openalex.org/W1968005134","https://openalex.org/W1968882230","https://openalex.org/W1977044600","https://openalex.org/W1988907937","https://openalex.org/W1990847415","https://openalex.org/W1992126003","https://openalex.org/W1997280577","https://openalex.org/W2000371079","https://openalex.org/W2003622793","https://openalex.org/W2007776162","https://openalex.org/W2013440223","https://openalex.org/W2015907706","https://openalex.org/W2017462074","https://openalex.org/W2017945777","https://openalex.org/W2024383044","https://openalex.org/W2026950145","https://openalex.org/W2039697464","https://openalex.org/W2039809594","https://openalex.org/W2043197059","https://openalex.org/W2059673734","https://openalex.org/W2065295291","https://openalex.org/W2066071623","https://openalex.org/W2072892575","https://openalex.org/W2073768231","https://openalex.org/W2080275025","https://openalex.org/W2080981798","https://openalex.org/W2081079409","https://openalex.org/W2085076366","https://openalex.org/W2086989680","https://openalex.org/W2089865589","https://openalex.org/W2104421247","https://openalex.org/W2105180276","https://openalex.org/W2111573377","https://openalex.org/W2116877729","https://openalex.org/W2138732673","https://openalex.org/W2143675543","https://openalex.org/W2168389563","https://openalex.org/W2169637929","https://openalex.org/W4239912220","https://openalex.org/W6992057981"],"related_works":["https://openalex.org/W7098971339","https://openalex.org/W2909847715","https://openalex.org/W2080275025","https://openalex.org/W2085076366","https://openalex.org/W1968005134","https://openalex.org/W2024383044","https://openalex.org/W2997043855","https://openalex.org/W2950082216","https://openalex.org/W2059673734","https://openalex.org/W1899010461"],"abstract_inverted_index":{"Cancer":[0],"and":[1,12,63,72,86,104,132,148,174,182],"infectious":[2],"diseases":[3],"continue":[4],"to":[5,23,37,81],"be":[6],"a":[7,25,76],"major":[8],"public":[9],"health":[10],"problem,":[11],"new":[13,77,162],"drugs":[14],"are":[15,20],"necessary.":[16],"As":[17],"marine":[18],"organisms":[19],"well":[21],"known":[22,94],"provide":[24],"wide":[26],"range":[27],"of":[28,33,41,45,54,112,168],"original":[29],"compounds,":[30],"the":[31,39,42,46,82,138,151],"aim":[32],"this":[34],"study":[35],"was":[36,57,100,120],"investigate":[38],"bioactivity":[40],"main":[43],"constituents":[44],"cosmopolitan":[47],"red":[48],"alga,":[49],"Sphaerococcus":[50],"coronopifolius.":[51],"The":[52,161],"structure":[53],"several":[55],"bromoditerpenes":[56,96],"determined":[58],"by":[59,102],"extensive":[60],"spectroscopic":[61],"analysis":[62],"comparison":[64],"with":[65,91],"literature":[66],"data.":[67],"Five":[68],"molecules":[69],"were":[70],"isolated":[71],"characterized":[73],"which":[74],"include":[75],"brominated":[78],"diterpene":[79],"belonging":[80],"rare":[83],"dactylomelane":[84],"family":[85],"named":[87],"sphaerodactylomelol":[88,164],"(1),":[89,165],"along":[90],"four":[92,123],"already":[93],"sphaerane":[95],"(2-5).":[97],"Antitumor":[98],"activity":[99,119,141,154,185],"assessed":[101],"cytotoxicity":[103,175],"anti-proliferative":[105,153],"assays":[106],"on":[107,155,179],"an":[108],"in":[109],"vitro":[110],"model":[111],"human":[113],"hepatocellular":[114],"carcinoma":[115],"(HepG-2":[116],"cells).":[117],"Antimicrobial":[118],"evaluated":[121],"against":[122,142,186],"pathogenic":[124],"microorganisms:":[125],"Escherichia":[126],"coli,":[127],"Pseudomonas":[128],"aeruginosa,":[129],"Staphylococcus":[130],"aureus":[131,144,188],"Candida":[133],"albicans.":[134],"Compound":[135],"4":[136],"exhibited":[137],"highest":[139,152],"antimicrobial":[140,184],"S.":[143,187],"(IC50":[145,158,171,176,189],"6.35":[146],"\u00b5M)":[147,173,178],"compound":[149],"5":[150],"HepG-2":[156,180],"cells":[157,181],"42.9":[159],"\u00b5M).":[160,191],"diterpene,":[163],"induced":[166],"inhibition":[167],"cell":[169],"proliferation":[170],"280":[172],"720":[177],"showed":[183],"96.3":[190]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}