{"id":"https://openalex.org/W2068599650","doi":"https://doi.org/10.1371/journal.pone.0091173","title":"High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27Kip1 Transcriptional Inhibitor","display_name":"High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27Kip1 Transcriptional Inhibitor","publication_year":2014,"publication_date":"2014-03-19","ids":{"openalex":"https://openalex.org/W2068599650","doi":"https://doi.org/10.1371/journal.pone.0091173","mag":"2068599650","pmid":"https://pubmed.ncbi.nlm.nih.gov/24646893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3960108"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0091173","doi":"https://doi.org/10.1371/journal.pone.0091173","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0091173","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0091173&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0091173&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066243490","display_name":"Brandon J. Walters","orcid":"https://orcid.org/0000-0002-8073-6573","observed_orcids":["https://orcid.org/0000-0002-8073-6573"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon J. Walters","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074928025","display_name":"Wenwei Lin","orcid":"https://orcid.org/0000-0001-8754-6150","observed_orcids":["https://orcid.org/0000-0001-8754-6150"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenwei Lin","raw_affiliation_strings":["Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022518299","display_name":"Shiyong Diao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiyong Diao","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088662063","display_name":"Mark A. Brimble","orcid":"https://orcid.org/0000-0001-7182-9818","observed_orcids":["https://orcid.org/0000-0001-7182-9818"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I51601045","display_name":"University of Bath","ror":"https://ror.org/002h8g185","country_code":"GB","type":"education","lineage":["https://openalex.org/I51601045"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Mark Brimble","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America; University of Bath, Bath, United Kingdom","Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","University of Bath, Bath, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America; University of Bath, Bath, United Kingdom","institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I51601045"]},{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"University of Bath, Bath, United Kingdom","institution_ids":["https://openalex.org/I51601045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089534060","display_name":"Luigi I. Iconaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luigi I. Iconaru","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088435754","display_name":"Jennifer Dearman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Dearman","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089267841","display_name":"Asli N. Goktug","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asli Goktug","raw_affiliation_strings":["Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004064976","display_name":"Taosheng Chen","orcid":"https://orcid.org/0000-0001-6420-3809","observed_orcids":["https://orcid.org/0000-0001-6420-3809"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taosheng Chen","raw_affiliation_strings":["Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100657071","display_name":"Jian Zuo","orcid":"https://orcid.org/0000-0002-1448-4507","observed_orcids":["https://orcid.org/0000-0002-1448-4507","https://orcid.org/0009-0007-6278-6335","https://orcid.org/0000-0002-5395-2887"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian Zuo","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100657071"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.6072,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83984053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"3","first_page":"e91173","last_page":"e91173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/transcription-inhibitors","display_name":"transcription inhibitors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.8799999952316284},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.722000002861023},{"id":"https://openalex.org/keywords/cell-cycle-inhibitors","display_name":"cell cycle inhibitors","score":0.5699999928474426},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6119999885559082},{"id":"https://openalex.org/keywords/fda-approved-compounds","display_name":"FDA-approved compounds","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4733674228191376},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.4329446852207184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3928912878036499},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38361990451812744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32699865102767944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15494132041931152},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071316","descriptor_name":"Forkhead Box Protein O3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0091173","doi":"https://doi.org/10.1371/journal.pone.0091173","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0091173","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0091173&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2941596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3960108","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3960108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3960108","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24646893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24646893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:44ba25b122d14e03b276ced1a7ef8902","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/44ba25b122d14e03b276ced1a7ef8902","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 3, p e91173 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0091173","doi":"https://doi.org/10.1371/journal.pone.0091173","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0091173","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0091173&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G164415112","display_name":null,"funder_award_id":"DC06471","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G165480143","display_name":"Genetic