{"id":"https://openalex.org/W20687422","doi":null,"title":"Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis.","display_name":"Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W20687422","mag":"20687422","pmid":"https://pubmed.ncbi.nlm.nih.gov/7927488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414820"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1414820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414820","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087150619","display_name":"Keisuke Masuyama","orcid":"https://orcid.org/0000-0001-7104-835X","observed_orcids":["https://orcid.org/0000-0001-7104-835X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Masuyama","raw_affiliation_strings":["Department of Allergy & Clinical Immunology, National Heart & Lung Institute, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy & Clinical Immunology, National Heart & Lung Institute, London, U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016205497","display_name":"Mikila R. Jacobson","orcid":"https://orcid.org/0000-0002-2921-6169","observed_orcids":["https://orcid.org/0000-0002-2921-6169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Jacobson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000562434","display_name":"S. Rak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101696763","display_name":"Q. Meng","orcid":"https://orcid.org/0009-0009-8443-3367","observed_orcids":["https://orcid.org/0009-0009-8443-3367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082156006","display_name":"Robert M. Sudderick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Sudderick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113998589","display_name":"A. Barry Kay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Kay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021246152","display_name":"Olle Lowhagen","orcid":"https://orcid.org/0000-0002-0447-1980","observed_orcids":["https://orcid.org/0000-0002-0447-1980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Lowhagen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027127170","display_name":"Qutayba A. Hamid","orcid":"https://orcid.org/0000-0002-1107-190X","observed_orcids":["https://orcid.org/0000-0002-1107-190X","https://orcid.org/0000-0003-3341-2813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q Hamid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043192106","display_name":"Stephen R. Durham","orcid":"https://orcid.org/0000-0001-5264-6207","observed_orcids":["https://orcid.org/0000-0001-5264-6207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S R Durham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.648,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.89548213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"82","issue":"2","first_page":"192","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluticasone-propionate","display_name":"fluticasone propionate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.984000027179718},{"id":"https://openalex.org/keywords/grass-pollen-allergy","display_name":"grass pollen allergy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9259999990463257},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9950000047683716},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.9670000076293945},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nasal-mucosa","display_name":"nasal mucosa","score":0.7179999947547913},{"id":"https://openalex.org/keywords/allergen-challenge","display_name":"allergen challenge","score":0.7080000042915344},{"id":"https://openalex.org/keywords/nasal-biopsy","display_name":"nasal biopsy","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2779028295","wikidata":"https://www.wikidata.org/wiki/Q8564098","display_name":"Fluticasone propionate","level":3,"score":0.688441812992096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5785872340202332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5668405890464783},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.5629127025604248},{"id":"https://openalex.org/C59377437","wikidata":"https://www.wikidata.org/wiki/Q515471","display_name":"Mucous membrane of nose","level":2,"score":0.5507305264472961},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.548300564289093},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.5350445508956909},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.507323682308197},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46025359630584717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45101502537727356},{"id":"https://openalex.org/C2781212218","wikidata":"https://www.wikidata.org/wiki/Q1002165","display_name":"Fluticasone","level":3,"score":0.44156837463378906},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.4207506775856018},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4178123474121094},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.41366636753082275},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3728494644165039},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.12950429320335388}],"mesh":[{"descriptor_ui":"D000068298","descriptor_name":"Fluticasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011058","descriptor_name":"Pollen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1414820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:7927488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7927488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Clinical