{"id":"https://openalex.org/W2068413630","doi":"https://doi.org/10.1271/bbb.70.203","title":"Activation of Murine Peritoneal Macrophages by Water-Soluble Extracts ofBursaphelenchus xylophilus, a Pine Wood Nematode","display_name":"Activation of Murine Peritoneal Macrophages by Water-Soluble Extracts ofBursaphelenchus xylophilus, a Pine Wood Nematode","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2068413630","doi":"https://doi.org/10.1271/bbb.70.203","mag":"2068413630","pmid":"https://pubmed.ncbi.nlm.nih.gov/16428838"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.70.203","doi":"https://doi.org/10.1271/bbb.70.203","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.70.203","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040636868","display_name":"Hiroaki Kaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki KAJI","raw_affiliation_strings":["Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan","Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021305168","display_name":"Akihiro Tai","orcid":"https://orcid.org/0000-0003-0285-1469","observed_orcids":["https://orcid.org/0000-0003-0285-1469"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro TAI","raw_affiliation_strings":["Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101021195","display_name":"Kazufumi Matsushita","orcid":"https://orcid.org/0009-0008-7384-8762","observed_orcids":["https://orcid.org/0009-0008-7384-8762"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazufumi MATSUSHITA","raw_affiliation_strings":["Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027774777","display_name":"Hiroshi Kanzaki","orcid":"https://orcid.org/0000-0002-9506-3519","observed_orcids":["https://orcid.org/0000-0002-9506-3519"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi KANZAKI","raw_affiliation_strings":["Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112667608","display_name":"Itaru Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Itaru YAMAMOTO","raw_affiliation_strings":["Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.2327886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"70","issue":"1","first_page":"203","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11179","display_name":"Nematode management and characterization studies","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11179","display_name":"Nematode management and characterization studies","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.19089999794960022,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bursaphelenchus-xylophilus","display_name":"Bursaphelenchus xylophilus","score":1.0},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9769999980926514},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9020000100135803},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/pine-wilt-disease","display_name":"pine wilt disease","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2779442720","wikidata":"https://www.wikidata.org/wiki/Q1197786","display_name":"Bursaphelenchus xylophilus","level":3,"score":0.9393938779830933},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.7875266075134277},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.6619610786437988},{"id":"https://openalex.org/C2776857380","wikidata":"https://www.wikidata.org/wiki/Q19698073","display_name":"Xylophilus","level":4,"score":0.5794987082481384},{"id":"https://openalex.org/C2778830712","wikidata":"https://www.wikidata.org/wiki/Q5185","display_name":"Nematode","level":2,"score":0.5726263523101807},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.557025134563446},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5224546194076538},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49287939071655273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46732962131500244},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.45530006289482117},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.42043739557266235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37861883640289307},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3612428307533264},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3430154323577881},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31040099263191223},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10752177238464355},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.050211578607559204},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009348","descriptor_name":"Nematoda","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009566","descriptor_name":"Nitrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013864","descriptor_name":"Thioglycolates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014020","descriptor_name":"Tissue Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028223","descriptor_name":"Pinus","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.70.203","doi":"https://doi.org/10.1271/bbb.70.203","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.70.203","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:16428838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16428838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W83564413","https://openalex.org/W136693327","https://openalex.org/W193675779","https://openalex.org/W1485155205","https://openalex.org/W1532725606","https://openalex.org/W1535889588","https://openalex.org/W1539033471","https://openalex.org/W1558398732","https://openalex.org/W1573617710","https://openalex.org/W1574330564","https://openalex.org/W1589419507","https://openalex.org/W1594268419","https://openalex.org/W1834041853","https://openalex.org/W1969806712","https://openalex.org/W1977429862","https://openalex.org/W1977761851","https://openalex.org/W1981882818","https://openalex.org/W1994389040","https://openalex.org/W2001986012","https://openalex.org/W2003499486","https://openalex.org/W2007571231","https://openalex.org/W2009243108","https://openalex.org/W2023047141","https://openalex.org/W2036663468","https://openalex.org/W2041479453","https://openalex.org/W2061342326","https://openalex.org/W2064645651","https://openalex.org/W2073132923","https://openalex.org/W2081543069","https://openalex.org/W2082922121","https://openalex.org/W2094460752","https://openalex.org/W2103496672","https://openalex.org/W2110995507","https://openalex.org/W2123062093","https://openalex.org/W2127952767","https://openalex.org/W2158947161","https://openalex.org/W2159069239","https://openalex.org/W2164230114","https://openalex.org/W2396356945"],"related_works":["https://openalex.org/W2009243108","https://openalex.org/W2768271583","https://openalex.org/W809417593","https://openalex.org/W1998220981","https://openalex.org/W2122311716","https://openalex.org/W7009306976","https://openalex.org/W3121164328","https://openalex.org/W2110995507","https://openalex.org/W1582650055","https://openalex.org/W1968377922"],"abstract_inverted_index":{"In":[0,56],"our":[1],"previous":[2],"study,":[3],"water-soluble":[4],"extracts":[5,49,96,124],"from":[6],"Bursaphelenchus":[7],"xylophilus":[8,70,95,127],"(B.":[9],"xylophilus),":[10],"a":[11],"pine":[12],"wood":[13],"nematode,":[14],"were":[15],"shown":[16],"to":[17,33],"enhance":[18],"interleukin":[19],"(IL)-4":[20],"plus":[21],"lipopolysaccharide-induced":[22],"polyclonal":[23,141],"immunoglobulin":[24],"(Ig)":[25],"E":[26],"production":[27,100,109],"in":[28,30,41,87,101,116,134],"vitro":[29],"mice":[31],"and":[32,59,106,110],"increase":[34,86],"serum":[35],"levels":[36],"of":[37,52,79,90,104,113,125],"an":[38,85,129,137],"antigen-nonspecific":[39],"IgE":[40,142],"vivo.":[42],"Here":[43],"we":[44],"examined":[45],"whether":[46],"the":[47,88,123],"nematode":[48],"stimulate":[50],"immunofunctions":[51,133],"murine":[53],"peritoneal":[54],"macrophages.":[55,118],"both":[57,102],"resident":[58],"inflammatory":[60,114,117],"macrophages,":[61,105,135],"Fcgamma":[62],"receptor-mediated":[63],"phagocytosis":[64,74,81],"was":[65,75,82],"markedly":[66],"activated":[67],"by":[68,84],"B.":[69,94,126],"extracts,":[71],"while":[72],"non-specific":[73],"not.":[76],"The":[77],"enhancement":[78],"specific":[80],"accompanied":[83],"formation":[89],"IgG-Fcgamma":[91],"receptor":[92],"rosettes.":[93],"also":[97],"stimulated":[98],"IL-1beta":[99],"types":[103],"enhanced":[107],"NO":[108],"mRNA":[111],"expression":[112],"cytokines":[115],"These":[119],"results":[120],"indicate":[121],"that":[122],"contain":[128],"activating":[130],"substance(s)":[131],"for":[132,140],"besides":[136],"enhancing":[138],"factor":[139],"production.":[143]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}