{"id":"https://openalex.org/W2068633952","doi":"https://doi.org/10.1088/0957-4484/24/12/125101","title":"The effect of cryoprotection on the use of PLGA encapsulated iron oxide nanoparticles for magnetic cell labeling","display_name":"The effect of cryoprotection on the use of PLGA encapsulated iron oxide nanoparticles for magnetic cell labeling","publication_year":2013,"publication_date":"2013-03-04","ids":{"openalex":"https://openalex.org/W2068633952","doi":"https://doi.org/10.1088/0957-4484/24/12/125101","mag":"2068633952","pmid":"https://pubmed.ncbi.nlm.nih.gov/23459030","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5026304"},"language":"en","primary_location":{"id":"doi:10.1088/0957-4484/24/12/125101","doi":"https://doi.org/10.1088/0957-4484/24/12/125101","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0957-4484/24/12/125101","pdf_url":"https://iopscience.iop.org/article/10.1088/0957-4484/24/12/125101/pdf","source":{"id":"https://openalex.org/S206811868","display_name":"Nanotechnology","issn_l":"0957-4484","issn":["0957-4484","1361-6528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iopscience.iop.org/article/10.1088/0957-4484/24/12/125101/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101987639","display_name":"Kevin Tang","orcid":"https://orcid.org/0000-0001-8963-1930","observed_orcids":["https://orcid.org/0000-0001-8963-1930"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin S Tang","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047973100","display_name":"Sara M. Hashmi","orcid":"https://orcid.org/0000-0002-2298-4392","observed_orcids":["https://orcid.org/0000-0002-2298-4392"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara M Hashmi","raw_affiliation_strings":["Department of Chemical & Environmental Engineering, Yale University, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Environmental Engineering, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049750913","display_name":"Erik M. Shapiro","orcid":"https://orcid.org/0000-0002-0901-5781","observed_orcids":["https://orcid.org/0000-0002-0901-5781"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erik M Shapiro","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA","Molecular and Cellular MRI Laboratory, Magnetic Resonance Research Center, Department of Diagnostic Radiology, 300 Cedar Street, Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Molecular and Cellular MRI Laboratory, Magnetic Resonance Research Center, Department of Diagnostic Radiology, 300 Cedar Street, Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049750913"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3325,"currency":"USD","value_usd":3325},"apc_paid":null,"fwci":1.728,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.83019948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"12","first_page":"125101","last_page":"125101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10922","display_name":"Magnetic Properties and Synthesis of Ferrites","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryoprotection","display_name":"cryoprotection","score":0.925000011920929},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.9610000252723694},{"id":"https://openalex.org/keywords/iron-oxide-nanoparticles","display_name":"iron oxide nanoparticles","score":0.9789999723434448},{"id":"https://openalex.org/keywords/magnetic-cell-labeling","display_name":"magnetic cell labeling","score":0.9660000205039978},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.7879999876022339},{"id":"https://openalex.org/keywords/d-glucose","display_name":"D-glucose","score":0.8840000033378601},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":1.0},{"id":"https://openalex.org/keywords/nanoparticle-aggregation","display_name":"nanoparticle aggregation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/monodispersity","display_name":"monodispersity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cell-tracking","display_name":"cell tracking","score":0.5979999899864197},{"id":"https://openalex.org/keywords/superparamagnetic-iron-oxide-nanoparticles","display_name":"superparamagnetic iron oxide nanoparticles","score":0.7839999794960022},{"id":"https://openalex.org/keywords/magnetic-iron-oxide-nanoparticles","display_name":"magnetic iron oxide nanoparticles","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.7220324873924255},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.7098594903945923},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7046229839324951},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.6950812339782715},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6616662740707397},{"id":"https://openalex.org/C2777697756","wikidata":"https://www.wikidata.org/wiki/Q721849","display_name":"Iron