{"id":"https://openalex.org/W2068305560","doi":"https://doi.org/10.1186/2045-3701-1-11","title":"The Role of XPG in Processing (CAG)n/(CTG)n DNA Hairpins","display_name":"The Role of XPG in Processing (CAG)n/(CTG)n DNA Hairpins","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2068305560","doi":"https://doi.org/10.1186/2045-3701-1-11","mag":"2068305560","pmid":"https://pubmed.ncbi.nlm.nih.gov/21711735","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3125201"},"language":"en","primary_location":{"id":"doi:10.1186/2045-3701-1-11","doi":"https://doi.org/10.1186/2045-3701-1-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-3701-1-11","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/2045-3701-1-11","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/2045-3701-1-11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102173659","display_name":"Caixia Hou","orcid":"https://orcid.org/0000-0002-5335-8511","observed_orcids":["https://orcid.org/0000-0002-5335-8511"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caixia Hou","raw_affiliation_strings":["Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA. gmli@uky.edu","Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA. gmli@uky.edu","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083065407","display_name":"Tianyi Zhang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Tianyi Zhang","raw_affiliation_strings":["College of Life Sciences, Wuhan University, Wuhan, PR, China","Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","College of Life Sciences, Wuhan University, Wuhan, China","Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, PR, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lei Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Tian","raw_affiliation_strings":["Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053635111","display_name":"Jian Huang","orcid":"https://orcid.org/0009-0009-6448-4546","observed_orcids":["https://orcid.org/0009-0009-6448-4546"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Huang","raw_affiliation_strings":["College of Life Sciences, Wuhan University, Wuhan, PR, China","Wuhan Univ.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, PR, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Wuhan Univ.,","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114102770","display_name":"Liya Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liya Gu","raw_affiliation_strings":["Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102015607","display_name":"Guo\u2010Min Li","orcid":"https://orcid.org/0000-0002-9842-4578","observed_orcids":["https://orcid.org/0000-0002-9842-4578","https://orcid.org/0000-0001-7953-0220"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Guo-Min Li","raw_affiliation_strings":["College of Life Sciences, Wuhan University, Wuhan, PR, China","Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","College of Life Sciences, Wuhan University, Wuhan, China","Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, PR, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]},{"raw_affiliation_string":"College of Life Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Graduate Center for Toxicology and Markey Cancer Center, University of Kentucky College of Medicine, Lexington, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102015607"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656","https://openalex.org/I37461747"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":1.3909,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7975988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"11","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trinucleotide-repeat-expansion","display_name":"trinucleotide repeat expansion","score":0.921999990940094},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.8849999904632568},{"id":"https://openalex.org/keywords/genome-maintenance","display_name":"genome maintenance","score":0.8799999952316284},{"id":"https://openalex.org/keywords/trinucleotide-repeat-disorders","display_name":"trinucleotide repeat disorders","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5499961376190186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4773590564727783},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45684942603111267},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4153051972389221}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1186/2045-3701-1-11","doi":"https://doi.org/10.1186/2045-3701-1-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-3701-1-11","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/2045-3701-1-11","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},{"id":"pmid:21711735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21711735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & bioscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3125201","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3125201/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biosci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.291.1591","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.291.1591","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e0/b4/Cell_Biosci_2011_Mar_9_1_11.tar.gz","raw_type":"text"},{"id":"pmh:oai:uknowledge.uky.edu:toxicology_facpub-1010","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/toxicology_facpub/11","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicology