{"id":"https://openalex.org/W2067925299","doi":"https://doi.org/10.1158/1535-7163.targ-13-b132","title":"Abstract B132: Next generation sequencing yields promising targets in advanced cholangiocarcinoma (CCA).","display_name":"Abstract B132: Next generation sequencing yields promising targets in advanced cholangiocarcinoma (CCA).","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2067925299","doi":"https://doi.org/10.1158/1535-7163.targ-13-b132","mag":"2067925299"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-13-b132","doi":"https://doi.org/10.1158/1535-7163.targ-13-b132","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-b132","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060960652","display_name":"Chaitanya R. Churi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaitanya R. Churi","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102003809","display_name":"Asif Rashid","orcid":"https://orcid.org/0000-0001-8463-7321","observed_orcids":["https://orcid.org/0000-0001-8463-7321","https://orcid.org/0000-0002-2922-8768"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asif Rashid","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012936802","display_name":"Rachna T. Shroff","orcid":"https://orcid.org/0000-0003-0066-2672","observed_orcids":["https://orcid.org/0000-0003-0066-2672"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachna Shroff","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091703176","display_name":"Lopa Mishra","orcid":"https://orcid.org/0000-0002-6850-0808","observed_orcids":["https://orcid.org/0000-0002-6850-0808"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lopa Mishra","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078205317","display_name":"Mingxin Zuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingxin Zuo","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034799194","display_name":"Ahmed S. Kaseb","orcid":"https://orcid.org/0000-0002-2579-966X","observed_orcids":["https://orcid.org/0000-0002-2579-966X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Kaseb","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071800834","display_name":"Filip Jank\u00fa","orcid":"https://orcid.org/0000-0002-8123-4065","observed_orcids":["https://orcid.org/0000-0002-8123-4065"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filip Janku","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071693096","display_name":"Thomas A. Aloia","orcid":"https://orcid.org/0000-0001-8581-4529","observed_orcids":["https://orcid.org/0000-0001-8581-4529"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Aloia","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109958598","display_name":"J.N. Vauthey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Nicholas Vauthey","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042809748","display_name":"Steven A. Curley","orcid":"https://orcid.org/0000-0001-9533-2769","observed_orcids":["https://orcid.org/0000-0001-9533-2769"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Curley","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088809839","display_name":"Siraj Mahamed Ali","orcid":"https://orcid.org/0000-0001-7477-4023","observed_orcids":["https://orcid.org/0000-0001-7477-4023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siraj Ali","raw_affiliation_strings":["2Foundation Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061636658","display_name":"Gary A. Palmer","orcid":"https://orcid.org/0000-0002-0173-1329","observed_orcids":["https://orcid.org/0000-0002-0173-1329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Palmer","raw_affiliation_strings":["2Foundation Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Foundation Medicine, Boston, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054771911","display_name":"Milind M. Javle","orcid":"https://orcid.org/0000-0001-9158-0941","observed_orcids":["https://orcid.org/0000-0001-9158-0941"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milind Javle","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"11_Supplement","first_page":"B132","last_page":"B132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.878000020980835},{"id":"https://openalex.org/keywords/genomic-variation","display_name":"genomic variation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.9470000267028809},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6710000038146973},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.4569999873638153},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.6000000238418579},{"id":"https://openalex.org/keywords/arid1a","display_name":"ARID1A","score":0.6769999861717224},{"id":"https://openalex.org/keywords/pbrm1","display_name":"PBRM1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/bap1","display_name":"BAP1","score":0.906000018119812},{"id":"https://openalex.org/keywords/fbxw7","display_name":"FBXW7","score":0.8309999704360962},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9459999799728394},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-cycle-pathway","display_name":"cell cycle