{"id":"https://openalex.org/W2067729949","doi":"https://doi.org/10.1073/pnas.0807269105","title":"NF-IL6 (C/EBP\u03b2) induces HIV-1 replication by inhibiting cytidine deaminase APOBEC3G","display_name":"NF-IL6 (C/EBP\u03b2) induces HIV-1 replication by inhibiting cytidine deaminase APOBEC3G","publication_year":2008,"publication_date":"2008-09-22","ids":{"openalex":"https://openalex.org/W2067729949","doi":"https://doi.org/10.1073/pnas.0807269105","mag":"2067729949","pmid":"https://pubmed.ncbi.nlm.nih.gov/18809921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2567486"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0807269105","doi":"https://doi.org/10.1073/pnas.0807269105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0807269105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2567486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109113819","display_name":"Shigemi M. Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigemi M. Kinoshita","raw_affiliation_strings":["Laboratory of Combined Research on Microbiology and Immunology, Research Institute of Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Combined Research on Microbiology and Immunology, Research Institute of Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061528650","display_name":"Shizuka Taguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shizuka Taguchi","raw_affiliation_strings":["Laboratory of Combined Research on Microbiology and Immunology, Research Institute of Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan","Communicated by Tadamitsu Kishimoto, Osaka University, Osaka, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Combined Research on Microbiology and Immunology, Research Institute of Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Communicated by Tadamitsu Kishimoto, Osaka University, Osaka, Japan,","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4487,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.59666975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"105","issue":"39","first_page":"15022","last_page":"15027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-il6","display_name":"NF-IL6","score":0.9810000061988831},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.902999997138977},{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.9959999918937683},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.5699999928474426},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/reverse-transcription","display_name":"reverse transcription","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cytidine-deaminase","display_name":"cytidine deaminase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vif","display_name":"Vif","score":0.5640000104904175},{"id":"https://openalex.org/keywords/dna-deamination","display_name":"DNA deamination","score":0.7789999842643738},{"id":"https://openalex.org/keywords/antiviral-restriction-factors","display_name":"antiviral restriction factors","score":0.6620000004768372},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2781310106","wikidata":"https://www.wikidata.org/wiki/Q14916265","display_name":"APOBEC3G","level":4,"score":0.9537755250930786},{"id":"https://openalex.org/C2776985229","wikidata":"https://www.wikidata.org/wiki/Q18021211","display_name":"Cytidine deaminase","level":3,"score":0.9514696598052979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6088682413101196},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5978997945785522},{"id":"https://openalex.org/C27082348","wikidata":"https://www.wikidata.org/wiki/Q21108149","display_name":"Activation-induced (cytidine) deaminase","level":5,"score":0.5557041168212891},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49723270535469055},{"id":"https://openalex.org/C2781184954","wikidata":"https://www.wikidata.org/wiki/Q422538","display_name":"Cytidine","level":3,"score":0.4276985228061676},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42345130443573},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3546779453754425},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3420122563838959},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32225704193115234},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2578086853027344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1718117892742157},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15047034621238708},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14636462926864624},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.13981574773788452},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13609102368354797},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.11567133665084839},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.08697298169136047}],"mesh":[{"descriptor_ui":"D000071480","descriptor_name":"APOBEC-3G Deaminase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022782","descriptor_name":"CCAAT-Enhancer-Binding Protein-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022782","descriptor_name":"CCAAT-Enhancer-Binding Protein-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0807269105","doi":"https://doi.org/10.1073/pnas.0807269105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0807269105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2567486","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2567486","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18809921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18809921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2567486","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2567486","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W78635780","https://openalex.org/W179818011","https://openalex.org/W1528349601","https://openalex.org/W1541336235","https://openalex.org/W1796915314","https://openalex.org/W1952023345","https://openalex.org/W1964842789","https://openalex.org/W1966343819","https://openalex.org/W1966706511","https://openalex.org/W1972805802","https://openalex.org/W1991069890","https://openalex.org/W1993897877","https://openalex.org/W2001243226","https://openalex.org/W2001375348","https://openalex.org/W2004640739","https://openalex.org/W2008527950","https://openalex.org/W2011700223","https://openalex.org/W2012564250","https://openalex.org/W2017585121","https://openalex.org/W2019508559","https://openalex.org/W2023035407","https://openalex.org/W2029884547","https://openalex.org/W2039773345","https://openalex.org/W2042042897","https://openalex.org/W2048959161","https://openalex.org/W2050389359","https://openalex.org/W2051242500","https://openalex.org/W2057295852","https://openalex.org/W2063337242","https://openalex.org/W2081550460","https://openalex.org/W2083719082","https://openalex.org/W2086693765","https://openalex.org/W2089307417","https://openalex.org/W2089478514","https://openalex.org/W2104171891","https://openalex.org/W2110305747","https://openalex.org/W2118133351","https://openalex.org/W2141255724","https://openalex.org/W2144425084","https://openalex.org/W2152630682","https://openalex.org/W2158884355","https://openalex.org/W2165608602","https://openalex.org/W2327006078","https://openalex.org/W4232273699","https://openalex.org/W4300659364"],"related_works":["https://openalex.org/W7100046689","https://openalex.org/W2086693765","https://openalex.org/W1515041121","https://openalex.org/W2069676221","https://openalex.org/W2305136937","https://openalex.org/W2075049040","https://openalex.org/W2056750717","https://openalex.org/W7098280635","https://openalex.org/W1970288540","https://openalex.org/W2347695229"],"abstract_inverted_index":{"T":[0,12,40,139],"cell":[1,140],"activation":[2,134],"is":[3,16,100],"crucial":[4],"for":[5,44,125],"the":[6,19,29,52,59,83,133],"productive":[7],"HIV-1":[8,45,78,90,108,120,136],"infection":[9],"of":[10,51,85,89,104,135,148],"primary":[11,38],"cells;":[13],"however,":[14],"little":[15],"known":[17],"about":[18],"host":[20,30,141],"molecules":[21,142],"involved":[22,117],"in":[23,66,91,118],"this":[24],"process.":[25],"We":[26],"show":[27],"that":[28,98,106,115],"transcription":[31,50],"factor":[32],"NF-IL6":[33,47,67,80,99],"(also":[34],"called":[35],"C/EBPbeta)":[36],"renders":[37],"CD4(+)":[39],"cells":[41],"highly":[42],"permissive":[43],"replication.":[46,79,109],"facilitates":[48,107],"reverse":[49],"virus":[53],"by":[54,138,151],"binding":[55,72],"to":[56,73],"and":[57,75,143,153],"inhibiting":[58],"antiviral":[60],"cytidine":[61],"deaminase":[62],"APOBEC3G.":[63],"A":[64],"mutation":[65],"at":[68],"Ser-288":[69],"weakened":[70],"its":[71],"APOBEC3G":[74,105,152],"strongly":[76],"inhibited":[77],"also":[81],"induced":[82],"replication":[84,121,137],"a":[86,101,145],"Vif-deficient":[87],"strain":[88],"nonpermissive":[92],"HUT78":[93],"cells.":[94],"These":[95],"data":[96],"indicate":[97],"natural":[102],"inhibitor":[103],"Host":[110],"factors,":[111],"such":[112],"as":[113],"NF-IL6,":[114],"are":[116,122],"early":[119],"potential":[123],"targets":[124],"anti-HIV-1":[126],"therapy.":[127],"Our":[128],"findings":[129],"shed":[130],"light":[131],"on":[132],"reveal":[144],"unique":[146],"regulation":[147],"DNA":[149],"deamination":[150],"NF-IL6.":[154]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}