{"id":"https://openalex.org/W2068050243","doi":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","title":"Direct Evidence for Homologous Recombination in Mussel (Mytilus galloprovincialis) Mitochondrial DNA","display_name":"Direct Evidence for Homologous Recombination in Mussel (Mytilus galloprovincialis) Mitochondrial DNA","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2068050243","doi":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","mag":"2068050243","pmid":"https://pubmed.ncbi.nlm.nih.gov/11420358"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.molbev.a003904","doi":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","pdf_url":"https://academic.oup.com/mbe/article-pdf/18/7/1168/23449332/mbev_18_07_1168.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mbe/article-pdf/18/7/1168/23449332/mbev_18_07_1168.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001529713","display_name":"Emmanuel D. Ladoukakis","orcid":"https://orcid.org/0000-0002-1123-5396","observed_orcids":["https://orcid.org/0000-0002-1123-5396"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Emmanuel D. Ladoukakis","raw_affiliation_strings":["Department of Biology, University of Crete, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Crete, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113698605","display_name":"E. Zouros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Eleftherios Zouros","raw_affiliation_strings":["Department of Biology, University of Crete, Crete, Greece; and \u2020Institute of Marine Biology of Crete, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Crete, Crete, Greece; and \u2020Institute of Marine Biology of Crete, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113698605"],"corresponding_institution_ids":["https://openalex.org/I142617266"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":3.7507,"has_fulltext":true,"cited_by_count":208,"citation_normalized_percentile":{"value":0.94598331,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"18","issue":"7","first_page":"1168","last_page":"1175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.40630000829696655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.40630000829696655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.10930000245571136,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0908999964594841,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mytilus-galloprovincialis","display_name":"Mytilus galloprovincialis","score":0.996999979019165},{"id":"https://openalex.org/keywords/mussels","display_name":"mussels","score":0.7829999923706055},{"id":"https://openalex.org/keywords/heteroplasmy","display_name":"heteroplasmy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mtdna-repair","display_name":"mtDNA repair","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.4050000011920929},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6930000185966492},{"id":"https://openalex.org/keywords/biparental-inheritance","display_name":"biparental inheritance","score":0.824999988079071},{"id":"https://openalex.org/keywords/maternal-inheritance","display_name":"maternal inheritance","score":0.5460000038146973},{"id":"https://openalex.org/keywords/mitochondrial-genome-evolution","display_name":"mitochondrial genome evolution","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C181561989","wikidata":"https://www.wikidata.org/wiki/Q2581905","display_name":"Heteroplasmy","level":4,"score":0.9225642681121826},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.9057296514511108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9054361581802368},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7153633832931519},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6401931047439575},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.5060521960258484},{"id":"https://openalex.org/C50919411","wikidata":"https://www.wikidata.org/wiki/Q5334294","display_name":"Ectopic recombination","level":5,"score":0.47551992535591125},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.46806326508522034},{"id":"https://openalex.org/C151994961","wikidata":"https://www.wikidata.org/wiki/Q715263","display_name":"Human mitochondrial genetics","level":4,"score":0.441061407327652},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4120522737503052},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.40130555629730225},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2838219106197357},{"id":"https://openalex.org/C101434241","wikidata":"https://www.wikidata.org/wiki/Q211675","display_name":"Genetic recombination","level":4,"score":0.2814328372478485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1573658585548401}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049872","descriptor_name":"Bivalvia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.molbev.a003904","doi":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","pdf_url":"https://academic.oup.com/mbe/article-pdf/18/7/1168/23449332/mbev_18_07_1168.