{"id":"https://openalex.org/W2067767201","doi":"https://doi.org/10.1007/s13361-011-0298-2","title":"Automated Hydrogen/Deuterium Exchange Electron Transfer Dissociation High Resolution Mass Spectrometry Measured at Single-Amide Resolution","display_name":"Automated Hydrogen/Deuterium Exchange Electron Transfer Dissociation High Resolution Mass Spectrometry Measured at Single-Amide Resolution","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2067767201","doi":"https://doi.org/10.1007/s13361-011-0298-2","mag":"2067767201","pmid":"https://pubmed.ncbi.nlm.nih.gov/22131230","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3796066"},"language":"en","primary_location":{"id":"doi:10.1007/s13361-011-0298-2","doi":"https://doi.org/10.1007/s13361-011-0298-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13361-011-0298-2","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3796066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003475220","display_name":"Rachelle R. Landgraf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachelle R. Landgraf","raw_affiliation_strings":["Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072514849","display_name":"Michael J. Chalmers","orcid":"https://orcid.org/0000-0002-2139-6089","observed_orcids":["https://orcid.org/0000-0002-2139-6089"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Chalmers","raw_affiliation_strings":["Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000139914","display_name":"Patrick R. Griffin","orcid":"https://orcid.org/0000-0002-3404-690X","observed_orcids":["https://orcid.org/0000-0002-3404-690X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. Griffin","raw_affiliation_strings":["Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA","The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"The Scripps Research Institute, Scripps Florida, 130 Scripps Way #2A2, 33458, Jupiter, FL, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.5197,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.95918514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"23","issue":"2","first_page":"301","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange-mass-spectrometry","display_name":"hydrogen-deuterium exchange mass spectrometry","score":0.9599999785423279},{"id":"https://openalex.org/keywords/electron-transfer-dissociation","display_name":"electron transfer dissociation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.4749999940395355},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.9559999704360962},{"id":"https://openalex.org/keywords/bottom-up-proteomics","display_name":"shotgun proteomics","score":0.7160000205039978},{"id":"https://openalex.org/keywords/soft-ionization","display_name":"soft ionization","score":0.703000009059906},{"id":"https://openalex.org/keywords/desolvation","display_name":"desolvation","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9304676055908203},{"id":"https://openalex.org/C2780841973","wikidata":"https://www.wikidata.org/wiki/Q2607924","display_name":"Orbitrap","level":3,"score":0.8369743824005127},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.7879012227058411},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.7259756326675415},{"id":"https://openalex.org/C2777109674","wikidata":"https://www.wikidata.org/wiki/Q3710342","display_name":"Electron-transfer dissociation","level":4,"score":0.7228620648384094},{"id":"https://openalex.org/C2776982924","wikidata":"https://www.wikidata.org/wiki/Q3710340","display_name":"Electron-capture dissociation","level":4,"score":0.587756872177124},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.5576255917549133},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.44875630736351013},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4244707226753235},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.4231330156326294},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.41366082429885864},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3756351172924042},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.2459927499294281},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20955431461334229},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.13791966438293457},{"id":"https://openalex.org/C184779094","wikidata":"https://www.wikidata.org/wiki/Q26383","display_name":"Atomic physics","level":1,"score":0.06572100520133972},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06074437499046326},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004583","descriptor_name":"Electrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D041961","descriptor_name":"Deuterium Exchange Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s13361-011-0298-2","doi":"https://doi.org/10.1007/s13361-011-0298-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13361-011-0298-2","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:22131230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22131230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2787069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3796066","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3796066","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3796066","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Soc Mass Spectrom","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.654.5533","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.654.5533","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://download.springer.com/static/pdf/681/art%3A10.1007/s13361-011-0298-2.pdf?auth66%3D1417933853_e88dc823e2e6d52f2f909f8c122bb2a5%26ext%3D.