{"id":"https://openalex.org/W2068627547","doi":"https://doi.org/10.1128/jb.184.10.2780-2788.2002","title":"The E1\u03b2 and E2 Subunits of theBacillus subtilisPyruvate Dehydrogenase Complex Are Involved in Regulation of Sporulation","display_name":"The E1\u03b2 and E2 Subunits of theBacillus subtilisPyruvate Dehydrogenase Complex Are Involved in Regulation of Sporulation","publication_year":2002,"publication_date":"2002-05-15","ids":{"openalex":"https://openalex.org/W2068627547","doi":"https://doi.org/10.1128/jb.184.10.2780-2788.2002","mag":"2068627547","pmid":"https://pubmed.ncbi.nlm.nih.gov/11976308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/135025"},"language":"en","primary_location":{"id":"doi:10.1128/jb.184.10.2780-2788.2002","doi":"https://doi.org/10.1128/jb.184.10.2780-2788.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.184.10.2780-2788.2002","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC135025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023568877","display_name":"Haichun Gao","orcid":"https://orcid.org/0000-0002-2647-6563","observed_orcids":["https://orcid.org/0000-0002-2647-6563"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haichun Gao","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047830370","display_name":"Xin Jian Jiang","orcid":"https://orcid.org/0000-0002-7288-8278","observed_orcids":["https://orcid.org/0000-0002-7288-8278"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Jiang","raw_affiliation_strings":["Division of Biology, University of California at San Diego, La Jolla, California 92093-0349"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, University of California at San Diego, La Jolla, California 92093-0349","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044562249","display_name":"Kit Pogliano","orcid":"https://orcid.org/0000-0002-7868-3345","observed_orcids":["https://orcid.org/0000-0002-7868-3345"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kit Pogliano","raw_affiliation_strings":["Division of Biology, University of California at San Diego, La Jolla, California 92093-0349"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, University of California at San Diego, La Jolla, California 92093-0349","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042153763","display_name":"Arthur I. Aronson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur I. Aronson","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1926,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.76517313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"184","issue":"10","first_page":"2780","last_page":"2788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.4487000107765198,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-complex","display_name":"pyruvate dehydrogenase complex","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sporulation","display_name":"sporulation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/e2-subunit","display_name":"E2 subunit","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dihydrolipoamide-acetyltransferase","display_name":"dihydrolipoamide acetyltransferase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/engulfment","display_name":"engulfment","score":0.5609999895095825},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.5189999938011169},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.7440000176429749},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.9319999814033508},{"id":"https://openalex.org/keywords/divalent-cations","display_name":"divalent cations","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8523334860801697},{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.7131919264793396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6905839443206787},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.6772149205207825},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6509720683097839},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.595032811164856},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.457006573677063},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32362014055252075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2491838037967682},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1577104926109314},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13645121455192566}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011768","descriptor_name":"Pyruvate Dehydrogenase Complex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013171","descriptor_name":"Spores, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013171","descriptor_name":"Spores, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030481","descriptor_name":"Pyruvate Dehydrogenase (Lipoamide)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051047","descriptor_name":"Dihydrolipoyllysine-Residue Acetyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.184.10.2780-2788.2002","doi":"https://doi.org/10.1128/jb.184.10.2780-2788.