{"id":"https://openalex.org/W2068366262","doi":"https://doi.org/10.1002/pbc.24026","title":"Analysis of pediatric autologous PBSC apheresis and transplant: Age is a major factor affecting post\u2010transplant toxicity","display_name":"Analysis of pediatric autologous PBSC apheresis and transplant: Age is a major factor affecting post\u2010transplant toxicity","publication_year":2011,"publication_date":"2011-12-16","ids":{"openalex":"https://openalex.org/W2068366262","doi":"https://doi.org/10.1002/pbc.24026","mag":"2068366262","pmid":"https://pubmed.ncbi.nlm.nih.gov/22180259"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.24026","doi":"https://doi.org/10.1002/pbc.24026","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.24026","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083621673","display_name":"Leonid Dubrovsky","orcid":"https://orcid.org/0000-0003-2799-4765","observed_orcids":["https://orcid.org/0000-0003-2799-4765"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonid Dubrovsky","raw_affiliation_strings":["Pediatric Residency Program, Children's National Medical Center, Washington, District of Columbia, USA. ldubrov@gmail.com","Pediatric Residency Program, Children's National Medical Center, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Residency Program, Children's National Medical Center, Washington, District of Columbia, USA. ldubrov@gmail.com","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Pediatric Residency Program, Children's National Medical Center, Washington, District of Columbia","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056786004","display_name":"Robert McCarter","orcid":"https://orcid.org/0000-0002-7911-6078","observed_orcids":["https://orcid.org/0000-0002-7911-6078"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. McCarter","raw_affiliation_strings":["Center for Clinical, Community Research, Children's Research Institute, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical, Community Research, Children's Research Institute, Washington, District of Columbia","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017207916","display_name":"Terry J. Fry","orcid":"https://orcid.org/0000-0001-8044-5226","observed_orcids":["https://orcid.org/0000-0001-8044-5226"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry J. Fry","raw_affiliation_strings":["Division of Blood & Marrow Transplant, Children's National Medical Center, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood & Marrow Transplant, Children's National Medical Center, Washington, District of Columbia","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066837873","display_name":"Edward C.C. Wong","orcid":"https://orcid.org/0000-0001-7645-4277","observed_orcids":["https://orcid.org/0000-0001-7645-4277"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Wong","raw_affiliation_strings":["Division of Laboratory Medicine, Children's National Medical Center, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Laboratory Medicine, Children's National Medical Center, Washington, District of Columbia","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103656334","display_name":"Yao Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yao Cheng","raw_affiliation_strings":["Center for Clinical, Community Research, Children's Research Institute, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical, Community Research, Children's Research Institute, Washington, District of Columbia","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071440177","display_name":"Evelio D. Perez\u2010Albuerne","orcid":"https://orcid.org/0000-0001-6159-9510","observed_orcids":["https://orcid.org/0000-0001-6159-9510"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelio D. Perez\u2010Albuerne","raw_affiliation_strings":["Division of Blood & Marrow Transplant, Children's National Medical Center, Washington, District of Columbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood & Marrow Transplant, Children's National Medical Center, Washington, District of Columbia","institution_ids":["https://openalex.org/I1336742384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083621673"],"corresponding_institution_ids":["https://openalex.org/I1336742384"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.14649829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"59","issue":"2","first_page":"301","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/peripheral-blood-stem-cell-apheresis","display_name":"peripheral blood stem cell apheresis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.734000027179718},{"id":"https://openalex.org/keywords/transplant-related-toxicity","display_name":"transplant toxicity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cd34-cell-count","display_name":"CD34+ cell count","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neutrophil-engraftment","display_name":"neutrophil engraftment","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/intensive-care-unit-admission","display_name":"intensive care unit