oxide","level":2,"score":0.5985257625579834},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.525924563407898},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.49968957901000977},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.440265953540802},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4113512635231018},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.08974552154541016},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003451","descriptor_name":"Cryoprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003451","descriptor_name":"Cryoprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013818","descriptor_name":"Thermogravimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053769","descriptor_name":"Nanocapsules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058185","descriptor_name":"Magnetite Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1088/0957-4484/24/12/125101","doi":"https://doi.org/10.1088/0957-4484/24/12/125101","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0957-4484/24/12/125101","pdf_url":"https://iopscience.iop.org/article/10.1088/0957-4484/24/12/125101/pdf","source":{"id":"https://openalex.org/S206811868","display_name":"Nanotechnology","issn_l":"0957-4484","issn":["0957-4484","1361-6528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotechnology","raw_type":"journal-article"},{"id":"pmid:23459030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23459030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5026304","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5026304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanotechnology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1088/0957-4484/24/12/125101","doi":"https://doi.org/10.1088/0957-4484/24/12/125101","is_oa":true,"landing_page_url":"https://doi.org/10.1088/0957-4484/24/12/125101","pdf_url":"https://iopscience.iop.org/article/10.1088/0957-4484/24/12/125101/pdf","source":{"id":"https://openalex.org/S206811868","display_name":"Nanotechnology","issn_l":"0957-4484","issn":["0957-4484","1361-6528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3877436166","display_name":"Magnetic Resonance Imaging of Neurogenesis","funder_award_id":"R21NS065297","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4763508761","display_name":"MRI-based immune cell tracking in Alzheimer?s disease","funder_award_id":"R21AG041266","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5605704244","display_name":"Single cell MRI of directed cell migration to stroke","funder_award_id":"DP2OD004362","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068633952.pdf","grobid_xml":"https://content.openalex.org/works/W2068633952.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W5531942","https://openalex.org/W1967454217","https://openalex.org/W1972621208","https://openalex.org/W1974321392","https://openalex.org/W2025401801","https://openalex.org/W2031178652","https://openalex.org/W2049643142","https://openalex.org/W2058227083","https://openalex.org/W2065982455","https://openalex.org/W2076166680","https://openalex.org/W2082369211","https://openalex.org/W2091267452","https://openalex.org/W2093746762","https://openalex.org/W2096546754","https://openalex.org/W2118969052","https://openalex.org/W2120826143","https://openalex.org/W2144611965","https://openalex.org/W2254092841","https://openalex.org/W2335040656"],"related_works":["https://openalex.org/W2025401801","https://openalex.org/W7112486637","https://openalex.org/W2162295176","https://openalex.org/W2359190230","https://openalex.org/W1509144955","https://openalex.org/W4318826660","https://openalex.org/W2044533195","https://openalex.org/W1996184101","https://openalex.org/W2316749632","https://openalex.org/W6961022494"],"abstract_inverted_index":{"Magnetic":[0,165],"PLGA":[1,62,97,125],"nanoparticles":[2,126,162],"are":[3,25],"a":[4,87],"significant":[5],"advancement":[6],"in":[7,91,121],"the":[8,16,41,75,92,158],"quest":[9],"to":[10,15,72,81,102,144,160],"translate":[11],"MRI-based":[12],"cell":[13,166,185,210],"tracking":[14],"clinic.":[17],"The":[18],"benefits":[19],"of":[20,23,31,44,56,70,94,116,132],"these":[21],"types":[22],"particles":[24,55,107],"that":[26,151,193,202],"they":[27],"encapsulate":[28],"large":[29],"amounts":[30],"iron":[32,47,57],"oxide":[33,48],"nanocrystals":[34],"within":[35],"an":[36,199],"FDA-approved":[37],"polymer":[38],"matrix,":[39],"combining":[40],"best":[42],"aspects":[43],"inert":[45],"micron-sized":[46],"particles,":[49],"or":[50,59],"MPIOs,":[51],"and":[52,65,80,108,137,139,207],"biodegradable":[53],"small":[54],"oxide,":[58],"SPIOs.":[60],"Practically,":[61],"nanoparticle":[63],"fabrication":[64,93],"storage":[66],"requires":[67],"some":[68],"form":[69],"cryoprotectant":[71],"both":[73],"protect":[74],"particle":[76],"during":[77,178],"freeze":[78,179],"drying":[79,180],"promote":[82],"resuspension.":[83],"While":[84],"this":[85,111,122],"is":[86,198],"commonly":[88],"employed":[89],"procedure":[90],"drug":[95],"loaded":[96],"nanoparticles,":[98],"it":[99],"has":[100],"yet":[101],"be":[103],"investigated":[104],"for":[105,141],"magnetic":[106,117,124,184,209],"what":[109],"effect":[110],"might":[112],"have":[113],"on":[114],"internalization":[115],"particles.":[118],"As":[119],"such,":[120],"study,":[123],"were":[127],"fabricated":[128],"with":[129,153,173,195],"various":[130],"concentrations":[131,176],"two":[133],"common":[134],"cryoprotectants,":[135],"dextrose":[136,197],"sucrose,":[138],"analyzed":[140],"their":[142],"ability":[143,159],"magnetically":[145],"label":[146],"cells.":[147],"It":[148],"was":[149,168],"found":[150],"cryoprotection":[152,194],"either":[154],"sugar":[155,171,175],"significantly":[156,182],"enhanced":[157],"resuspend":[161],"without":[163],"aggregation.":[164],"labeling":[167,186],"impacted":[169],"by":[170],"concentration,":[172],"higher":[174],"used":[177],"more":[181],"reducing":[183],"than":[187],"lower":[188],"concentrations.":[189],"These":[190],"studies":[191],"suggest":[192],"1%":[196],"optimal":[200],"compromise":[201],"preserves":[203],"monodispersity":[204],"following":[205],"resuspension":[206],"high":[208],"labeling.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
