{"id":"https://openalex.org/W2068664302","doi":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","title":"Sex differences in survival and mitochondrial bioenergetics during aging inDrosophila","display_name":"Sex differences in survival and mitochondrial bioenergetics during aging inDrosophila","publication_year":2007,"publication_date":"2007-07-20","ids":{"openalex":"https://openalex.org/W2068664302","doi":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","mag":"2068664302","pmid":"https://pubmed.ncbi.nlm.nih.gov/17725690"},"language":"en","primary_location":{"id":"doi:10.1111/j.1474-9726.2007.00331.x","doi":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2007.00331.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2007.00331.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008384445","display_name":"John William O. Ballard","orcid":"https://orcid.org/0000-0002-2358-6003","observed_orcids":["https://orcid.org/0000-0002-2358-6003"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"J. William O. Ballard","raw_affiliation_strings":["Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. w.ballard@unsw.edu.au","Radiation Oncology and","Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. w.ballard@unsw.edu.au","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Radiation Oncology and","institution_ids":[]},{"raw_affiliation_string":"Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia Departments of","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084400853","display_name":"Richard G. Melvin","orcid":"https://orcid.org/0000-0001-6428-6763","observed_orcids":["https://orcid.org/0000-0001-6428-6763"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard G. Melvin","raw_affiliation_strings":["Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia Departments of","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035510410","display_name":"Joseph T. Miller","orcid":"https://orcid.org/0000-0002-5788-9010","observed_orcids":["https://orcid.org/0000-0002-5788-9010"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph T. Miller","raw_affiliation_strings":["Biological Science, University of Iowa, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Science, University of Iowa, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051499001","display_name":"Subhash D. Katewa","orcid":"https://orcid.org/0000-0002-8440-1041","observed_orcids":["https://orcid.org/0000-0002-8440-1041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subhash D. Katewa","raw_affiliation_strings":["Radiation Oncology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008384445"],"corresponding_institution_ids":["https://openalex.org/I31746571"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.6896,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.66071429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"699","last_page":"708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8059999942779541},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.7059999704360962},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.7739999890327454},{"id":"https://openalex.org/keywords/drosophila-simulans","display_name":"Drosophila simulans","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7689999938011169},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7350000143051147},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.36500000953674316},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.949596643447876},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.8154709935188293},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.705691933631897},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5993566513061523},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.5822690725326538},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4158933162689209},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.37740933895111084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19263103604316711}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1474-9726.2007.00331.x","doi":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2007.00331.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmid:17725690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17725690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1474-9726.2007.00331.x","doi":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2007.00331.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2007.00331.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2483798824","display_name":null,"funder_award_id":"GM067862-01","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3404670308","display_name":"Nuclear-Mitochondrial Fitness Interactions in Drosophila","funder_award_id":"R01GM067862","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3539196616","display_name":"Mitochondrial Metabolism and Oxidative Efficiency in Drosophila","funder_award_id":"0444766","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6205706282","display_name":null,"funder_award_id":"DEB-0444766","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068664302.pdf","grobid_xml":"https://content.openalex.org/works/W2068664302.