{"id":"https://openalex.org/W206752637","doi":null,"title":"Comparative investigation on the cardio-protective action of the beta-blockers carazolol, propranolol and pindolol in rats.","display_name":"Comparative investigation on the cardio-protective action of the beta-blockers carazolol, propranolol and pindolol in rats.","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W206752637","mag":"206752637","pmid":"https://pubmed.ncbi.nlm.nih.gov/6119093"},"language":"en","primary_location":{"id":"pmid:6119093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6119093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062151654","display_name":"W. Bartsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Bartsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045861202","display_name":"Gisbert Sponer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Sponer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083735645","display_name":"K Dietmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Dietmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002950929","display_name":"Malcolm Kohler","orcid":"https://orcid.org/0000-0003-1800-8003","observed_orcids":["https://orcid.org/0000-0003-1800-8003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kohler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.01802584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"11","first_page":"1885","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8849999904632568},{"id":"https://openalex.org/keywords/carazolol","display_name":"carazolol","score":0.9330000281333923},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.996999979019165},{"id":"https://openalex.org/keywords/pindolol","display_name":"pindolol","score":1.0},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9710000157356262},{"id":"https://openalex.org/keywords/myocardial-hypoxia","display_name":"myocardial hypoxia","score":0.7160000205039978},{"id":"https://openalex.org/keywords/isoprenaline-induced-cardiotoxicity","display_name":"isoprenaline-induced cardiotoxicity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cardiac-necrosis","display_name":"cardiac necrosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/glycogen-depletion","display_name":"glycogen depletion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tachycardia","display_name":"tachycardia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2778499207","wikidata":"https://www.wikidata.org/wiki/Q418101","display_name":"Pindolol","level":3,"score":0.9274920225143433},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.8096582889556885},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.8057504296302795},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.544729471206665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5099414587020874},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5098751783370972},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4926460385322571},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38506752252578735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3638898730278015},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.1612820327281952},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010869","descriptor_name":"Pindolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6119093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6119093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},{"id":"mag:206752637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6119093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4318609211","https://openalex.org/W2415806273","https://openalex.org/W2085366574","https://openalex.org/W2409468550","https://openalex.org/W2064121075","https://openalex.org/W94130875","https://openalex.org/W2033254898","https://openalex.org/W2438663591","https://openalex.org/W2431876387","https://openalex.org/W2083593256"],"abstract_inverted_index":{"A":[0],"comparative":[1],"study":[2],"of":[3,65,88,94,109,111],"the":[4,26,32,63,83,86,92,107,112,117],"beta-receptor":[5],"blockers":[6],"propranolol,":[7],"pindolol":[8,47],"and":[9,52,91],"carazolol,":[10],"with":[11],"respect":[12],"to":[13],"their":[14],"cardio-protective":[15],"properties":[16],"against":[17,34,62,85],"stress":[18,124],"(hypoxia":[19],"or":[20],"isoprenaline":[21,98],"injection)":[22],"in":[23],"rats":[24],"showed":[25],"following.":[27],"The":[28,102],"beta-blockers":[29,60,118],"investigated":[30],"protected":[31,61],"heart":[33],"glycogen":[35],"depletion":[36],"during":[37],"hypoxia.":[38],"Carazolol":[39],"was":[40],"active":[41],"at":[42],"considerably":[43],"lower":[44],"doses":[45],"than":[46],"(about":[48,54],"25":[49],"times":[50,56],"less)":[51],"propranolol":[53],"100":[55],"later).":[57],"All":[58],"three":[59],"induction":[64],"cardiac":[66,89,120],"necroses":[67,90],"by":[68,97,115,123],"isoprenaline,":[69],"but":[70],"only":[71],"carazolol":[72],"produced":[73],"almost":[74],"complete":[75],"protection.":[76],"There":[77],"is":[78],"a":[79],"good":[80],"correlation":[81],"between":[82],"protection":[84],"development":[87],"inhibition":[93],"tachycardia":[95],"induced":[96,122],"(r":[99],"=":[100],"0.96).":[101],"results":[103],"are":[104],"discussed":[105],"from":[106],"point":[108],"view":[110],"possible":[113],"mechanisms":[114],"which":[116],"prevent":[119],"damage":[121],"situations.":[125]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
