{"id":"https://openalex.org/W2067782874","doi":"https://doi.org/10.1042/bj20091448","title":"Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA","display_name":"Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA","publication_year":2009,"publication_date":"2009-12-23","ids":{"openalex":"https://openalex.org/W2067782874","doi":"https://doi.org/10.1042/bj20091448","mag":"2067782874","pmid":"https://pubmed.ncbi.nlm.nih.gov/20015050"},"language":"en","primary_location":{"id":"doi:10.1042/bj20091448","doi":"https://doi.org/10.1042/bj20091448","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20091448","pdf_url":"https://portlandpress.com/biochemj/article-pdf/426/2/219/733351/bj4260219.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://portlandpress.com/biochemj/article-pdf/426/2/219/733351/bj4260219.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109931291","display_name":"Kate A. Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate\u00a0A. Owen","raw_affiliation_strings":["Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024076712","display_name":"Deyi Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Deyi Qiu","raw_affiliation_strings":["Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034960118","display_name":"Juliano Vilela Alves","orcid":"https://orcid.org/0000-0002-6555-5547","observed_orcids":["https://orcid.org/0000-0002-6555-5547"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliano Alves","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109451550","display_name":"Andrew M. Schumacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew\u00a0M. Schumacher","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004382493","display_name":"Lynette M. Kilpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lynette\u00a0M. Kilpatrick","raw_affiliation_strings":["Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361921","display_name":"\u00adJun Li\u00ad","orcid":"https://orcid.org/0000-0002-7236-8088","observed_orcids":["https://orcid.org/0000-0002-7236-8088"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer\u00a0L. Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer\u00a0L. Harris","raw_affiliation_strings":["Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, U.S.A","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110095697","display_name":"Vincent Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Vincent Ellis","raw_affiliation_strings":["Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U.K","institution_ids":["https://openalex.org/I1118541"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024076712","https://openalex.org/A5110095697"],"corresponding_institution_ids":["https://openalex.org/I1118541"],"apc_list":null,"apc_paid":null,"fwci":2.6757,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.90542715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"426","issue":"2","first_page":"219","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/matriptase","display_name":"matriptase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hepsin","display_name":"hepsin","score":1.0},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/type-ii-transmembrane-serine-protease","display_name":"type II transmembrane serine protease","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pericellular-proteolysis","display_name":"pericellular proteolysis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/zymogen-activation","display_name":"zymogen activation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/upa-receptor","display_name":"uPA receptor","score":0.652999997138977},{"id":"https://openalex.org/keywords/prostate-cancer-cells","display_name":"prostate cancer cells","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.8135260343551636},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.7709875106811523},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.6400353908538818},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.6249444484710693},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5241101980209351},{"id":"https://openalex.org/C2778775115","wikidata":"https://www.wikidata.org/wiki/Q245759","display_name":"Zymogen","level":3,"score":0.5205420255661011},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5189963579177856},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4370267391204834},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43015342950820923},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4230264127254486},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40754568576812744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3732810616493225},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.36294981837272644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3412589430809021},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2688151001930237},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09250548481941223},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1042/bj20091448","doi":"https://doi.org/10.1042/bj20091448","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20091448","pdf_url":"https://portlandpress.com/biochemj/article-pdf/426/2/219/733351/bj4260219.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:20015050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20015050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:31265","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/31265/1/Owen_et_al_2010.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/id/eprint/31265/1/Owen_et_al_2010.