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W982953202","https://openalex.org/W1532383463","https://openalex.org/W1585796965","https://openalex.org/W1791864903","https://openalex.org/W1811419151","https://openalex.org/W1832024365","https://openalex.org/W1838085410","https://openalex.org/W1925799544","https://openalex.org/W1941119652","https://openalex.org/W1953801165","https://openalex.org/W1956327946","https://openalex.org/W1967540729","https://openalex.org/W1978390763","https://openalex.org/W1979048203","https://openalex.org/W1980654229","https://openalex.org/W1986877101","https://openalex.org/W1987981231","https://openalex.org/W1994853291","https://openalex.org/W1996324277","https://openalex.org/W1996440821","https://openalex.org/W1997408640","https://openalex.org/W1999312292","https://openalex.org/W2002973721","https://openalex.org/W2005011332","https://openalex.org/W2005787251","https://openalex.org/W2006132005","https://openalex.org/W2011745910","https://openalex.org/W2014569635","https://openalex.org/W2015110890","https://openalex.org/W2020122988","https://openalex.org/W2022369816","https://openalex.org/W2025152430","https://openalex.org/W2026867422","https://openalex.org/W2027950004","https://openalex.org/W2030568701","https://openalex.org/W2033886808","https://openalex.org/W2034103943","https://openalex.org/W2038345750","https://openalex.org/W2038473565","https://openalex.org/W2042191084","https://openalex.org/W2042928173","https://openalex.org/W2045838525","https://openalex.org/W2047336812","https://openalex.org/W2047683380","https://openalex.org/W2059598549","https://openalex.org/W2062205187","https://openalex.org/W2066852258","https://openalex.org/W2068076985","https://openalex.org/W2068115330","https://openalex.org/W2071012903","https://openalex.org/W2071250433","https://openalex.org/W2073349608","https://openalex.org/W2073455917","https://openalex.org/W2075404262","https://openalex.org/W2081969319","https://openalex.org/W2084249132","https://openalex.org/W2090771803","https://openalex.org/W2093384368","https://openalex.org/W2102350328","https://openalex.org/W2106441775","https://openalex.org/W2106621020","https://openalex.org/W2110728128","https://openalex.org/W2116398302","https://openalex.org/W2119187109","https://openalex.org/W2120666084","https://openalex.org/W2127262263","https://openalex.org/W2131207288","https://openalex.org/W2135201448","https://openalex.org/W2143265389","https://openalex.org/W2156579830","https://openalex.org/W2160924696","https://openalex.org/W2167650971","https://openalex.org/W2176491655","https://openalex.org/W2282882494","https://openalex.org/W2315512556","https://openalex.org/W4211228471","https://openalex.org/W4388362634"],"related_works":["https://openalex.org/W2042928173","https://openalex.org/W2068076985","https://openalex.org/W2110728128","https://openalex.org/W2131938168","https://openalex.org/W2020431992","https://openalex.org/W2165500409","https://openalex.org/W4402849763","https://openalex.org/W3014612575","https://openalex.org/W109953986","https://openalex.org/W2131703306"],"abstract_inverted_index":{"The":[0],"goal":[1],"of":[2,10,13,23,41,49,70,92],"this":[3],"study":[4],"is":[5],"to":[6,35,56,63],"test":[7],"the":[8,18,115],"role":[9],"mitochondria":[11,84],"and":[12,25,45,75,82,99,120,125],"mitochondrial":[14,121],"metabolism":[15,122],"in":[16,123,126],"determining":[17],"processes":[19],"that":[20,30,117],"influence":[21,118],"aging":[22,119],"female":[24],"male":[26],"Drosophila.":[27],"We":[28],"observe":[29],"Drosophila":[31,81,124],"simulans":[32],"females":[33,61,87],"tended":[34],"have":[36,67,100],"shorter":[37],"lifespan,":[38],"higher":[39,76,90],"levels":[40,48],"hydrogen":[42],"peroxide":[43],"production":[44,74],"significantly":[46],"lower":[47,68],"catalase":[50],"but":[51,128],"not":[52],"superoxide":[53],"dismutase":[54],"compared":[55],"males.":[57,107],"In":[58,79],"contrast,":[59],"mammalian":[60],"tend":[62],"be":[64],"longer":[65],"lived,":[66],"rates":[69],"reactive":[71],"oxygen":[72,93],"species":[73],"antioxidant":[77],"activity.":[78],"both":[80],"mammals,":[83],"extracted":[85],"from":[86],"consume":[88],"a":[89,101],"quantity":[91],"when":[94],"provided":[95],"with":[96],"adenosine":[97],"diphosphate":[98],"greater":[102],"mtDNA":[103],"copy":[104],"number":[105],"than":[106],"Combined,":[108],"these":[109],"data":[110],"illustrate":[111],"important":[112],"similarities":[113],"between":[114],"parameters":[116],"mammals":[127],"also":[129],"show":[130],"surprising":[131],"differences.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}