{"id":"https://openalex.org/W2067676237","doi":"https://doi.org/10.1073/pnas.85.24.9866","title":"Use of antiserum to neurotensin reveals a physiological role for the peptide in rat prolactin release.","display_name":"Use of antiserum to neurotensin reveals a physiological role for the peptide in rat prolactin release.","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W2067676237","doi":"https://doi.org/10.1073/pnas.85.24.9866","mag":"2067676237","pmid":"https://pubmed.ncbi.nlm.nih.gov/3200862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/282882"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.85.24.9866","doi":"https://doi.org/10.1073/pnas.85.24.9866","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.85.24.9866","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/282882","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030124668","display_name":"Edathil Vijayan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"E Vijayan","raw_affiliation_strings":["School of Life Sciences, University of Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015979266","display_name":"Robert E. Carraway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R Carraway","raw_affiliation_strings":["School of Life Sciences, University of Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053523675","display_name":"Susan E. Leeman","orcid":"https://orcid.org/0000-0003-2875-1394","observed_orcids":["https://orcid.org/0000-0003-2875-1394"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S E Leeman","raw_affiliation_strings":["School of Life Sciences, University of Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069185819","display_name":"Samuel M. McCann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S M McCann","raw_affiliation_strings":["School of Life Sciences, University of Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36893310"],"apc_list":null,"apc_paid":null,"fwci":0.1247,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.33870374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"85","issue":"24","first_page":"9866","last_page":"9869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.3869999945163727,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.3869999945163727,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.2517000138759613,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prolactin-secretion","display_name":"prolactin secretion","score":0.8539999723434448},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.6800000071525574},{"id":"https://openalex.org/keywords/lactotrophs","display_name":"lactotrophs","score":0.8270000219345093},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7639999985694885},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7990000247955322},{"id":"https://openalex.org/keywords/intraventricular-injection","display_name":"intraventricular injection","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.9250289797782898},{"id":"https://openalex.org/C2778976297","wikidata":"https://www.wikidata.org/wiki/Q419576","display_name":"Neurotensin","level":4,"score":0.9010588526725769},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8520144820213318},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8507667779922485},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.8327226638793945},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.8123440742492676},{"id":"https://openalex.org/C54799321","wikidata":"https://www.wikidata.org/wiki/Q3016161","display_name":"Prolactin cell","level":4,"score":0.5721042156219482},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5542819499969482},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4361761510372162},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.42364221811294556},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4102104902267456},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37751537561416626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36081475019454956},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.31916576623916626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22503536939620972},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14916741847991943},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08087056875228882},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0646803081035614}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.85.24.9866","doi":"https://doi.org/10.1073/pnas.85.24.9866","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.85.24.9866","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:282882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/282882","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3200862