{"id":"https://openalex.org/W2068009304","doi":"https://doi.org/10.1177/1074248408321461","title":"Efficacy of Atorvastatin for Achieving Cholesterol Targets After LDL-Cholesterol Based Dose Selection in Patients With Type 2 Diabetes","display_name":"Efficacy of Atorvastatin for Achieving Cholesterol Targets After LDL-Cholesterol Based Dose Selection in Patients With Type 2 Diabetes","publication_year":2008,"publication_date":"2008-05-06","ids":{"openalex":"https://openalex.org/W2068009304","doi":"https://doi.org/10.1177/1074248408321461","mag":"2068009304","pmid":"https://pubmed.ncbi.nlm.nih.gov/18635754"},"language":"en","primary_location":{"id":"doi:10.1177/1074248408321461","doi":"https://doi.org/10.1177/1074248408321461","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1074248408321461","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1074248408321461?download=true","source":{"id":"https://openalex.org/S130832228","display_name":"Journal of Cardiovascular Pharmacology and Therapeutics","issn_l":"1074-2484","issn":["1074-2484","1940-4034"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/1074248408321461?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110082994","display_name":"Juan Carlos Ferrer-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127649","display_name":"Hospital General Universitario De Valencia","ror":"https://ror.org/03sz8rb35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127649"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan Carlos Ferrer-Garc\u00eda","raw_affiliation_strings":["Division of Diabetes, Consortium University General Hospital of Valencia,","Division of Diabetes, Consortium University General Hospital of Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Consortium University General Hospital of Valencia,","institution_ids":["https://openalex.org/I4210127649"]},{"raw_affiliation_string":"Division of Diabetes, Consortium University General Hospital of Valencia, Spain","institution_ids":["https://openalex.org/I4210127649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086007298","display_name":"Eva Sanchez-Ballester","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Sanchez-Ballester","raw_affiliation_strings":["Department of Internal Medicine, Consortium University General Hospital of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Consortium University General Hospital of Valencia, Valencia, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053656945","display_name":"Raquel Albalat-Galera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127649","display_name":"Hospital General Universitario De Valencia","ror":"https://ror.org/03sz8rb35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127649"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Albalat-Galera","raw_affiliation_strings":["Division of Diabetes, Consortium University General Hospital of Valencia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Consortium University General Hospital of Valencia","institution_ids":["https://openalex.org/I4210127649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061207323","display_name":"Miguel Berzosa S\u00e1nchez","orcid":"https://orcid.org/0000-0002-2993-0901","observed_orcids":["https://orcid.org/0000-0002-2993-0901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Berzosa-Sanchez","raw_affiliation_strings":["Department of Internal Medicine, Consortium University General Hospital of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Consortium University General Hospital of Valencia, Valencia, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038486503","display_name":"Agust\u00edn Herrera-Ballester","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agust\u00edn Herrera-Ballester","raw_affiliation_strings":["Department of Internal Medicine, Consortium University General Hospital of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Consortium University General Hospital of Valencia, Valencia, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110082994"],"corresponding_institution_ids":["https://openalex.org/I4210127649"],"apc_list":{"value":1325,"currency":"USD","value_usd":1325},"apc_paid":null,"fwci":0.2355,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66290351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"3","first_page":"183","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7139999866485596},{"id":"https://openalex.org/keywords/dose-selection","display_name":"dose selection","score":0.5299999713897705},{"id":"https://openalex.org/keywords/ldl-cholesterol-targets","display_name":"LDL cholesterol targets","score":0.4480000138282776},{"id":"https://openalex.org/keywords/statin-naive-patients","display_name":"statin-naive patients","score":0.8109999895095825},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cholesterol-lowering","display_name":"cholesterol lowering","score":0.421999990940094},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9070000052452087},{"id":"https://openalex.org/keywords/statin-tolerability","display_name":"statin