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2787069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3796066","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6433172018","display_name":"Acquisition of a LTQ/Orbitrap MS to advance the study of protein dynamics","funder_award_id":"S10RR027270","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8951910630","display_name":"Development of H/D exchange technology for the study of large protein complexes","funder_award_id":"R01GM084041","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W88247729","https://openalex.org/W1562261045","https://openalex.org/W1966510993","https://openalex.org/W1969437387","https://openalex.org/W1974900044","https://openalex.org/W1975353500","https://openalex.org/W1977491484","https://openalex.org/W1980527803","https://openalex.org/W1980956486","https://openalex.org/W1984588332","https://openalex.org/W1989026274","https://openalex.org/W1990126142","https://openalex.org/W2006343974","https://openalex.org/W2012421127","https://openalex.org/W2023115763","https://openalex.org/W2023904435","https://openalex.org/W2027702484","https://openalex.org/W2060158060","https://openalex.org/W2075741153","https://openalex.org/W2077111041","https://openalex.org/W2079080809","https://openalex.org/W2083319939","https://openalex.org/W2083964850","https://openalex.org/W2084061737","https://openalex.org/W2084370050","https://openalex.org/W2089048180","https://openalex.org/W2089409283","https://openalex.org/W2091609997","https://openalex.org/W2107006579","https://openalex.org/W2114320763","https://openalex.org/W2121454015","https://openalex.org/W2127125241","https://openalex.org/W2131918208","https://openalex.org/W2157821312","https://openalex.org/W2168747115","https://openalex.org/W2170036411","https://openalex.org/W2318299980"],"related_works":["https://openalex.org/W1974900044","https://openalex.org/W7014854947","https://openalex.org/W2790877478","https://openalex.org/W2587887465","https://openalex.org/W1974850706","https://openalex.org/W3023803597","https://openalex.org/W1986173457","https://openalex.org/W3026620720","https://openalex.org/W2734517989","https://openalex.org/W4414166927"],"abstract_inverted_index":{"Hydrogen":[0],"deuterium":[1,16,50,100],"exchange":[2],"mass":[3,61],"spectrometry":[4],"(HDX-MS)":[5],"is":[6,91],"a":[7,68,87,107],"well":[8],"established":[9,135],"method":[10],"for":[11,94,102,146,165],"the":[12,37,60,78,166],"measurement":[13],"of":[14,36,70,106,149,175],"solution-phase":[15],"incorporation":[17,51,101],"into":[18,24,133],"proteins,":[19],"which":[20],"can":[21,123,130],"provide":[22],"insight":[23],"protein":[25,38],"conformational":[26],"mobility.":[27],"However,":[28],"most":[29],"HDX":[30,104,139,144,163],"measurements":[31],"are":[32,116],"constrained":[33],"to":[34,118,126,157],"regions":[35],"where":[39],"pepsin":[40],"proteolysis":[41],"allows":[42],"detection":[43],"at":[44],"peptide":[45],"resolution.":[46],"Recently,":[47],"single-amide":[48,99,143],"resolution":[49,162],"has":[52],"been":[53],"achieved":[54],"by":[55,66],"limiting":[56],"gas-phase":[57],"scrambling":[58,128],"in":[59,97],"spectrometer.":[62],"This":[63],"was":[64],"accomplished":[65],"employing":[67],"combination":[69],"soft":[71],"ionization":[72],"and":[73,129,136],"desolvation":[74],"conditions":[75],"coupled":[76],"with":[77,172],"radical-driven":[79],"fragmentation":[80],"technique":[81],"electron":[82],"transfer":[83],"dissociation":[84],"(ETD).":[85],"Here,":[86],"hybrid":[88],"LTQ-Orbitrap":[89],"XL":[90],"systematically":[92],"evaluated":[93],"its":[95],"utility":[96],"providing":[98],"differential":[103,142,159],"analysis":[105,148],"nuclear":[108],"receptor":[109,170],"upon":[110],"binding":[111],"small":[112],"molecule":[113],"ligands.":[114],"We":[115,152],"able":[117],"show":[119],"that":[120],"instrumental":[121],"parameters":[122],"be":[124,131],"optimized":[125],"minimize":[127],"incorporated":[132],"an":[134],"fully":[137],"automated":[138],"platform":[140],"making":[141],"possible":[145],"bottom-up":[147],"complex":[150],"systems.":[151],"have":[153],"applied":[154],"this":[155],"system":[156],"determine":[158],"single":[160],"amide":[161],"data":[164],"peroxizome":[167],"proliferator":[168],"activated":[169],"bound":[171],"two":[173],"ligands":[174],"interest.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}