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3200862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:2740058286","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Robert_Carraway/publication/19955159_Use_of_antiserum_to_neurotensin_reveals_a_physiological_role_for_the_peptide_in_rat_prolactin_release/links/53e279210cf275a5fdd86be1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:282882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/282882","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G374541617","display_name":null,"funder_award_id":"HD09988-12","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W421259464","https://openalex.org/W620834878","https://openalex.org/W1485697636","https://openalex.org/W1520864645","https://openalex.org/W1529689987","https://openalex.org/W1965745216","https://openalex.org/W1972544656","https://openalex.org/W1975961987","https://openalex.org/W2016662839","https://openalex.org/W2029874337","https://openalex.org/W2031205382","https://openalex.org/W2039063989","https://openalex.org/W2052470257","https://openalex.org/W2052969077","https://openalex.org/W2054161577","https://openalex.org/W2066424490","https://openalex.org/W2091129282","https://openalex.org/W2202263696","https://openalex.org/W2328162438"],"related_works":["https://openalex.org/W2036432279","https://openalex.org/W2070860247","https://openalex.org/W1975840004","https://openalex.org/W2323388216","https://openalex.org/W2016662839","https://openalex.org/W2054993340","https://openalex.org/W2068078193","https://openalex.org/W2405022112","https://openalex.org/W3044572016","https://openalex.org/W2033082439"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"indicated":[3],"that":[4,274],"the":[5,17,24,34,39,45,48,62,71,85,123,127,169,172,175,178,194,201,233,243,251,255,281,288],"brain":[6],"peptide":[7,289],"neurotensin":[8,67,77,95,143,260],"can":[9],"stimulate":[10],"prolactin":[11,54,100,150,212,244,262,278,291],"release":[12,35,245,273,292,296],"by":[13,33,69,268,280],"direct":[14,284],"action":[15,22,30],"on":[16,174,242,261,290],"pituitary":[18,50,176],"gland,":[19],"whereas":[20],"its":[21,269,294],"within":[23,112],"hypothalamus":[25],"is":[26,31],"inhibitory.":[27],"The":[28,117,283],"inhibitory":[29,257],"mediated":[32,267],"of":[36,65,74,88,94,115,139,142,171,186,198,204,210,236,254,259,271,287],"dopamine":[37,272],"into":[38,84,297],"hypophyseal":[40],"portal":[41,298],"veins,":[42],"which":[43,154,189,264],"deliver":[44],"neurotransmitter":[46],"to":[47,52,60,192,302],"anterior":[49],"gland":[51],"inhibit":[53],"release.":[55],"Our":[56],"experiments":[57],"were":[58,155],"done":[59],"evaluate":[61,168],"physiologic":[63],"significance":[64,253],"these":[66,140],"actions":[68,258],"injecting":[70],"globulin":[72],"fraction":[73],"highly":[75,207],"specific":[76],"antiserum":[78,96,144,173,179,237],"either":[79,89],"intravenously":[80,182],"or":[81,91],"intraventricularly.":[82],"Injection":[83],"third":[86],"ventricle":[87],"1":[90,113,219],"3":[92],"microliter":[93],"significantly":[97],"increased":[98],"plasma":[99,149,211],"concentrations":[101],"in":[102,122,126,148,151,159,164,223,246,275,306,310],"(i)":[103],"ovariectomized":[104,107,124,128,225,227],"and":[105,109,130,133,226,229],"(ii)":[106],"estrogen-":[108,129,228],"progesterone-primed":[110],"rats":[111],"hr":[114,220],"injection.":[116],"response":[118],"was":[119,134,180,190],"more":[120],"pronounced":[121],"than":[125,161],"progesterone-treated":[131,230],"animals":[132],"dose":[135,185],"related.":[136],"Intraventricular":[137],"injection":[138,203,222,235],"doses":[141],"also":[145,300],"evoked":[146],"elevations":[147],"intact":[152],"males,":[153],"significant":[156,208,240,305],"but":[157,308],"smaller":[158],"magnitude":[160],"those":[162],"seen":[163],"female":[165,307],"rats.":[166,312],"To":[167],"effect":[170,197,241,286],"directly,":[177],"injected":[181],"at":[183,218],"a":[184,206],"40":[187],"microliter,":[188],"sufficient":[191],"block":[193],"blood":[195],"pressure-lowering":[196],"neurotensin.":[199],"After":[200],"intravenous":[202,234],"antiserum,":[205],"suppression":[209],"occurred,":[213],"detectable":[214],"when":[215],"first":[216],"measured":[217],"after":[221,293],"both":[224],"animals;":[231],"however,":[232],"had":[238],"no":[239],"males.":[247],"These":[248],"data":[249],"indicate":[250],"physiological":[252],"hypothalamic":[256],"release,":[263],"are":[265],"probably":[266],"stimulation":[270],"turn,":[276],"inhibits":[277],"secretion":[279],"lactotropes.":[282],"stimulatory":[285],"presumed":[295],"vessels":[299],"appears":[301],"be":[303],"physiologically":[304],"not":[309],"male":[311]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}