pathway","score":0.5509999990463257},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.4830000102519989},{"id":"https://openalex.org/keywords/mek","display_name":"MEK","score":0.8050000071525574},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.892433762550354},{"id":"https://openalex.org/C2781273526","wikidata":"https://www.wikidata.org/wiki/Q18032797","display_name":"ARID1A","level":4,"score":0.6598344445228577},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5469090342521667},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5389573574066162},{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.5046006441116333},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49933338165283203},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.47601065039634705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45001381635665894},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.44210225343704224},{"id":"https://openalex.org/C2777983448","wikidata":"https://www.wikidata.org/wiki/Q2745322","display_name":"STK11","level":5,"score":0.43497663736343384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.398642361164093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3881968855857849},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38476404547691345},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3639272153377533},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.31308436393737793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3036779761314392},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.22028493881225586}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-13-b132","doi":"https://doi.org/10.1158/1535-7163.targ-13-b132","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-b132","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2589898297","https://openalex.org/W1974564771","https://openalex.org/W4379334098","https://openalex.org/W7095705743","https://openalex.org/W3135403528","https://openalex.org/W4376618338","https://openalex.org/W2889588377","https://openalex.org/W4306367239","https://openalex.org/W3111794783","https://openalex.org/W4379332940"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2],"incidence":[3],"of":[4,12,42,45,62,76,97,218,242,252,331],"CCA":[5,46,246,274],"is":[6,15],"rising":[7],"and":[8,111,140,148,197,232,248,338],"the":[9,79,238,250,332],"clinical":[10],"efficacy":[11],"systemic":[13],"therapy":[14],"suboptimal.":[16],"Next":[17,318],"generation":[18,319],"sequencing":[19,56,320],"(NGS)":[20],"technology":[21],"offers":[22],"potential":[23],"for":[24,59,257,273],"targeted":[25,259],"therapeutics":[26],"against":[27],"genetically":[28],"heterogenous":[29],"solid":[30],"tumors":[31,116],"including":[32],"cholangiocarcinoma":[33,326],"(CCA).":[34,327],"Methods:":[35],"DNA":[36,55,198],"was":[37,57,153,171],"extracted":[38],"from":[39,69,90,204],"biopsy":[40],"specimens":[41],"56":[43,91],"patients":[44,167,247,275],"seen":[47],"at":[48],"MD":[49],"Anderson":[50],"Cancer":[51,284,339,350],"Center":[52],"Houston,":[53],"TX.":[54],"performed":[58],"3,769":[60],"exons":[61],"236":[63],"cancer-related":[64],"genes":[65,71],"plus":[66],"47":[67],"introns":[68],"19":[70],"to":[72,226,269],"an":[73,95],"average":[74,96],"depth":[75],"1000X":[77],"using":[78],"Illumina":[80],"HiSeq":[81],"2000":[82],"platform.Results:":[83],"162":[84],"genomic":[85],"variations":[86],"(GV)":[87],"were":[88,104,123,214],"identified":[89,103],"patient":[92],"samples":[93],"with":[94,155,168],"2.89":[98],"GVs/patient":[99],"(range":[100],"0-10).":[101],"GVs":[102,122,144,213,253],"mutations":[105,147],"(72%),":[106],"amplifications":[107],"(17%),":[108],"loss/deletions":[109],"(7%)":[110],"others":[112],"(4%).":[113],"6":[114],"(11%)":[115],"showed":[117],"no":[118],"GVs.":[119],"Most":[120],"frequent":[121],"TP53":[124],"(35%),":[125],"KRAS":[126,151,169,178],"(31%),":[127],"ARID1A":[128],"(16%),":[129],"PBRM1":[130],"(11%),":[131],"BAP1":[132],"(9%),":[133,135,137],"ERBB2":[134,143],"FBXW7":[136],"SMAD4":[138],"(9%)":[139],"IDH1":[141],"(7%).":[142],"included":[145],"4":[146],"1":[149],"amplification.":[150],"mutation":[152,170],"associated":[154],"a":[156,267],"statistically":[157],"significant":[158],"reduction":[159],"in":[160,166,177,191,209,216,324],"overall":[161],"survival":[162],"(OS).":[163],"Mean":[164],"OS":[165],"32":[172],"weeks":[173,176],"vs.":[174],"63":[175],"wt":[179],"(t":[180],"=":[181,184],"-2.126,":[182],"p":[183],"0.039).":[185],"Ingenuity":[186],"Pathway":[187],"Analysis":[188],"indicated":[189],"disruption":[190],"cell":[192],"cycle,":[193],"proliferation,":[194],"development,":[195],"death":[196],"repair":[199],"pathways.":[200],"Targetable":[201,212],"signaling":[202],"pathways":[203],"this":[205],"study":[206],"are":[207,221,237,255],"described":[208],"Table":[210],"1.":[211],"noted":[215],"59%":[217],"patients.":[219],"These":[220,235,261],"potentially":[222],"targetable":[223],"by":[224],"inhibitors":[225],"ERBB2,":[227],"FGF,":[228],"mTOR,":[229],"MEK,":[230],"BRAF":[231],"PARP-1.":[233],"Conclusion:":[234],"data":[236],"single":[239],"largest":[240],"compilation":[241],"NGS":[243],"analysis":[244],"on":[245,277],"demonstrate":[249],"range":[251],"that":[254],"eligible":[256],"investigational":[258],"therapies.":[260],"results":[262],"can":[263],"be":[264],"used":[265],"as":[266],"basis":[268],"develop":[270],"personalized":[271],"treatments":[272],"based":[276],"individual":[278],"genetic":[279],"profiles.":[280],"Citation":[281,288],"Information:":[282],"Mol":[283,349],"Ther":[285,351],"2013;12(11":[286,352],"Suppl):B132.":[287],"Format:":[289],"Chaitanya":[290],"R.":[291],"Churi,":[292],"Asif":[293],"Rashid,":[294],"Rachna":[295],"Shroff,":[296],"Lopa":[297],"Mishra,":[298],"Mingxin":[299],"Zuo,":[300],"Ahmed":[301],"Kaseb,":[302],"Filip":[303],"Janku,":[304],"Thomas":[305],"A.":[306],"Aloia,":[307],"Jean-Nicholas":[308],"Vauthey,":[309],"Steven":[310],"Curley,":[311],"Siraj":[312],"Ali,":[313],"Gary":[314],"Palmer,":[315],"Milind":[316],"Javle.":[317],"yields":[321],"promising":[322],"targets":[323],"advanced":[325],"[abstract].":[328],"In:":[329],"Proceedings":[330],"AACR-NCI-EORTC":[333],"International":[334],"Conference:":[335],"Molecular":[336],"Targets":[337],"Therapeutics;":[340],"2013":[341],"Oct":[342],"19-23;":[343],"Boston,":[344],"MA.":[345],"Philadelphia":[346],"(PA):":[347],"AACR;":[348],"Suppl):Abstract":[353],"nr":[354],"B132.":[355]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