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.184.10.2780-2788.2002","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:131520","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC135025","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:11976308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11976308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:135025","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC135025/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:131520","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC135025","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2286433900","display_name":"Forespore engulfment during B. subtilis sporulation","funder_award_id":"R01GM057045","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7488176352","display_name":"Regulation of Protoxin Synthesis in Bacillus thuringiensis","funder_award_id":"9600584","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320309667","display_name":"Purdue Research Foundation","ror":"https://ror.org/007n03h88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W230311150","https://openalex.org/W280994533","https://openalex.org/W596970151","https://openalex.org/W609805730","https://openalex.org/W1488365067","https://openalex.org/W1489352271","https://openalex.org/W1489623763","https://openalex.org/W1503256853","https://openalex.org/W1546783991","https://openalex.org/W1582569793","https://openalex.org/W1589878029","https://openalex.org/W1605139332","https://openalex.org/W1640953885","https://openalex.org/W1649715668","https://openalex.org/W1678194650","https://openalex.org/W1763973057","https://openalex.org/W1784624442","https://openalex.org/W1788532922","https://openalex.org/W1870056855","https://openalex.org/W1945765509","https://openalex.org/W1973475435","https://openalex.org/W1974809133","https://openalex.org/W1984497246","https://openalex.org/W1985184396","https://openalex.org/W1985510734","https://openalex.org/W1990900166","https://openalex.org/W1991727789","https://openalex.org/W1998672450","https://openalex.org/W2003342215","https://openalex.org/W2022474924","https://openalex.org/W2048273594","https://openalex.org/W2049702106","https://openalex.org/W2066784077","https://openalex.org/W2079426078","https://openalex.org/W2096611984","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2119269209","https://openalex.org/W2123475271","https://openalex.org/W2126615679","https://openalex.org/W2138081694","https://openalex.org/W2144939042","https://openalex.org/W2151652896","https://openalex.org/W2152845055","https://openalex.org/W2155410528","https://openalex.org/W2156120104","https://openalex.org/W2156833220","https://openalex.org/W2158921274","https://openalex.org/W2161524167","https://openalex.org/W2165003344","https://openalex.org/W2214089962","https://openalex.org/W2334169074"],"related_works":["https://openalex.org/W7005532138","https://openalex.org/W2035502849","https://openalex.org/W69686664","https://openalex.org/W2073653450","https://openalex.org/W2334169074","https://openalex.org/W2416608103","https://openalex.org/W1984836110","https://openalex.org/W2017719469","https://openalex.org/W1640953885","https://openalex.org/W2064511231"],"abstract_inverted_index":{"The":[0,47,95,114,229],"pdhABCD":[1],"operon":[2,36],"of":[3,21,43,55,72,123,135,146,158,162,175,186,201,217,241,248,256],"Bacillus":[4],"subtilis":[5],"encodes":[6],"the":[7,22,34,44,56,73,124,128,136,143,147,173,184,192,198,209,215,238],"pyruvate":[8,23],"decarboxylase":[9],"(E1alpha":[10],"and":[11,16,37,58,69,76,107,116,149,179,231],"E1beta),":[12],"dihydrolipoamide":[13,17],"acetyltransferase":[14],"(E2),":[15],"dehydrogenase":[18,24],"(E3)":[19],"subunits":[20,160,233],"multienzyme":[25],"complex":[26],"(PDH).":[27],"There":[28],"are":[29,62,235],"two":[30],"promoters:":[31],"one":[32,40],"for":[33,253],"entire":[35],"an":[38,111],"internal":[39],"in":[41,64,110,197,237],"front":[42],"pdhC":[45,117,150,210],"gene.":[46],"latter":[48],"may":[49],"serve":[50],"to":[51,83,103,120,133,155,245],"ensure":[52],"adequate":[53],"quantities":[54],"E2":[57,232],"E3":[59],"subunits,":[60],"which":[61,234],"needed":[63],"greater":[65],"amounts":[66],"than":[67],"E1alpha":[68,92],"E1beta.":[70],"Disruptions":[71],"pdhB,":[74],"pdhC,":[75],"pdhD":[77,129],"genes":[78],"were":[79,88,101],"isolated,":[80],"but":[81,166],"attempts":[82],"construct":[84],"a":[85,156],"pdhA":[86],"mutant":[87,130,151,194,211],"unsuccessful,":[89],"suggesting":[90],"that":[91,142,191],"is":[93],"essential.":[94],"three":[96],"mutants":[97,118],"lacked":[98],"PDH":[99],"activity,":[100],"unable":[102],"grow":[104],"on":[105],"glucose":[106],"grew":[108],"poorly":[109],"enriched":[112],"medium.":[113],"pdhB":[115,148,193],"sporulated":[119,132],"only":[121],"5%":[122],"wild-type":[125,137],"level,":[126],"whereas":[127,208],"strain":[131],"55%":[134],"level.":[138],"This":[139,221],"difference":[140],"indicated":[141],"sporulation":[144],"defect":[145],"strains":[152],"was":[153,170,195,212,223],"due":[154],"function(s)":[157],"these":[159],"independent":[161],"enzymatic":[163,249],"activity.":[164],"Growth,":[165],"not":[167],"low":[168],"sporulation,":[169],"enhanced":[171],"by":[172,225],"addition":[174],"acetate,":[176],"glutamate,":[177],"succinate,":[178],"divalent":[180],"cations.":[181],"Results":[182],"from":[183],"expression":[185],"various":[187],"spo-lacZ":[188],"fusions":[189],"revealed":[190],"defective":[196],"late":[199],"stages":[200],"engulfment":[202,218],"or":[203],"membrane":[204,227],"fusion":[205],"(stage":[206,219],"II),":[207],"blocked":[213],"after":[214],"completion":[216],"III).":[220],"analysis":[222],"confirmed":[224],"fluorescent":[226],"staining.":[228],"E1beta":[230],"present":[236],"soluble":[239],"fraction":[240],"sporulating":[242],"cells":[243],"appear":[244],"function":[246],"independently":[247],"activity":[250],"as":[251],"checkpoints":[252],"stage":[254],"II-III":[255],"sporulation.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
