{"id":"https://openalex.org/W2068095708","doi":"https://doi.org/10.1016/j.addr.2011.06.014","title":"Molecular level insight into intra-solvent interaction effects on protein stability and aggregation","display_name":"Molecular level insight into intra-solvent interaction effects on protein stability and aggregation","publication_year":2011,"publication_date":"2011-07-07","ids":{"openalex":"https://openalex.org/W2068095708","doi":"https://doi.org/10.1016/j.addr.2011.06.014","mag":"2068095708","pmid":"https://pubmed.ncbi.nlm.nih.gov/21762737"},"language":"en","primary_location":{"id":"doi:10.1016/j.addr.2011.06.014","doi":"https://doi.org/10.1016/j.addr.2011.06.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.addr.2011.06.014","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053940473","display_name":"Diwakar Shukla","orcid":"https://orcid.org/0000-0003-4079-5381","observed_orcids":["https://orcid.org/0000-0003-4079-5381"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diwakar Shukla","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070810615","display_name":"Curtiss P. Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtiss P. Schneider","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000143645","display_name":"Bernhardt L. Trout","orcid":"https://orcid.org/0000-0003-1417-9470","observed_orcids":["https://orcid.org/0000-0003-1417-9470","https://orcid.org/0000-0002-9515-746X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bernhardt L. Trout","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000143645"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":5550,"currency":"USD","value_usd":5550},"apc_paid":null,"fwci":0.6487,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.52362269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"63","issue":"13","first_page":"1074","last_page":"1085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cosolutes","display_name":"cosolutes","score":0.7749999761581421},{"id":"https://openalex.org/keywords/therapeutic-proteins","display_name":"therapeutic proteins","score":0.7419999837875366},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.7275487780570984},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.5880664587020874},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4782799184322357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44426408410072327},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32689523696899414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17860499024391174},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1255185604095459},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.addr.2011.06.014","doi":"https://doi.org/10.1016/j.addr.2011.06.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.addr.2011.06.014","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},{"id":"pmid:21762737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21762737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced drug delivery reviews","raw_type":"Journal Article"},{"id":"mag:2189479800","doi":null,"is_oa":false,"landing_page_url":"http://wolfson.huji.ac.il/purification/Course92632_2014/Aggregation/Shukla2011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":141,"referenced_works":["https://openalex.org/W230984257","https://openalex.org/W892297446","https://openalex.org/W1022983837","https://openalex.org/W1529550306","https://openalex.org/W1532551781","https://openalex.org/W1533503876","https://openalex.org/W1562907760","https://openalex.org/W1576271719","https://openalex.org/W1581858536","https://openalex.org/W1605936672","https://openalex.org/W1608385296","https://openalex.org/W1911074457","https://openalex.org/W1941688331","https://openalex.org/W1967820830","https://openalex.org/W1968324550","https://openalex.org/W1970898345","https://openalex.org/W1971691313","https://openalex.org/W1971847312","https://openalex.org/W1972282241","https://openalex.org/W1972325947","https://openalex.org/W1975727760","https://openalex.org/W1977420392","https://openalex.org/W1978195452","https://openalex.org/W1980375852","https://openalex.org/W1980576769","https://openalex.org/W1982709972","https://openalex.org/W1982762997","https://openalex.org/W1983970124","https://openalex.org/W1984903816","https://openalex.org/W1985015433","https://openalex.org/W1985181309","https://openalex.org/W1985941856","https://openalex.org/W1986115510","https://openalex.org/W1987052717","https://openalex.org/W1989419578","https://openalex.org/W1991163974","https://openalex.org/W1996035003","https://openalex.org/W1996229842","https://openalex.org/W1997215775","https://openalex.org/W1997723318","https://openalex.org/W2000943591","https://openalex.org/W2001129137","https://openalex.org/W2001552830","https://openalex.org/W2002608130","https://openalex.org/W2002846749","https://openalex.org/W2003220369","https://openalex.org/W2005812776","https://openalex.org/W2006211137","https://openalex.org/W2007584726","https://openalex.org/W2007760903","https://openalex.org/W2009136136","https://openalex.org/W2009698511","https://openalex.org/W2010216657","https://openalex.org/W2011384774","https://openalex.org/W2011881868","https://openalex.org/W2012434595","https://openalex.org/W2012561030","https://openalex.org/W2017643816","https://openalex.org/W2018401285","https://openalex.org/W2018844143","https://openalex.org/W2019210215","https://openalex.org/W2019456940","https://openalex.org/W2021044472","https://openalex.org/W2024683933","https://openalex.org/W2027133303","https://openalex.org/W2029779460","https://openalex.org/W2029802808","https://openalex.org/W2030450209","https://openalex.org/W2031672665","https://openalex.org/W2032406779","https://openalex.org/W2032895706","https://openalex.org/W2035651421","https://openalex.org/W2037580706","https://openalex.org/W2037958927","https://openalex.org/W2038634233","https://openalex.org/W2041657602","https://openalex.org/W2043142471","https://openalex.org/W2045458270","https://openalex.org/W2045589999","https://openalex.org/W2045933761","https://openalex.org/W2053850848","https://openalex.org/W2054342626","https://openalex.org/W2058027175","https://openalex.org/W2061588414","https://openalex.org/W2062028366","https://openalex.org/W2065809333","https://openalex.org/W2066018632","https://openalex.org/W2069974072","https://openalex.org/W2071095038","https://openalex.org/W2071399838","https://openalex.org/W2072022372","https://openalex.org/W2073948759","https://openalex.org/W2074244507","https://openalex.org/W2077118080","https://openalex.org/W2077919900","https://openalex.org/W2079151610","https://openalex.org/W2080538147","https://openalex.org/W2081306620","https://openalex.org/W2081307882","https://openalex.org/W2081640562","https://openalex.org/W2084076880","https://openalex.org/W2084468801","https://openalex.org/W2085123622","https://openalex.org/W2086292995","https://openalex.org/W2086981775","https://openalex.org/W2088869535","https://openalex.org/W2090656725","https://openalex.org/W2091404954","https://openalex.org/W2091760778","https://openalex.org/W2092761280","https://openalex.org/W2093577194","https://openalex.org/W2098205678","https://openalex.org/W2103208396","https://openalex.org/W2106043217","https://openalex.org/W2106275356","https://openalex.org/W2109811866","https://openalex.org/W2112553122","https://openalex.org/W2118864235","https://openalex.org/W2122837549","https://openalex.org/W2123419409","https://openalex.org/W2129919697","https://openalex.org/W2135964386","https://openalex.org/W2136310012","https://openalex.org/W2137447171","https://openalex.org/W2140740447","https://openalex.org/W2144063308","https://openalex.org/W2144662157","https://openalex.org/W2151548440","https://openalex.org/W2154280514","https://openalex.org/W2157305461","https://openalex.org/W2161596727","https://openalex.org/W2164915841","https://openalex.org/W2218139562","https://openalex.org/W2313609035","https://openalex.org/W2314752699","https://openalex.org/W2315765305","https://openalex.org/W2324160417","https://openalex.org/W2328950089","https://openalex.org/W2329952272","https://openalex.org/W2593211299","https://openalex.org/W4238520503"],"related_works":["https://openalex.org/W2189479800","https://openalex.org/W7095919932","https://openalex.org/W1598349654","https://openalex.org/W7098632620","https://openalex.org/W2131678310","https://openalex.org/W7038426285","https://openalex.org/W1557984653","https://openalex.org/W1532551781","https://openalex.org/W2161090350","https://openalex.org/W3011087670"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}