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:HAL:hal-00479257v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-00479257","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemical Journal, 2010, 426 (2), pp.219-228. &#x27E8;10.1042/BJ20091448&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:tara.tcd.ie:2262/45470","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2262/45470","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1042/bj20091448","doi":"https://doi.org/10.1042/bj20091448","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20091448","pdf_url":"https://portlandpress.com/biochemj/article-pdf/426/2/219/733351/bj4260219.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2067782874.pdf","grobid_xml":"https://content.openalex.org/works/W2067782874.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W61656967","https://openalex.org/W163717267","https://openalex.org/W1482629448","https://openalex.org/W1521047460","https://openalex.org/W1569704448","https://openalex.org/W1604744894","https://openalex.org/W1627231359","https://openalex.org/W1808819173","https://openalex.org/W1920441681","https://openalex.org/W1969275365","https://openalex.org/W1971131900","https://openalex.org/W1980839772","https://openalex.org/W1988015362","https://openalex.org/W1995012824","https://openalex.org/W1996534388","https://openalex.org/W2003183488","https://openalex.org/W2004937520","https://openalex.org/W2005638713","https://openalex.org/W2016021454","https://openalex.org/W2022527563","https://openalex.org/W2023135893","https://openalex.org/W2026280439","https://openalex.org/W2033458525","https://openalex.org/W2038221758","https://openalex.org/W2039135880","https://openalex.org/W2061697745","https://openalex.org/W2066917018","https://openalex.org/W2078686098","https://openalex.org/W2089905811","https://openalex.org/W2095253850","https://openalex.org/W2101356447","https://openalex.org/W2103700658","https://openalex.org/W2117735823","https://openalex.org/W2119542456","https://openalex.org/W2126942356","https://openalex.org/W2136390065","https://openalex.org/W2137466342","https://openalex.org/W2149781503","https://openalex.org/W2150966576","https://openalex.org/W2154982714"],"related_works":["https://openalex.org/W2026280439","https://openalex.org/W2076633367","https://openalex.org/W2044627672","https://openalex.org/W1598516408","https://openalex.org/W2792382529","https://openalex.org/W1980839772","https://openalex.org/W1524592672","https://openalex.org/W1003017956","https://openalex.org/W61656967","https://openalex.org/W2026344866"],"abstract_inverted_index":{"HGF":[0,81],"(hepatocyte":[1],"growth":[2],"factor)":[3],"is":[4,56],"a":[5,57,66,158,253],"pleiotropic":[6],"cytokine":[7],"homologous":[8],"to":[9,20,138,152,169,256],"the":[10,73,85,95,99,143,147,153,174,206,232,235],"serine":[11,103],"protease":[12,189],"zymogen":[13],"plasminogen":[14,50],"that":[15,54,247],"requires":[16],"canonical":[17],"proteolytic":[18],"cleavage":[19],"gain":[21],"functional":[22],"activity.":[23],"The":[24],"activating":[25],"proteases":[26],"are":[27,240],"key":[28],"components":[29],"of":[30,60,69,75,79,87,98,124,149,178,199,208,214,244],"its":[31],"regulation,":[32],"but":[33],"controversy":[34],"surrounds":[35],"their":[36,257],"identity.":[37],"Using":[38],"quantitative":[39],"analysis":[40],"we":[41],"found":[42,168],"no":[43],"evidence":[44],"for":[45,142,161],"activation":[46,113,155],"by":[47,65,180,187,212],"uPA":[48],"(urokinase":[49],"activator),":[51],"despite":[52],"reports":[53],"this":[55,162],"principal":[58],"activator":[59],"pro-HGF.":[61,224],"This":[62],"was":[63,185,210],"unaffected":[64],"wide":[67],"range":[68],"experimental":[70],"conditions,":[71],"including":[72,262],"use":[74],"various":[76],"molecular":[77],"forms":[78],"both":[80,188],"and":[82,84,106,116,191,197,238,246],"uPA,":[83],"presence":[86,207],"uPAR":[88],"(uPA":[89],"receptor)":[90],"or":[91],"heparin.":[92],"In":[93],"contrast":[94,230],"catalytic":[96],"domains":[97],"TTSPs":[100,165,236],"(type-II":[101],"transmembrane":[102],"proteases)":[104],"matriptase":[105,237],"hepsin":[107,150,239],"were":[108,136,166],"highly":[109],"efficient":[110,127,171],"activators":[111,172,243],"(50%":[112],"at":[114,120,173],"0.1":[115],"3.4":[117],"nM":[118],"respectively),":[119],"least":[121],"four":[122],"orders":[123],"magnitude":[125],"more":[126],"than":[128],"uPA.":[129],"PS-SCL":[130],"(positional-scanning":[131],"synthetic":[132],"combinatorial":[133],"peptide":[134],"libraries)":[135],"used":[137],"identify":[139],"consensus":[140],"sequences":[141],"TTSPs,":[144],"which":[145],"in":[146,205,229,259],"case":[148],"corresponded":[151],"pro-HGF":[154,179,209],"sequence,":[156],"demonstrating":[157],"high":[159],"specificity":[160],"reaction.":[163],"Both":[164],"also":[167,222],"be":[170],"cell":[175],"surface.":[176],"Activation":[177],"PC3":[181],"prostate":[182],"carcinoma":[183],"cells":[184,204,221],"abolished":[186,211],"inhibition":[190,213],"matriptase-targeting":[192],"siRNA":[193],"(small":[194],"interfering":[195],"RNA),":[196],"scattering":[198],"MDCK":[200],"(Madin-Darby":[201],"canine":[202],"kidney)":[203],"matriptase.":[215],"Hepsin-transfected":[216],"HEK":[217],"(human":[218],"embryonic":[219],"kidney)-293":[220],"activated":[223],"These":[225],"observations":[226],"demonstrate":[227],"that,":[228],"with":[231],"uPA/uPAR":[233],"system,":[234],"direct":[241],"pericellular":[242],"pro-HGF,":[245],"together":[248],"these":[249],"proteins":[250],"may":[251],"form":[252],"pathway":[254],"contributing":[255],"involvement":[258],"pathological":[260],"situations,":[261],"cancer.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
