{"id":"https://openalex.org/W2067348222","doi":"https://doi.org/10.1016/j.freeradbiomed.2005.03.014","title":"Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid","display_name":"Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid","publication_year":2005,"publication_date":"2005-04-07","ids":{"openalex":"https://openalex.org/W2067348222","doi":"https://doi.org/10.1016/j.freeradbiomed.2005.03.014","mag":"2067348222","pmid":"https://pubmed.ncbi.nlm.nih.gov/15964519"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2005.03.014","doi":"https://doi.org/10.1016/j.freeradbiomed.2005.03.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2005.03.014","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010572858","display_name":"Madia Trujillo","orcid":"https://orcid.org/0000-0003-2087-017X","observed_orcids":["https://orcid.org/0000-0003-2087-017X"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Madia Trujillo","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035221413","display_name":"Lisa K. Folkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lisa Folkes","raw_affiliation_strings":["Gray Cancer Institute, P.O. Box 100, Mount Vernon Hospital, Northwood, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gray Cancer Institute, P.O. Box 100, Mount Vernon Hospital, Northwood, Middlesex, UK","institution_ids":["https://openalex.org/I2801038905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037114307","display_name":"Silvina Bartesaghi","orcid":"https://orcid.org/0000-0002-7079-0795","observed_orcids":["https://orcid.org/0000-0002-7079-0795"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Silvina Bartesaghi","raw_affiliation_strings":["Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011165903","display_name":"Balaraman Kalyanaraman","orcid":"https://orcid.org/0000-0002-9180-8296","observed_orcids":["https://orcid.org/0000-0002-9180-8296"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balaraman Kalyanaraman","raw_affiliation_strings":["Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Research Institute and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033455586","display_name":"Peter Wardman","orcid":"https://orcid.org/0000-0002-9466-2245","observed_orcids":["https://orcid.org/0000-0002-9466-2245"]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Wardman","raw_affiliation_strings":["Gray Cancer Institute, P.O. Box 100, Mount Vernon Hospital, Northwood, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gray Cancer Institute, P.O. Box 100, Mount Vernon Hospital, Northwood, Middlesex, UK","institution_ids":["https://openalex.org/I2801038905"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073926538","display_name":"Rafael Rad\u00ed","orcid":"https://orcid.org/0000-0002-1114-1875","observed_orcids":["https://orcid.org/0000-0002-1114-1875"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Rafael Radi","raw_affiliation_strings":["Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073926538"],"corresponding_institution_ids":["https://openalex.org/I180910786"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":2.0734,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.85465116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"39","issue":"2","first_page":"279","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.32420000433921814,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.906000018119812},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dihydrolipoic-acid","display_name":"dihydrolipoic acid","score":1.0},{"id":"https://openalex.org/keywords/carbonate-radical","display_name":"carbonate radical","score":0.7390000224113464},{"id":"https://openalex.org/keywords/nitrogen-dioxide-radical","display_name":"nitrogen dioxide radical","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.4729999899864197},{"id":"https://openalex.org/keywords/glutathione-oxidation","display_name":"glutathione oxidation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/thiol-oxidation","display_name":"thiol oxidation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/radical-cation-formation","display_name":"radical cation formation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.9221435785293579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8036404848098755},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.7374169230461121},{"id":"https://openalex.org/C2780723490","wikidata":"https://www.wikidata.org/wiki/Q207895","display_name":"Nitrogen dioxide","level":2,"score":0.7350882291793823},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4782803952693939},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.4110136926174164},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.36916583776474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2525084316730499},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2508358955383301},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08503401279449463},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.06853702664375305}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002254","descriptor_name":"Carbonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008063","descriptor_name":"Thioctic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008063","descriptor_name":"Thioctic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009585","descriptor_name":"Nitrogen Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2005.03.014","doi":"https://doi.org/10.1016/j.freeradbiomed.2005.03.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2005.03.014","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:15964519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15964519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2242202778","display_name":"Nitric Oxide-Mediated Oxidation/Nitration in Membranes","funder_award_id":"R01HL063119","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W810637563","https://openalex.org/W943135624","https://openalex.org/W1532078988","https://openalex.org/W1580078772","https://openalex.org/W1829813323","https://openalex.org/W1964287788","https://openalex.org/W1964991169","https://openalex.org/W1965696818","https://openalex.org/W1967162316","https://openalex.org/W1967315269","https://openalex.org/W1967388554","https://openalex.org/W1968310022","https://openalex.org/W1971508454","https://openalex.org/W1972094880","https://openalex.org/W1972989329","https://openalex.org/W1975833075","https://openalex.org/W1976627375","https://openalex.org/W1976709363","https://openalex.org/W1977121598","https://openalex.org/W1977338190","https://openalex.org/W1977597523","https://openalex.org/W1978423213","https://openalex.org/W1979356762","https://openalex.org/W1981173052","https://openalex.org/W1985177004","https://openalex.org/W1987758728","https://openalex.org/W1994228161","https://openalex.org/W1996149774","https://openalex.org/W2006370393","https://openalex.org/W2006883146","https://openalex.org/W2012415015","https://openalex.org/W2018380711","https://openalex.org/W2020361903","https://openalex.org/W2022142673","https://openalex.org/W2022377100","https://openalex.org/W2032697293","https://openalex.org/W2035689722","https://openalex.org/W2036383883","https://openalex.org/W2037806971","https://openalex.org/W2038797702","https://openalex.org/W2039241150","https://openalex.org/W2048676468","https://openalex.org/W2049113108","https://openalex.org/W2051115462","https://openalex.org/W2051869971","https://openalex.org/W2054913058","https://openalex.org/W2058013605","https://openalex.org/W2059062053","https://openalex.org/W2059646723","https://openalex.org/W2061134483","https://openalex.org/W2064347448","https://openalex.org/W2064820284","https://openalex.org/W2066309385","https://openalex.org/W2066855036","https://openalex.org/W2067939107","https://openalex.org/W2068882989","https://openalex.org/W2069779383","https://openalex.org/W2070213990","https://openalex.org/W2076579924","https://openalex.org/W2077010993","https://openalex.org/W2077466344","https://openalex.org/W2079268420","https://openalex.org/W2080206499","https://openalex.org/W2082766301","https://openalex.org/W2086919008","https://openalex.org/W2094238895","https://openalex.org/W2097348569","https://openalex.org/W2098027823","https://openalex.org/W2110607710","https://openalex.org/W2122593933","https://openalex.org/W2137598362","https://openalex.org/W2150916538","https://openalex.org/W2152045883","https://openalex.org/W2329267027","https://openalex.org/W2604655513","https://openalex.org/W3134090442","https://openalex.org/W4248418451"],"related_works":["https://openalex.org/W2014442715","https://openalex.org/W2067939107","https://openalex.org/W2026104861","https://openalex.org/W2032697293","https://openalex.org/W2005947156","https://openalex.org/W2110607710","https://openalex.org/W1564875712","https://openalex.org/W1965961249","https://openalex.org/W1990171965","https://openalex.org/W2051115462"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}