admission","score":0.9229999780654907},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.6079999804496765},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.949068009853363},{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.6806116104125977},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5812427401542664},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.529426634311676},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4842481315135956},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4824603199958801},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.4231409430503845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4050202965736389},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.08987703919410706},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.08182314038276672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036102","descriptor_name":"Peripheral Blood Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pbc.24026","doi":"https://doi.org/10.1002/pbc.24026","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.24026","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},{"id":"pmid:22180259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22180259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W232095477","https://openalex.org/W1503883962","https://openalex.org/W1965891829","https://openalex.org/W1967256155","https://openalex.org/W1993954120","https://openalex.org/W2002703500","https://openalex.org/W2003611808","https://openalex.org/W2006322160","https://openalex.org/W2011593776","https://openalex.org/W2023032576","https://openalex.org/W2032469010","https://openalex.org/W2047411633","https://openalex.org/W2056550360","https://openalex.org/W2064440155","https://openalex.org/W2066101699","https://openalex.org/W2078578013","https://openalex.org/W2086532935","https://openalex.org/W2088059778","https://openalex.org/W2092299911","https://openalex.org/W2092655604","https://openalex.org/W2110976794","https://openalex.org/W2111130338","https://openalex.org/W2122630246","https://openalex.org/W2154842787","https://openalex.org/W2159375259","https://openalex.org/W2162463856","https://openalex.org/W2411821226","https://openalex.org/W2797482815","https://openalex.org/W2977606681","https://openalex.org/W4233606916","https://openalex.org/W4246809787"],"related_works":["https://openalex.org/W2035878174","https://openalex.org/W6995978608","https://openalex.org/W7005377439","https://openalex.org/W2398041697","https://openalex.org/W3150283071","https://openalex.org/W2132118304","https://openalex.org/W2575967640","https://openalex.org/W1976407139","https://openalex.org/W4400984481","https://openalex.org/W2913390687"],"abstract_inverted_index":{"BACKGROUND:":[0],"High-dose":[1],"chemotherapy":[2,127],"followed":[3],"by":[4,211],"autologous":[5,52,69,249],"hematopoietic":[6],"cell":[7,142,145],"transplantation":[8],"(HCT)":[9],"is":[10,28],"used":[11,80],"in":[12,168,175],"many":[13],"therapeutic":[14],"protocols":[15],"for":[16,73,187,233],"pediatric":[17],"intra-":[18],"and":[19,37,97,111,129,134,143,150,156,174,190,240],"extra-cranial":[20],"solid":[21,41],"tumors.":[22],"HCT":[23,250],"can":[24],"be":[25],"curative,":[26],"but":[27],"associated":[29],"with":[30,224],"significant":[31],"toxicity.":[32],"PROCEDURE:":[33],"Between":[34],"January":[35],"2001":[36],"June":[38],"2009,":[39],"92":[40],"tumor":[42,125],"patients":[43,170,177,219],"(age":[44],"6":[45],"months":[46],"to":[47,81,86,103,113,148,183,195,205,237],"27":[48],"years)":[49],"underwent":[50,67],"94":[51],"apheresis":[53],"procedures":[54],"at":[55,230],"Children's":[56],"National":[57],"Medical":[58],"Center.":[59],"Out":[60],"of":[61,152,228],"that":[62],"group,":[63],"71":[64],"patients,":[65],"who":[66],"162":[68],"HCT,":[70],"were":[71,115],"analyzed":[72],"transplant":[74,87,222],"outcomes.":[75],"Multiple":[76],"variable":[77],"modeling":[78],"was":[79,165,192,209],"identify":[82],"independent":[83],"variables":[84,119,122,138],"related":[85,194],"toxicity":[88,164],"outcome":[89,100],"measures,":[90],"such":[91],"as":[92],"bacteremia,":[93,235],"intensive":[94,238],"care":[95],"admission,":[96],"death.":[98,241],"Other":[99],"measures":[101],"(time":[102],"pre-apheresis":[104,208],"peripheral":[105],"blood":[106,141],"CD34+":[107,144,157,197,206],"count,":[108],"product":[109],"yield,":[110],"time":[112,182,204],"engraftment)":[114],"also":[116],"analyzed.":[117],"Independent":[118],"included":[120],"patient-specific":[121],"(age,":[123],"weight,":[124,188],"type,":[126],"administered,":[128],"primary":[130],"vs.":[131],"relapsed":[132],"disease)":[133],"harvest":[135],"or":[136],"transplant-related":[137],"(total":[139],"white":[140],"counts":[146],"prior":[147],"transplant,":[149],"quantity":[151],"total":[153],"nucleated":[154],"cells":[155,158],"infused":[159,199],"during":[160],"transplant).":[161],"RESULTS:":[162],"Transplant":[163],"significantly":[166],"greater":[167],"younger":[169],"(P":[171,178,200,214],"=":[172,179,201,215],"0.001)":[173],"neuroblastoma":[176],"0.003).":[180],"The":[181,203],"neutrophil":[184,252],"engraftment,":[185],"controlling":[186],"age,":[189],"chemotherapy,":[191],"positively":[193],"absolute":[196],"cells/kg":[198],"0.01).":[202],"recovery":[207],"affected":[210],"patient":[212],"diagnosis":[213],"0.05).":[216],"CONCLUSIONS:":[217],"Younger":[218],"had":[220],"increased":[221],"toxicity,":[223],"infants":[225],"<1":[226],"year":[227],"age":[229],"highest":[231],"risk":[232],"fever,":[234],"admission":[236],"care,":[239],"Infants":[242],"would":[243],"likely":[244],"benefit":[245],"from":[246],"hospitalization":[247],"after":[248],"until":[251],"recovery.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