tolerability","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.984054684638977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.915125846862793},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6810250878334045},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.6519293785095215},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6204356551170349},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.6128591895103455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5384348034858704},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5261378288269043},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.442180335521698},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4292576313018799},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40725260972976685},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4070817828178406},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33691948652267456},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27440837025642395}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/1074248408321461","doi":"https://doi.org/10.1177/1074248408321461","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1074248408321461","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1074248408321461?download=true","source":{"id":"https://openalex.org/S130832228","display_name":"Journal of Cardiovascular Pharmacology and Therapeutics","issn_l":"1074-2484","issn":["1074-2484","1940-4034"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:18635754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18635754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology and therapeutics","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.998.6518","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.998.6518","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cpt.sagepub.com/content/13/3/183.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1177/1074248408321461","doi":"https://doi.org/10.1177/1074248408321461","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1074248408321461","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1074248408321461?download=true","source":{"id":"https://openalex.org/S130832228","display_name":"Journal of Cardiovascular Pharmacology and Therapeutics","issn_l":"1074-2484","issn":["1074-2484","1940-4034"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068009304.pdf","grobid_xml":"https://content.openalex.org/works/W2068009304.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W207692563","https://openalex.org/W1445342927","https://openalex.org/W1886627904","https://openalex.org/W1986900160","https://openalex.org/W2014759828","https://openalex.org/W2019473642","https://openalex.org/W2026814068","https://openalex.org/W2031185570","https://openalex.org/W2031831221","https://openalex.org/W2043253248","https://openalex.org/W2049725071","https://openalex.org/W2053365438","https://openalex.org/W2053390057","https://openalex.org/W2057542355","https://openalex.org/W2057674977","https://openalex.org/W2102602093","https://openalex.org/W2106322128","https://openalex.org/W2106536809","https://openalex.org/W2107295258","https://openalex.org/W2111065997","https://openalex.org/W2116404316","https://openalex.org/W2121971971","https://openalex.org/W2149823862","https://openalex.org/W2154434917","https://openalex.org/W2154704322","https://openalex.org/W2565229519","https://openalex.org/W4230870013","https://openalex.org/W4232541108"],"related_works":["https://openalex.org/W2374471308","https://openalex.org/W7099378695","https://openalex.org/W2395631627","https://openalex.org/W2106322128","https://openalex.org/W2139827795","https://openalex.org/W1824295310","https://openalex.org/W7096525983","https://openalex.org/W2399984624","https://openalex.org/W1986986886","https://openalex.org/W7098440558"],"abstract_inverted_index":{"We":[0],"analyzed":[1],"the":[2,59,64,81,86,90,93,118,147,170],"feasibility":[3],"of":[4,14,47,61,70,85,110,120,150,163],"an":[5],"intensive":[6],"lipid-lowering":[7],"strategy":[8],"based":[9,49],"on":[10,50],"a":[11,44,160],"starting":[12,148],"dose":[13,149],"atorvastatin":[15,48,78,151],"according":[16,152],"to":[17,42,153,168],"baseline":[18,154],"and":[19,99,105,129,135,138,155],"target":[20,95,156,171],"low-density":[21],"lipoprotein":[22,126],"cholesterol":[23,127],"(LDL-C)":[24],"level":[25],"(<2.6":[26],"mmol/L)":[27],"in":[28,76],"202":[29],"statin-na\u00efve":[30],"patients":[31,62,88,167],"with":[32,101],"type":[33,164],"2":[34,165],"diabetes":[35],"within":[36,172],"24":[37,68,173],"weeks.":[38,174],"They":[39],"were":[40,74,142],"assigned":[41],"receive":[43],"daily":[45],"dosage":[46],"their":[51],"initial":[52],"LDL-C":[53,65,94,114,157],"levels.":[54],"The":[55],"primary":[56],"endpoint":[57],"was":[58],"proportion":[60,162],"achieving":[63],"goal":[66],"after":[67],"weeks":[69],"treatment.":[71],"No":[72],"changes":[73],"made":[75],"prescribed":[77],"dosage.":[79],"At":[80],"study":[82],"end,":[83],"66.5%":[84],"188":[87],"completing":[89],"trial":[91],"reached":[92,113],"(75%,":[96],"67%,":[97],"58%":[98],"59%":[100],"10,":[102],"20,":[103],"40":[104],"80":[106],"mg":[107],"per":[108],"day":[109],"atorvastatin,":[111],"respectively)":[112],"target.":[115],"Atorvastatin":[116],"reduced":[117],"levels":[119],"total":[121],"cholesterol,":[122],"LDL-C,":[123],"high":[124,161],"density":[125],"(HDL-C)":[128],"triglycerides":[130],"by":[131],"29%,":[132],"35%,":[133],"3%":[134],"22%,":[136],"respectively,":[137],"all":[139],"statin":[140],"doses":[141],"well":[143],"tolerated.":[144],"Thus,":[145],"individualizing":[146],"levels,":[158],"allowed":[159],"diabetic":[166],"achieve":[169]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}