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:11420358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11420358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/oxfordjournals.molbev.a003904","doi":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","is_oa":true,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.molbev.a003904","pdf_url":"https://academic.oup.com/mbe/article-pdf/18/7/1168/23449332/mbev_18_07_1168.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068050243.pdf","grobid_xml":"https://content.openalex.org/works/W2068050243.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W129160841","https://openalex.org/W195126743","https://openalex.org/W1526745856","https://openalex.org/W1548557487","https://openalex.org/W1550571154","https://openalex.org/W1561497451","https://openalex.org/W1562403836","https://openalex.org/W1565786643","https://openalex.org/W1765516395","https://openalex.org/W1832451639","https://openalex.org/W1880845650","https://openalex.org/W1901948856","https://openalex.org/W1916532806","https://openalex.org/W1917558595","https://openalex.org/W1963715201","https://openalex.org/W1965357743","https://openalex.org/W1966276039","https://openalex.org/W1966461639","https://openalex.org/W1967205646","https://openalex.org/W1968967926","https://openalex.org/W1981161568","https://openalex.org/W1983918667","https://openalex.org/W1992900246","https://openalex.org/W2008149066","https://openalex.org/W2010167976","https://openalex.org/W2010211127","https://openalex.org/W2010431679","https://openalex.org/W2014972109","https://openalex.org/W2016544300","https://openalex.org/W2031734964","https://openalex.org/W2047560329","https://openalex.org/W2055129183","https://openalex.org/W2056464864","https://openalex.org/W2062868575","https://openalex.org/W2063390296","https://openalex.org/W2064553943","https://openalex.org/W2073692724","https://openalex.org/W2077414996","https://openalex.org/W2088036960","https://openalex.org/W2090369699","https://openalex.org/W2097382368","https://openalex.org/W2105238344","https://openalex.org/W2114968751","https://openalex.org/W2118094114","https://openalex.org/W2120192572","https://openalex.org/W2129452041","https://openalex.org/W2133279612","https://openalex.org/W2136655076","https://openalex.org/W2136719196","https://openalex.org/W2148462579","https://openalex.org/W2148505120","https://openalex.org/W2152321288","https://openalex.org/W2157626900","https://openalex.org/W2164518857","https://openalex.org/W2168830043","https://openalex.org/W2169105511","https://openalex.org/W2171596181","https://openalex.org/W2320133151","https://openalex.org/W2332939960","https://openalex.org/W2423279358","https://openalex.org/W2770504902","https://openalex.org/W4238474627","https://openalex.org/W4248047118"],"related_works":["https://openalex.org/W2037306184","https://openalex.org/W7098148023","https://openalex.org/W2082979041","https://openalex.org/W2166288888","https://openalex.org/W2104975847","https://openalex.org/W2115854588","https://openalex.org/W1501727782","https://openalex.org/W7099768398","https://openalex.org/W2100928172","https://openalex.org/W2077407914"],"abstract_inverted_index":{"The":[0],"assumption":[1],"that":[2,112,128,136],"animal":[3,129,165],"mitochondrial":[4,35,156],"DNA":[5],"(mtDNA)":[6],"does":[7],"not":[8],"undergo":[9],"homologous":[10,87,123],"recombination":[11,52,89],"is":[12,94],"based":[13],"on":[14,24,40,56,148],"indirect":[15],"evidence,":[16],"yet":[17],"it":[18],"has":[19],"had":[20],"an":[21],"important":[22],"influence":[23],"our":[25],"understanding":[26],"of":[27,59,61,67,105,122,151,154],"mtDNA":[28,55,68,88,106,130,170],"repair":[29],"and":[30,37,39,64,135],"mutation":[31],"accumulation":[32],"(and":[33],"thus":[34],"disease":[36],"aging)":[38],"biohistorical":[41],"inferences":[42],"made":[43],"from":[44,164],"population":[45],"data.":[46],"Recently,":[47],"several":[48],"studies":[49],"have":[50,75],"suggested":[51],"in":[53,70,90,97],"primate":[54],"the":[57,95,110,116,120,137,149,155],"basis":[58],"patterns":[60],"frequency":[62,150],"distribution":[63],"linkage":[65],"associations":[66],"mutations":[69],"human":[71],"populations,":[72],"but":[73],"others":[74],"failed":[76],"to":[77,139],"produce":[78],"similar":[79],"evidence.":[80],"Here,":[81],"we":[82],"provide":[83],"direct":[84],"evidence":[85,163],"for":[86,119],"mussels,":[91],"where":[92],"heteroplasmy":[93],"rule":[96],"males.":[98],"Our":[99],"results":[100],"indicate":[101],"a":[102],"high":[103],"rate":[104],"recombination.":[107],"Coupled":[108],"with":[109,167],"observation":[111],"mammalian":[113],"mitochondria":[114],"contain":[115],"enzymes":[117],"needed":[118],"catalysis":[121],"recombination,":[124],"these":[125],"findings":[126],"suggest":[127],"molecules":[131],"may":[132,145],"recombine":[133],"regularly":[134],"extent":[138],"which":[140],"this":[141],"generates":[142],"new":[143],"haplotypes":[144],"depend":[146],"only":[147],"biparental":[152],"inheritance":[153],"genome.":[157],"This":[158],"generalization":[159],"must,":[160],"however,":[161],"await":[162],"species":[166],"typical":[168],"maternal":[169],"inheritance.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}