{"id":"https://openalex.org/W2068308778","doi":"https://doi.org/10.1128/aac.25.4.408","title":"Comparative efficacies of mezlocillin and ampicillin alone or in combination with gentamicin in the treatment of Streptococcus faecalis endocarditis in rabbits","display_name":"Comparative efficacies of mezlocillin and ampicillin alone or in combination with gentamicin in the treatment of Streptococcus faecalis endocarditis in rabbits","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2068308778","doi":"https://doi.org/10.1128/aac.25.4.408","mag":"2068308778","pmid":"https://pubmed.ncbi.nlm.nih.gov/6428306","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/185540"},"language":"en","primary_location":{"id":"doi:10.1128/aac.25.4.408","doi":"https://doi.org/10.1128/aac.25.4.408","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.25.4.408","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/185540","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109313287","display_name":"Robert J. Fass","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Fass","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"C A Wright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8209,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.75133236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"25","issue":"4","first_page":"408","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mezlocillin","display_name":"mezlocillin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":1.0},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/infective-endocarditis","display_name":"infective endocarditis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cardiac-vegetation","display_name":"cardiac vegetation","score":0.765999972820282},{"id":"https://openalex.org/keywords/serum-antibacterial-activity","display_name":"serum antibacterial activity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.9169116020202637},{"id":"https://openalex.org/C2776536040","wikidata":"https://www.wikidata.org/wiki/Q3307752","display_name":"Mezlocillin","level":5,"score":0.9125245809555054},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.8887394070625305},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.543249249458313},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5383812785148621},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.4880589246749878},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.44534438848495483},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4158974885940552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4039821922779083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2830769419670105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20053210854530334},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.1468510925769806},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08242407441139221},{"id":"https://openalex.org/C2778193466","wikidata":"https://www.wikidata.org/wiki/Q423787","display_name":"Piperacillin","level":4,"score":0.05682989954948425},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008802","descriptor_name":"Mezlocillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.25.4.408","doi":"https://doi.org/10.1128/aac.25.4.408","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.25.4.408","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:185540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/185540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:6428306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6428306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:185540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/185540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1456990981","https://openalex.org/W1983340139","https://openalex.org/W1993299849","https://openalex.org/W2007334715","https://openalex.org/W2028590419","https://openalex.org/W2084464728","https://openalex.org/W2127011406","https://openalex.org/W2146464771"],"related_works":["https://openalex.org/W2175049692","https://openalex.org/W1568620301","https://openalex.org/W2044851168","https://openalex.org/W2041828654","https://openalex.org/W2106411837","https://openalex.org/W2070610877","https://openalex.org/W2061193364","https://openalex.org/W2143662443","https://openalex.org/W2169610296","https://openalex.org/W2006316976"],"abstract_inverted_index":{"The":[0],"in":[1,4,13,86,127,150,182,213,220],"vitro":[2],"and":[3,9,12,26,139,166,177],"vivo":[5],"activities":[6,27],"of":[7,31,78,216],"mezlocillin":[8,37,51,101,159,190],"ampicillin,":[10,96],"alone":[11],"combination":[14],"with":[15,95,157,189,196],"gentamicin,":[16,100,103,161],"against":[17],"Streptococcus":[18],"faecalis":[19,33,218],"were":[20,34,90,115,171,187],"compared.":[21],"In":[22],"vitro,":[23],"relative":[24],"bactericidal":[25,178],"for":[28,107],"10":[29],"strains":[30,80],"S.":[32,217],"as":[35],"follows:":[36],"plus":[38,43,99,102,160,164],"gentamicin":[39,44,65,165],"greater":[40,49,56,63,70],"than":[41,50,54,57,61,64,68,71,75,123,134,144,195,204,211],"ampicillin":[42,58,98,119,163,197,212],"(P":[45,52,59,66,73,132,142,202],"is":[46],"not":[47,172],"significant)":[48],"less":[53,60,67,74,121,133,143,203],"0.01)":[55,62,69],"control":[72],"0.01).":[76,205],"One":[77],"the":[79,116,124,214],"was":[81,120],"used":[82],"to":[83],"induce":[84],"endocarditis":[85],"rabbits.":[87],"Infected":[88],"rabbits":[89,155],"treated":[91,156],"by":[92],"random":[93],"selection":[94],"mezlocillin,":[97,158],"or":[104,162,192,199],"saline":[105],"(control)":[106],"7":[108,170],"days.":[109],"Among":[110],"antibiotic-treated":[111],"rabbits,":[112],"survival":[113],"rates":[114],"same,":[117],"but":[118],"effective":[122,210],"other":[125],"regimens":[126],"sterilizing":[128],"both":[129],"blood":[130],"cultures":[131,153],"0.001":[135],"on":[136,146,168],"day":[137,147,169],"4)":[138],"cardiac":[140],"vegetations":[141],"0.05":[145],"7).":[148],"Differences":[149],"quantitative":[151],"vegetation":[152],"among":[154],"sacrificed":[167],"significantly":[173],"different.":[174],"Peak":[175],"inhibitory":[176],"antibacterial":[179],"activity":[180],"titers":[181],"serum":[183],"determined":[184],"during":[185],"treatment":[186,215],"higher":[188],"(with":[191,198],"without":[193,200],"gentamicin)":[194,201],"Mezlocillin":[206],"may":[207],"be":[208],"more":[209],"infections":[219],"humans.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}