{"id":"https://openalex.org/W2068613645","doi":"https://doi.org/10.1097/00007691-198709000-00006","title":"Changes in Lignocaine Disposition during Long-Term Infusion in Patients with Acute Ventricular Arrhythmias","display_name":"Changes in Lignocaine Disposition during Long-Term Infusion in Patients with Acute Ventricular Arrhythmias","publication_year":1987,"publication_date":"1987-09-01","ids":{"openalex":"https://openalex.org/W2068613645","doi":"https://doi.org/10.1097/00007691-198709000-00006","mag":"2068613645","pmid":"https://pubmed.ncbi.nlm.nih.gov/3672571"},"language":"en","primary_location":{"id":"doi:10.1097/00007691-198709000-00006","doi":"https://doi.org/10.1097/00007691-198709000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-198709000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045334477","display_name":"Alison H. Thomson","orcid":"https://orcid.org/0000-0002-2354-6116","observed_orcids":["https://orcid.org/0000-0002-2354-6116"]},"institutions":[{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alison H. Thomson","raw_affiliation_strings":["Department of Materia Medica, University of Glasgow, Stobhill General Hospital, Scotland","Materia Medica and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materia Medica, University of Glasgow, Stobhill General Hospital, Scotland","institution_ids":["https://openalex.org/I2802797558","https://openalex.org/I7882870"]},{"raw_affiliation_string":"Materia Medica and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111948058","display_name":"Andrew W. Kelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew W. Kelman","raw_affiliation_strings":["Clinical Physics and Bioengineering, University of Glasgow, Slobhill General Hospital, Glasgow, Scotland","Materia Medica and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Physics and Bioengineering, University of Glasgow, Slobhill General Hospital, Glasgow, Scotland","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"Materia Medica and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061510057","display_name":"Philip J. de Vane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Philip J. de Vane","raw_affiliation_strings":["Materia Medica and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materia Medica and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022442393","display_name":"W S Hillis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"W. Stewart Hillis","raw_affiliation_strings":["Materia Medica and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materia Medica and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034714525","display_name":"Brian Whiting","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brian Whiting","raw_affiliation_strings":["Materia Medica and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materia Medica and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022442393","https://openalex.org/A5034714525","https://openalex.org/A5045334477","https://openalex.org/A5061510057","https://openalex.org/A5111948058"],"corresponding_institution_ids":["https://openalex.org/I2802797558","https://openalex.org/I7882870"],"apc_list":null,"apc_paid":null,"fwci":0.6611,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.64021018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"3","first_page":"283","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/procainamide","display_name":"procainamide","score":0.7110000252723694},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/prolonged-infusion","display_name":"prolonged infusion","score":0.7490000128746033},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.871999979019165},{"id":"https://openalex.org/keywords/alpha-1-acid-glycoprotein","display_name":"alpha-1-acid glycoprotein","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.8579999804496765},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.781000018119812},{"id":"https://openalex.org/keywords/bayesian-parameter-estimation","display_name":"Bayesian parameter estimation","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.7307192087173462},{"id":"https://openalex.org/C38022665","wikidata":"https://www.wikidata.org/wiki/Q1149305","display_name":"Disposition","level":2,"score":0.7138607501983643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6316473484039307},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5345517992973328},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5258408188819885},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5228983759880066},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.4104684889316559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37420207262039185},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32539159059524536},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009961","descriptor_name":"Orosomucoid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007691-198709000-00006","doi":"https://doi.org/10.1097/00007691-198709000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-198709000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:3672571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3672571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089587495","https://openalex.org/W1531062229","https://openalex.org/W2010687472","https://openalex.org/W2002424339","https://openalex.org/W2084326462","https://openalex.org/W1998119725","https://openalex.org/W2010303268","https://openalex.org/W1970121118","https://openalex.org/W1994525860","https://openalex.org/W2052432072"],"abstract_inverted_index":{"Lignocaine":[0,58],"disposition":[1,165],"was":[2,60,75,86,112],"studied":[3],"in":[4,43,56,90,115,156],"30":[5],"patients":[6,44,116],"with":[7,45,103],"acute":[8,46],"ventricular":[9],"arrhythmias.":[10],"Serum":[11],"concentrations":[12,39],"of":[13,53,82,99,130,145],"lignocaine,":[14],"its":[15],"metabolites":[16],"Monoethylglycine":[17],"xylidide":[18,22],"(MEGX)":[19],"and":[20,24,32,74,121,147],"glycine":[21],"(GX),":[23],"alpha":[25],"1-acid":[26],"glycoprotein":[27],"(AAG)":[28],"were":[29],"analyzed":[30],"during":[31,65,106,166],"after":[33],"a":[34,69,87,142],"48-h":[35],"lignocaine":[36,164],"infusion.":[37,84,168],"AAG":[38,148],"tended":[40],"to":[41,51,77,158],"rise":[42],"myocardial":[47],"infarction":[48],"(AMI),":[49],"leading":[50],"binding":[52,160],"the":[54,66,80,83,97,100,107,131],"drug":[55],"plasma.":[57],"clearance":[59,91,132],"estimated":[61],"at":[62,96],"various":[63],"times":[64],"infusion":[67,101],"using":[68],"Bayesian":[70],"parameter":[71],"estimation":[72],"program":[73],"found":[76],"decline":[78],"over":[79],"course":[81],"There":[85],"significant":[88],"reduction":[89],"based":[92],"on":[93],"estimates":[94,104],"obtained":[95,105],"end":[98],"compared":[102],"first":[108],"0-5":[109],"h.":[110],"Clearance":[111],"reduced":[113],"both":[114],"who":[117,123],"had":[118],"an":[119],"AMI":[120],"those":[122],"did":[124],"not.":[125],"Multiple":[126],"linear":[127,143],"regression":[128],"analysis":[129],"data":[133],"revealed":[134],"that":[135,153],"these":[136],"changes":[137,161],"could":[138],"be":[139],"described":[140],"by":[141],"function":[144],"time":[146],"concentration.":[149],"These":[150],"findings":[151],"suggest":[152],"other":[154],"factors":[155],"addition":[157],"protein":[159],"may":[162],"influence":[163],"long-term":[167]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}