analysis of mammalian hearing sensitivity","funder_award_id":"R01DC006471","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G2649222700","display_name":null,"funder_award_id":"N000141210775","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G4856111422","display_name":null,"funder_award_id":"N000140911014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G609259107","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G634941651","display_name":null,"funder_award_id":"GM086415","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7372847108","display_name":"Drug discovery for hair cell regeneration in adult mammalian cochleae","funder_award_id":"R21DC013879","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G7512089370","display_name":"Regulation of PXR by cell cycle and phosphorylation","funder_award_id":"R01GM086415","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G751896108","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320310040","funder_display_name":"St. Jude Children's Research Hospital"},{"id":"https://openalex.org/G8281456828","display_name":null,"funder_award_id":"N000141210191","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G865138149","display_name":null,"funder_award_id":"CA 21765","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G8798575617","display_name":null,"funder_award_id":"GM086415","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G9000086855","display_name":null,"funder_award_id":"CA21765)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068599650.pdf","grobid_xml":"https://content.openalex.org/works/W2068599650.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1596659824","https://openalex.org/W1919908042","https://openalex.org/W1965049479","https://openalex.org/W1968132748","https://openalex.org/W1971181044","https://openalex.org/W1971757408","https://openalex.org/W1977112537","https://openalex.org/W1977372249","https://openalex.org/W1978034376","https://openalex.org/W1986127962","https://openalex.org/W1987604649","https://openalex.org/W1998914462","https://openalex.org/W2001106689","https://openalex.org/W2008364371","https://openalex.org/W2009455776","https://openalex.org/W2013341702","https://openalex.org/W2015066175","https://openalex.org/W2021064677","https://openalex.org/W2026715413","https://openalex.org/W2049283940","https://openalex.org/W2059004428","https://openalex.org/W2063203910","https://openalex.org/W2063821942","https://openalex.org/W2088357355","https://openalex.org/W2098102650","https://openalex.org/W2100706309","https://openalex.org/W2101825119","https://openalex.org/W2108197605","https://openalex.org/W2110710127","https://openalex.org/W2121771679","https://openalex.org/W2139829576","https://openalex.org/W2140945785","https://openalex.org/W2146651319","https://openalex.org/W2167121336","https://openalex.org/W2170737868","https://openalex.org/W2171391341","https://openalex.org/W4243451547","https://openalex.org/W4298017530"],"related_works":["https://openalex.org/W2062136986","https://openalex.org/W1553035821","https://openalex.org/W2105323766","https://openalex.org/W2804357002","https://openalex.org/W2051760228","https://openalex.org/W1596659824","https://openalex.org/W4236686679","https://openalex.org/W1976369107","https://openalex.org/W7005758230","https://openalex.org/W1996413533"],"abstract_inverted_index":{"p27Kip1":[0,17,28,58,74,83,94,108,120,191,210,219,233],"is":[1,18,43,84,96],"a":[2,19,46,101,113,131,139,181],"cell":[3,70],"cycle":[4],"inhibitor":[5],"that":[6,73,197],"prevents":[7],"cyclin":[8],"dependent":[9],"kinase":[10],"(CDK)/cyclin":[11],"complexes":[12],"from":[13,215],"phosphorylating":[14],"their":[15],"targets.":[16],"known":[20],"tumor":[21],"suppressor,":[22],"as":[23,130],"the":[24,93,119,171,218,226],"germline":[25],"loss":[26,56],"of":[27,45,57,68,92,143,148,173,183,225,232],"results":[29,59],"in":[30,34,40,54,60,63],"sporadic":[31],"pituitary":[32],"formation":[33],"aged":[35],"rodents,":[36],"and":[37,66,127,153,194,234],"its":[38,52],"presence":[39],"human":[41],"cancers":[42],"indicative":[44],"poor":[47],"prognosis.":[48],"In":[49],"addition":[50],"to":[51,105,122,217,229],"role":[53],"cancer,":[55],"regenerative":[61],"phenotypes":[62],"some":[64],"tissues":[65],"maintenance":[67],"stem":[69],"pluripotency,":[71],"suggesting":[72],"inhibitors":[75,91,231],"could":[76],"be":[77],"beneficial":[78],"for":[79,134,238],"tissue":[80,240],"regeneration.":[81],"Because":[82],"an":[85],"intrinsically":[86],"disordered":[87],"protein,":[88],"identifying":[89],"direct":[90],"protein":[95],"difficult.":[97],"Therefore,":[98],"we":[99,161,187],"pursued":[100],"high-throughput":[102],"screening":[103],"strategy":[104],"identify":[106,230],"novel":[107,190],"transcriptional":[109,192],"inhibitors.":[110],"We":[111,137],"utilized":[112],"luciferase":[114],"reporter":[115],"plasmid":[116],"driven":[117],"by":[118,212],"promoter":[121,172],"transiently":[123],"transfect":[124],"HeLa":[125],"cells":[126],"used":[128],"cyclohexamide":[129],"positive":[132],"control":[133],"non-specific":[135],"inhibition.":[136],"screened":[138],"\"bioactive\"":[140],"library":[141],"consisting":[142],"8,904":[144],"(4,359":[145],"unique)":[146],"compounds,":[147],"which":[149],"830":[150],"are":[151],"Food":[152],"Drug":[154],"Administration":[155],"(FDA)":[156],"approved.":[157],"From":[158],"this":[159],"screen,":[160],"successfully":[162],"identified":[163],"111":[164],"primary":[165],"hits":[166,176],"with":[167],"inhibitory":[168],"effect":[169],"against":[170],"p27Kip1.":[174],"These":[175],"were":[177],"further":[178,195],"refined":[179],"using":[180],"battery":[182],"secondary":[184],"screens.":[185],"Here":[186],"report":[188],"four":[189],"inhibitors,":[193],"demonstrate":[196],"our":[198],"most":[199],"potent":[200],"hit":[201],"compound":[202],"(IC50":[203],"=":[204],"200":[205],"nM)":[206],"Alsterpaullone":[207],"2-cyanoethyl,":[208],"inhibits":[209],"transcription":[211],"preventing":[213],"FoxO3a":[214],"binding":[216],"promoter.":[220],"This":[221],"screen":[222],"represents":[223],"one":[224],"first":[227],"attempts":[228],"may":[235],"prove":[236],"useful":[237],"future":[239],"regeneration":[241],"studies.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
