{"id":"https://openalex.org/W2068240232","doi":"https://doi.org/10.1083/jcb.136.3.669","title":"GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules","display_name":"GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules","publication_year":1997,"publication_date":"1997-02-10","ids":{"openalex":"https://openalex.org/W2068240232","doi":"https://doi.org/10.1083/jcb.136.3.669","mag":"2068240232","pmid":"https://pubmed.ncbi.nlm.nih.gov/9024696","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2134290"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.136.3.669","doi":"https://doi.org/10.1083/jcb.136.3.669","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.136.3.669","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2134290","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013204190","display_name":"Eunjoon Kim","orcid":"https://orcid.org/0000-0001-5518-6584","observed_orcids":["https://orcid.org/0000-0001-5518-6584"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunjoon Kim","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017425356","display_name":"Scott R. Naisbitt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Naisbitt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055749746","display_name":"Yi\u2010Ping Hsueh","orcid":"https://orcid.org/0000-0002-0866-6275","observed_orcids":["https://orcid.org/0000-0002-0866-6275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Ping Hsueh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109867746","display_name":"Anuradha Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuradha Rao","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; and *Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801","Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; and *Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I157725225","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038784186","display_name":"Adam Rothschild","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Rothschild","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063001738","display_name":"Ann Marie Craig","orcid":"https://orcid.org/0000-0002-8651-8200","observed_orcids":["https://orcid.org/0000-0002-8651-8200"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Marie Craig","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; and *Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801","Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; and *Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I157725225","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008631765","display_name":"Morgan Sheng","orcid":"https://orcid.org/0000-0002-8703-5366","observed_orcids":["https://orcid.org/0000-0002-8703-5366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morgan Sheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.9083,"has_fulltext":false,"cited_by_count":517,"citation_normalized_percentile":{"value":0.99608063,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"136","issue":"3","first_page":"669","last_page":"678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gkap","display_name":"GKAP","score":0.9860000014305115},{"id":"https://openalex.org/keywords/psd-95","display_name":"PSD-95","score":0.968999981880188},{"id":"https://openalex.org/keywords/synaptic-proteins","display_name":"synaptic proteins","score":0.6209999918937683},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ion-channel-clustering","display_name":"ion channel clustering","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sh3-domain","display_name":"SH3 domain","score":0.8999999761581421},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/maguk-proteins","display_name":"MAGUK proteins","score":0.8199999928474426},{"id":"https://openalex.org/keywords/p55","display_name":"p55","score":0.7149999737739563},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C172078151","wikidata":"https://www.wikidata.org/wiki/Q24784833","display_name":"Guanylate kinase","level":4,"score":0.9806389212608337},{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.9251879453659058},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.7182596921920776},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.5871790647506714},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5796911120414734},{"id":"https://openalex.org/C2780858604","wikidata":"https://www.wikidata.org/wiki/Q18033122","display_name":"CASK","level":2,"score":0.5005021095275879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42777812480926514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.327880322933197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30590927600860596},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.30449309945106506},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.28159233927726746},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2465980350971222},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2304023802280426},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.22200161218643188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10632529854774475},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074407","descriptor_name":"SAP90-PSD95 Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076122","descriptor_name":"Disks Large Homolog 4 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009703","descriptor_name":"Nucleoside-Phosphate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051528","descriptor_name":"Guanylate Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.136.3.669","doi":"https://doi.org/10.1083/jcb.136.3.669","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.136.3.669","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2134290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2134290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:9024696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9024696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.64","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.64","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c7/4e/J_Cell_Biol_1997_Feb_10_136(3)_669-678.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.322.3443","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.3443","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcb.rupress.org/content/136/3/669.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2134290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2134290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1432266639","display_name":"Subcellular Targeting of Neurotransmitter Receptors","funder_award_id":"R01NS033184","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1489215358","https://openalex.org/W1653383134","https://openalex.org/W1919311176","https://openalex.org/W1972414284","https://openalex.org/W1977394169","https://openalex.org/W1983102912","https://openalex.org/W1986435945","https://openalex.org/W1987313471","https://openalex.org/W1987700551","https://openalex.org/W1990907625","https://openalex.org/W2005289903","https://openalex.org/W2014730879","https://openalex.org/W2059124316","https://openalex.org/W2060061784","https://openalex.org/W2063759088","https://openalex.org/W2065033398","https://openalex.org/W2065989745","https://openalex.org/W2071169334","https://openalex.org/W2073360590","https://openalex.org/W2077706363","https://openalex.org/W2080694884","https://openalex.org/W2085252478","https://openalex.org/W2088028188","https://openalex.org/W2090948229","https://openalex.org/W2092442184","https://openalex.org/W2092734837","https://openalex.org/W2093573816","https://openalex.org/W2100350999","https://openalex.org/W2103093241","https://openalex.org/W2128208208","https://openalex.org/W2128703002","https://openalex.org/W2155298230","https://openalex.org/W2157195501"],"related_works":["https://openalex.org/W4299508284","https://openalex.org/W2142159344","https://openalex.org/W2018229588","https://openalex.org/W2056132493","https://openalex.org/W2077142887","https://openalex.org/W2089512569","https://openalex.org/W1964258885","https://openalex.org/W1984647008","https://openalex.org/W2024616932","https://openalex.org/W7098029236"],"abstract_inverted_index":{"The":[0],"molecular":[1],"mechanisms":[2],"underlying":[3],"the":[4,13,22,53,59,62,70,73,80,86,97,114,118,123,141,172,175,189],"organization":[5],"of":[6,21,25,55,61,72,89,99,117,122,140,167,191],"ion":[7,44],"channels":[8,45],"and":[9,48,79,133,146,152,156,199],"signaling":[10],"molecules":[11],"at":[12],"synaptic":[14,26,102],"junction":[15],"are":[16],"largely":[17],"unknown.":[18],"Recently,":[19],"members":[20,121],"PSD-95/SAP90":[23],"family":[24],"MAGUK":[27],"(membrane-associated":[28],"guanylate":[29,81,107,168],"kinase)":[30],"proteins":[31,194],"have":[32],"been":[33],"shown":[34],"to":[35,113,135],"interact,":[36],"via":[37],"their":[38,164],"NH2-terminal":[39,63],"PDZ":[40,64],"domains,":[41],"with":[42,148,154],"certain":[43],"(NMDA":[46],"receptors":[47,159],"K+":[49,157],"channels),":[50],"thereby":[51],"promoting":[52],"clustering":[54],"these":[56],"proteins.":[57],"Although":[58],"function":[60,71,190],"domains":[65],"is":[66],"relatively":[67],"well":[68],"characterized,":[69],"Src":[74],"homology":[75],"3":[76],"(SH3)":[77],"domain":[78,84,116,131,177],"kinase-like":[82],"(GK)":[83],"in":[85,150,160],"COOH-terminal":[87],"half":[88],"PSD-95":[90,125,149,155],"has":[91,186],"remained":[92],"obscure.":[93],"We":[94],"now":[95],"report":[96],"isolation":[98],"a":[100,129,137,181],"novel":[101],"protein,":[103,109],"termed":[104],"GKAP":[105,127,144],"for":[106,183,188],"kinase-associated":[108],"that":[110,174],"binds":[111],"directly":[112],"GK":[115,176],"four":[119],"known":[120],"mammalian":[124],"family.":[126],"shows":[128],"unique":[130],"structure":[132],"appears":[134],"be":[136],"major":[138],"constituent":[139],"postsynaptic":[142],"density.":[143],"colocalizes":[145],"coimmunoprecipitates":[147],"vivo,":[151],"coclusters":[153],"channels/NMDA":[158],"heterologous":[161],"cells.":[162],"Given":[163],"apparent":[165],"lack":[166],"kinase":[169],"enzymatic":[170],"activity,":[171],"fact":[173],"can":[178],"act":[179],"as":[180,196],"site":[182],"protein-protein":[184],"interaction":[185],"implications":[187],"diverse":[192],"GK-containing":[193],"(such":[195],"p55,":[197],"ZO-1,":[198],"LIN-2/CASK).":[200]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}