Trial"},{"id":"mag:20687422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7927488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1414820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1414820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W149204222","https://openalex.org/W218521522","https://openalex.org/W1497022815","https://openalex.org/W1500174031","https://openalex.org/W1533977973","https://openalex.org/W1801833206","https://openalex.org/W1831711338","https://openalex.org/W1942668068","https://openalex.org/W1969132883","https://openalex.org/W1983728146","https://openalex.org/W1989142540","https://openalex.org/W2014106012","https://openalex.org/W2020977425","https://openalex.org/W2021794070","https://openalex.org/W2030376048","https://openalex.org/W2050848763","https://openalex.org/W2055705628","https://openalex.org/W2063482779","https://openalex.org/W2065508020","https://openalex.org/W2080331925","https://openalex.org/W2080502516","https://openalex.org/W2099109162","https://openalex.org/W2099865106","https://openalex.org/W2109347130","https://openalex.org/W2120012263","https://openalex.org/W2144659614","https://openalex.org/W2151900684","https://openalex.org/W2160572043","https://openalex.org/W2337026407","https://openalex.org/W2405698336","https://openalex.org/W2410543686","https://openalex.org/W2417291931","https://openalex.org/W2418540434","https://openalex.org/W4242711348"],"related_works":["https://openalex.org/W2088988612","https://openalex.org/W2081992291","https://openalex.org/W2012829998","https://openalex.org/W1969963951","https://openalex.org/W2114792473","https://openalex.org/W1966019053","https://openalex.org/W2124260132","https://openalex.org/W1974592243","https://openalex.org/W2012480358","https://openalex.org/W2050807435"],"abstract_inverted_index":{"Allergen-induced":[0],"late":[1,34,130,162,213],"nasal":[2,74,89,122,214],"responses":[3,35,215],"are":[4],"associated":[5,137,218],"with":[6,81,124,138,206],"recruitment":[7],"and":[8,13,15,68,102,175,189,212,216,221],"activation":[9],"of":[10,49,128,160,232],"T":[11,173],"lymphocytes":[12,174],"eosinophils":[14,191],"preferential":[16],"mRNA":[17,40,94,149,235],"expression":[18,95],"for":[19,41,96,150,157,236],"T-helper":[20],"type":[21],"2":[22],"(Th2)":[23],"cytokines.":[24,43],"We":[25],"tested":[26],"the":[27,110,129,143,161,183,217],"hypothesis":[28],"that":[29,203],"topical":[30,50,207],"corticosteroids":[31],"may":[32,228],"inhibit":[33],"by":[36,167],"inhibiting":[37],"cells":[38,147,188,233],"expressing":[39,148,234],"Th2":[42],"A":[44,177],"randomized":[45],"double-blind":[46],"placebo-controlled":[47],"trial":[48],"corticosteroid":[51,117,208],"(fluticasone":[52],"propionate)":[53],"was":[54,107,136,164,180],"performed":[55],"in":[56,109,113,142,146,169,185,190,225],"48":[57],"adult":[58],"grass":[59],"pollen-sensitive":[60],"patients.":[61],"Nasal":[62],"biopsies":[63],"were":[64],"taken":[65],"at":[66,223],"baseline":[67],"repeated":[69],"24":[70],"hr":[71],"after":[72,192],"local":[73],"allergen":[75,133],"provocation":[76],"following":[77,132],"6":[78],"weeks":[79],"treatment":[80,118,193,205],"either":[82],"fluticasone":[83],"propionate":[84],"200":[85],"micrograms":[86],"or":[87],"placebo":[88],"spray":[90],"twice":[91],"daily.":[92],"Baseline":[93],"interleukin-4":[97],"(IL-4)":[98],"(P":[99,104,152],"=":[100,105,153,195],"0.01)":[101],"IL-5":[103],"0.002)":[106,154],"higher":[108],"patients":[111],"than":[112],"normal":[114],"controls.":[115],"Topical":[116],"significantly":[119],"inhibited":[120],"immediate":[121],"symptoms,":[123],"almost":[125],"complete":[126],"inhibition":[127,231],"response":[131,163],"challenge.":[134],"This":[135],"a":[139],"marked":[140],"decrease":[141],"allergen-induced":[144,210],"increases":[145],"IL-4":[151,186],"but":[155],"not":[156],"IL-5.":[158],"Inhibition":[159],"also":[165],"accompanied":[166],"decreases":[168,184],"CD25+":[170],"cells,":[171],"presumed":[172],"eosinophils.":[176],"significant":[178],"correlation":[179],"observed":[181],"between":[182],"mRNA+":[187],"(r":[194],"0.46,":[196],"P":[197],"<":[198],"0.05).":[199],"These":[200],"results":[201],"suggest":[202],"prolonged":[204],"inhibits":[209],"early":[211],"tissue":[219],"eosinophilia,":[220],"that,":[222],"least":[224],"part,":[226],"this":[227],"result":[229],"from":[230],"IL-4.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
