{"id":"https://openalex.org/W2067520405","doi":"https://doi.org/10.1021/ja0537474","title":"Temperature-Sensitive Micrometer-Thick Layers of Hyaluronan Grafted on Microspheres","display_name":"Temperature-Sensitive Micrometer-Thick Layers of Hyaluronan Grafted on Microspheres","publication_year":2006,"publication_date":"2006-01-04","ids":{"openalex":"https://openalex.org/W2067520405","doi":"https://doi.org/10.1021/ja0537474","mag":"2067520405","pmid":"https://pubmed.ncbi.nlm.nih.gov/16433527"},"language":"en","primary_location":{"id":"doi:10.1021/ja0537474","doi":"https://doi.org/10.1021/ja0537474","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja0537474","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046468644","display_name":"Derk Joester","orcid":"https://orcid.org/0000-0002-9663-3309","observed_orcids":["https://orcid.org/0000-0002-9663-3309"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Derk Joester","raw_affiliation_strings":["Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074633729","display_name":"Eugenia Klein","orcid":"https://orcid.org/0000-0002-1061-8731","observed_orcids":["https://orcid.org/0000-0002-1061-8731"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E. Klein","raw_affiliation_strings":["Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046264807","display_name":"Benjamin Geiger","orcid":"https://orcid.org/0000-0001-8559-6373","observed_orcids":["https://orcid.org/0000-0001-8559-6373"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Benjamin Geiger","raw_affiliation_strings":["Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052255439","display_name":"Lia Addadi","orcid":"https://orcid.org/0000-0003-1693-648X","observed_orcids":["https://orcid.org/0000-0003-1693-648X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lia Addadi","raw_affiliation_strings":["Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Departments of Structural Biology and Molecular Cell Biology and Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0573,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.84101599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"128","issue":"4","first_page":"1119","last_page":"1124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.1881999969482422,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":1.0},{"id":"https://openalex.org/keywords/polyelectrolyte-layer","display_name":"polyelectrolyte layer","score":0.7310000061988831},{"id":"https://openalex.org/keywords/photografting","display_name":"photografting","score":0.7620000243186951},{"id":"https://openalex.org/keywords/polystyrene-microspheres","display_name":"polystyrene microspheres","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6679999828338623},{"id":"https://openalex.org/keywords/environmental-scanning-electron-microscopy","display_name":"environmental scanning electron microscopy","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.877408504486084},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.5463415384292603},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5246617794036865},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.5090391039848328},{"id":"https://openalex.org/C55171895","wikidata":"https://www.wikidata.org/wiki/Q268401","display_name":"Environmental scanning electron microscope","level":3,"score":0.47011318802833557},{"id":"https://openalex.org/C68928338","wikidata":"https://www.wikidata.org/wiki/Q131790","display_name":"Adhesive","level":3,"score":0.46630585193634033},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.4146754741668701},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.31638103723526},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.2435566782951355},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.12241208553314209},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028581","descriptor_name":"Lanthanoid Series Elements","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja0537474","doi":"https://doi.org/10.1021/ja0537474","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja0537474","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:16433527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16433527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1948756557","https://openalex.org/W1963554941","https://openalex.org/W1964590612","https://openalex.org/W1975463680","https://openalex.org/W1980603093","https://openalex.org/W1992710385","https://openalex.org/W1993761900","https://openalex.org/W2003432983","https://openalex.org/W2004054243","https://openalex.org/W2005307876","https://openalex.org/W2010945991","https://openalex.org/W2014520611","https://openalex.org/W2023313908","https://openalex.org/W2029563775","https://openalex.org/W2041078877","https://openalex.org/W2044181087","https://openalex.org/W2046945615","https://openalex.org/W2054854945","https://openalex.org/W2078753505","https://openalex.org/W2079199751","https://openalex.org/W2084905196","https://openalex.org/W2088373939","https://openalex.org/W2089232392","https://openalex.org/W2089764248","https://openalex.org/W2090476704","https://openalex.org/W2092158177","https://openalex.org/W2105608136","https://openalex.org/W2118165386","https://openalex.org/W2130093942","https://openalex.org/W2140225232","https://openalex.org/W2152682817"],"related_works":["https://openalex.org/W2006143794","https://openalex.org/W2058864000","https://openalex.org/W1987667211","https://openalex.org/W7095602467","https://openalex.org/W75305485","https://openalex.org/W2017109898","https://openalex.org/W4321254243","https://openalex.org/W2061444420","https://openalex.org/W2025566830","https://openalex.org/W2075075502"],"abstract_inverted_index":{"The":[0,114,132,163],"giant":[1],"polyelectrolyte":[2],"glycosaminoglycan":[3],"hyaluronan":[4,81,101,145],"(1-10":[5],"MDa)":[6],"is":[7,22,138,152],"a":[8,16,96,167,181],"major":[9],"component":[10],"of":[11,18,28,80,92,98,102,135,144,160,184],"the":[12,67,76,90,136,139],"pericellular":[13,34,68],"coat":[14,69,97,116,165],"on":[15,41,52,82],"variety":[17],"cells,":[19],"where":[20,95],"it":[21],"an":[23],"important":[24],"modulator":[25],"and":[26,47,78,191],"mediator":[27],"early":[29],"cell":[30],"adhesion":[31],"events.":[32],"This":[33],"layer":[35],"can":[36],"reach":[37],"5":[38],"mum":[39,51,106],"thickness":[40,107],"cells":[42,57],"that":[43],"produce":[44],"cartilage":[45],"(chondrocytes),":[46],"up":[48,103],"to":[49,72,104,128,154],"2":[50,105],"Xenopus":[53],"laevis":[54],"kidney":[55],"epithelial":[56],"(A6).":[58],"We":[59,87,178],"are":[60],"interested":[61],"in":[62,70],"generating":[63],"model":[64,93],"systems":[65,94],"for":[66,158],"order":[71],"learn":[73],"more":[74],"about":[75],"structure":[77],"function":[79],"biological":[83],"or":[84,176],"artificial":[85],"surfaces.":[86],"report":[88],"here":[89],"synthesis":[91],"coordinatively":[99],"cross-linked":[100],"was":[108,117],"covalently":[109],"photografted":[110],"onto":[111],"polystyrene":[112],"microspheres.":[113],"hydrated":[115],"imaged":[118],"directly":[119,179],"by":[120,147,195],"environmental":[121],"scanning":[122],"electron":[123],"microscopy":[124],"(ESEM)":[125],"at":[126],"close":[127],"100%":[129],"relative":[130],"humidity.":[131],"key":[133],"feature":[134],"procedure":[137],"reversible":[140],"reverse-temperature":[141],"phase":[142],"transition":[143],"induced":[146],"trivalent":[148],"lanthanide":[149,173],"cations,":[150],"which":[151],"exploited":[153],"achieve":[155],"sufficient":[156],"density":[157],"grafting":[159],"thick":[161],"layers.":[162],"microsphere-grafted":[164],"shows":[166],"temperature-dependent":[168],"swelling":[169],"when":[170],"labeled":[171],"with":[172,186],"ions":[174],"(Gd(3+)":[175],"Tb(3+)).":[177],"observed":[180],"volume":[182],"contraction":[183],"20%":[185],"increasing":[187],"temperature":[188],"between":[189],"1":[190],"11":[192],"degrees":[193],"C":[194],"wet-mode":[196],"ESEM.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