and Cancer Biology Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:66ae9652fafb4eff96dac804d164387e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/66ae9652fafb4eff96dac804d164387e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell & Bioscience, Vol 1, Iss 1, p 11 (2011)","raw_type":"article"},{"id":"mag:2189190508","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1010&context=toxicology_facpub","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/2045-3701-1-11","doi":"https://doi.org/10.1186/2045-3701-1-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-3701-1-11","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/2045-3701-1-11","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5955015080","display_name":"DNA repair mechanisms in trinucleotide repeat instability","funder_award_id":"R01GM089684","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068305560.pdf","grobid_xml":"https://content.openalex.org/works/W2068305560.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W45339708","https://openalex.org/W1608453674","https://openalex.org/W1970814720","https://openalex.org/W1984865535","https://openalex.org/W1994843656","https://openalex.org/W2004640582","https://openalex.org/W2012071848","https://openalex.org/W2017237069","https://openalex.org/W2021091954","https://openalex.org/W2035037386","https://openalex.org/W2042160009","https://openalex.org/W2044088718","https://openalex.org/W2044954335","https://openalex.org/W2049601212","https://openalex.org/W2052085780","https://openalex.org/W2052893592","https://openalex.org/W2055305507","https://openalex.org/W2059340538","https://openalex.org/W2066436688","https://openalex.org/W2067818712","https://openalex.org/W2085617522","https://openalex.org/W2087505473","https://openalex.org/W2107849990","https://openalex.org/W2116394717","https://openalex.org/W2128552081","https://openalex.org/W2131173813","https://openalex.org/W2146335112","https://openalex.org/W2157462132"],"related_works":["https://openalex.org/W2189190508","https://openalex.org/W7098074749","https://openalex.org/W1992382559","https://openalex.org/W3172573988","https://openalex.org/W2066436688","https://openalex.org/W44208765","https://openalex.org/W3173695433","https://openalex.org/W1991918564","https://openalex.org/W2049812251","https://openalex.org/W2059340538"],"abstract_inverted_index":{"BACKGROUND:":[0],"During":[1],"DNA":[2,26,65,213],"replication":[3],"or":[4,24],"repair,":[5,70],"disease-associated":[6],"(CAG)n/(CTG)n":[7,33,40,80,92,109,205,222],"expansion":[8],"can":[9],"result":[10],"from":[11,42,148,163],"formation":[12],"of":[13,20,76,141],"hairpin":[14,34,93,122,223],"structures":[15],"in":[16,78,91,111,138,166,180,208,243,248],"the":[17,21,49,55,73,86,116,131,158,189,233],"repeat":[18,253],"tract":[19],"newly":[22,209],"synthesized":[23,210],"nicked":[25],"strand.":[27],"Recent":[28],"studies":[29],"identified":[30],"a":[31,229,238],"nick-directed":[32],"repair":[35,142],"(HPR)":[36],"system":[37],"that":[38,115,130,145,172,196],"removes":[39],"hairpins":[41,110,154,206],"human":[43,198],"cells":[44,199],"via":[45,155],"endonucleolytic":[46],"incisions.":[47],"Because":[48],"process":[50,108],"is":[51,89,135],"highly":[52],"similar":[53],"to":[54,107,188,203,232],"mechanism":[56],"by":[57,183,227,251],"which":[58],"XPG":[59,77,87,175,242,247],"and":[60,100,129,215,245],"XPF":[61],"endonucleases":[62],"remove":[63,152,204],"bulky":[64],"lesions":[66],"during":[67],"nucleotide":[68],"excision":[69],"we":[71],"assessed":[72],"potential":[74],"role":[75,240],"conducting":[79],"HPR.":[81,139],"RESULTS:":[82],"To":[83],"determine":[84],"if":[85],"endonuclease":[88],"involved":[90],"removal,":[94,224],"two":[95],"XPG-deficient":[96,150,181],"cell":[97,118,133],"lines":[98,151],"(GM16024":[99],"AG08802)":[101],"were":[102],"examined":[103],"for":[104,221,241],"their":[105],"ability":[106],"vitro.":[112],"We":[113,169],"demonstrated":[114],"GM16024":[117],"line":[119,134],"processes":[120],"all":[121],"substrates":[123],"as":[124,126],"efficiently":[125],"HeLa":[127,167],"cells,":[128],"AG08802":[132],"partially":[136],"defective":[137],"Analysis":[140],"intermediates":[143],"revealed":[144],"nuclear":[146],"extracts":[147,182],"both":[149],"CAG/CTG":[153],"incisions,":[156],"but":[157],"incision":[159,186,231],"products":[160],"are":[161],"distinct":[162],"those":[164],"generated":[165],"extracts.":[168],"also":[170],"show":[171],"purified":[173],"recombinant":[174],"protein":[176],"greatly":[177],"stimulates":[178,225],"HPR":[179,226],"promoting":[184],"an":[185],"5'":[187,230],"hairpin.":[190,234],"CONCLUSIONS:":[191],"Our":[192],"results":[193],"strongly":[194],"suggest":[195],"1)":[197],"possess":[200],"multiple":[201],"pathways":[202],"located":[207],"(or":[211],"nicked)":[212],"strand;":[214],"2)":[216],"XPG,":[217],"although":[218],"not":[219],"essential":[220],"facilitating":[228],"This":[235],"study":[236],"reveals":[237],"novel":[239],"genome-maintenance":[244],"implicates":[246],"diseases":[249],"caused":[250],"trinucleotide":[252],"expansion.":[254]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}