{"id":"https://openalex.org/W2067553641","doi":"https://doi.org/10.1210/endo-109-6-2129","title":"Effects of Withdrawal of Exogenous Estradiol from Pseudopregnant Rabbits: Transient Nature of Loss of Luteal Function and Reversal of Estradiol-Induced Suppression of Luteinizing Hormone-Responsive Adenylyl Cyclase*","display_name":"Effects of Withdrawal of Exogenous Estradiol from Pseudopregnant Rabbits: Transient Nature of Loss of Luteal Function and Reversal of Estradiol-Induced Suppression of Luteinizing Hormone-Responsive Adenylyl Cyclase*","publication_year":1981,"publication_date":"1981-12-01","ids":{"openalex":"https://openalex.org/W2067553641","doi":"https://doi.org/10.1210/endo-109-6-2129","mag":"2067553641","pmid":"https://pubmed.ncbi.nlm.nih.gov/7308145"},"language":"en","primary_location":{"id":"doi:10.1210/endo-109-6-2129","doi":"https://doi.org/10.1210/endo-109-6-2129","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-109-6-2129","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005853750","display_name":"HOWARD J. KIRCHICK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HOWARD J. KIRCHICK","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003363567","display_name":"Lutz Birnbaumer","orcid":"https://orcid.org/0000-0002-0775-8661","observed_orcids":["https://orcid.org/0000-0002-0775-8661"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LUTZ BIRNBAUMER","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.9004,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.84388624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":"6","first_page":"2129","last_page":"2137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.19760000705718994,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol-withdrawal","display_name":"estradiol withdrawal","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pseudopregnancy","display_name":"pseudopregnancy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/luteal-function","display_name":"luteal function","score":0.9229999780654907},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.7509999871253967},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8130000233650208},{"id":"https://openalex.org/keywords/estradiol-implants","display_name":"estradiol implants","score":0.6000000238418579},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.8969104290008545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8274807333946228},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8210495710372925},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.815711498260498},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6778910160064697},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5103606581687927},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4469279646873474},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36196231842041016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35830068588256836},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3546532988548279}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003338","descriptor_name":"Corpus Luteum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011555","descriptor_name":"Pseudopregnancy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011555","descriptor_name":"Pseudopregnancy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011555","descriptor_name":"Pseudopregnancy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-109-6-2129","doi":"https://doi.org/10.1210/endo-109-6-2129","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-109-6-2129","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:7308145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7308145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1589012184","https://openalex.org/W1775749144","https://openalex.org/W1976672483","https://openalex.org/W1980378132","https://openalex.org/W1988516065","https://openalex.org/W2010033349","https://openalex.org/W2011496918","https://openalex.org/W2020349910","https://openalex.org/W2024869257","https://openalex.org/W2025827819","https://openalex.org/W2030093264","https://openalex.org/W2033708327","https://openalex.org/W2052104297","https://openalex.org/W2081343590","https://openalex.org/W2084062854","https://openalex.org/W2089054270","https://openalex.org/W2089717147","https://openalex.org/W2096952529","https://openalex.org/W2103413038","https://openalex.org/W2112941528","https://openalex.org/W2115224323","https://openalex.org/W2128038771","https://openalex.org/W2144655531","https://openalex.org/W2148498532","https://openalex.org/W2169503005","https://openalex.org/W2316453664"],"related_works":["https://openalex.org/W2148498532","https://openalex.org/W2020950940","https://openalex.org/W1986238933","https://openalex.org/W2033708327","https://openalex.org/W265313636","https://openalex.org/W2122238951","https://openalex.org/W1988516065","https://openalex.org/W2119393463","https://openalex.org/W2030093264","https://openalex.org/W2076933493"],"abstract_inverted_index":{"We":[0,264],"have":[1],"reported":[2,112,278],"in":[3,16,46,206,210],"recent":[4],"studies":[5],"that":[6,155,191,267,275],"exogenous":[7,118,203,270,282],"estradiol":[8],"(E2)":[9],"suppresses":[10],"luteal":[11,136,229],"LH-responsive":[12,137,174,230,248],"adenylyl":[13,138,175,231,249],"cyclase":[14,176,232,250],"activity":[15,177,233],"pseudopregnant":[17,49],"rabbits.":[18,50],"The":[19,76],"purpose":[20],"of":[21,54,90,100,165,202,223,253,269],"the":[22,56,91,135,141,145,157,180,276,287],"present":[23],"study":[24],"was":[25,150],"to":[26,144,169,190,236,286],"determine":[27],"whether":[28],"this":[29],"suppression":[30,142],"is":[31,284],"reversible.":[32],"High":[33],"or":[34,40,71],"low":[35,67,77,130,146,170,196],"level":[36,58,68,78,131,147,159,171,181,187,197],"E2-filled":[37],"Silastic":[38],"capsules":[39,42,83],"empty":[41,74,82],"were":[43,61,84,95,256],"sc":[44],"implanted":[45],"day":[47,52],"5":[48],"On":[51],"8":[53],"pseudopregnancy,":[55],"high":[57,128,158,168,186],"E2":[59,69,79,119,132,148,160,172,188,198,204,239,271,283],"implants":[60,80,133,149,240],"either":[62],"sham":[63,85],"replaced,":[64],"replaced":[65,72],"with":[66,73,185,195],"implants,":[70,173],"capsules.":[75],"and":[81,105,129,228,246,274],"replaced.":[86],"Animals":[87],"from":[88,167,179],"each":[89],"five":[92],"resulting":[93],"groups":[94],"killed":[96],"on":[97],"days":[98,107,222],"9-12":[99],"pseudopregnancy":[101],"(1,":[102],"2,":[103],"3,":[104],"4":[106,221],"postimplant":[108],"manipulation).":[109],"As":[110],"previously":[111,277],"using":[113],"an":[114],"intermittent":[115],"injection":[116],"protocol,":[117],"had":[120,234],"little":[121],"effect":[122],"upon":[123,281],"serum":[124,211,226,243],"progesterone":[125,212,227],"concentrations.":[126],"Both":[127,252],"suppressed":[134,242],"cyclase,":[139],"but":[140],"due":[143],"not":[151],"as":[152,154,214],"great":[153],"for":[156,183,193],"implants.":[161],"Within":[162],"24":[163],"h":[164,260],"switching":[166],"increased":[178],"found":[182,192],"animals":[184,194],"throughout":[189],"throughout.":[199],"Total":[200],"withdrawal":[201],"resulted":[205],"a":[207],"precipitous":[208],"fall":[209],"concentrations,":[213],"predicted":[215],"by":[216],"previous":[217],"studies.":[218],"However,":[219],"within":[220,258],"withdrawal,":[224],"both":[225],"returned":[235],"control":[237],"values.":[238],"also":[241],"LH":[244],"concentrations":[245],"follicular":[247],"activities.":[251],"these":[254],"effects":[255,268],"reversed":[257],"24-48":[259],"after":[261],"implant":[262],"withdrawal.":[263],"conclude,":[265],"therefore,":[266],"are":[272],"reversible":[273],"E2-induced":[279],"dependency":[280],"related":[285],"experimental":[288],"protocol":[289],"used.":[290]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}