{"id":"https://openalex.org/W2067280976","doi":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","title":"Gene targeting of a CFTR allele in HT29 human epithelial cells","display_name":"Gene targeting of a CFTR allele in HT29 human epithelial cells","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2067280976","doi":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","mag":"2067280976","pmid":"https://pubmed.ncbi.nlm.nih.gov/9066787"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","doi":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068146796","display_name":"Chahrzad Montrose\u2010Rafizadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chahrzad Montrose-Rafizadeh","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069227978","display_name":"Jolanta Kole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jolanta Kole","raw_affiliation_strings":["Department of Medicine, Duke University and Veterans Administration Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Duke University and Veterans Administration Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079400135","display_name":"L. Michele Bartkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Michele Bartkowski","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033401882","display_name":"Linda H. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda H. Lee","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063801402","display_name":"Denise L. Blackmon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise L. Blackmon","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063714259","display_name":"Sharon E. Behnken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon E. Behnken","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111897637","display_name":"John D. Gearhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Gearhart","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019953042","display_name":"Jonathan Allen Cohn","orcid":"https://orcid.org/0000-0001-8567-7034","observed_orcids":["https://orcid.org/0000-0001-8567-7034"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Cohn","raw_affiliation_strings":["Department of Medicine, Duke University and Veterans Administration Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Duke University and Veterans Administration Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063664853","display_name":"Marshall H. Montrose","orcid":"https://orcid.org/0000-0002-1847-0276","observed_orcids":["https://orcid.org/0000-0002-1847-0276"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marshall H. Montrose","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5063664853"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.22991526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"170","issue":"3","first_page":"299","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"cystic fibrosis transmembrane conductance regulator","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.8650000095367432},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8650000095367432},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/chloride-transport","display_name":"chloride transport","score":0.7599999904632568},{"id":"https://openalex.org/keywords/calcium-stimulation","display_name":"calcium stimulation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.714729905128479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5716105699539185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49656516313552856},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4865197539329529},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36594846844673157}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","doi":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.0.co;2-a","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.3.co;2-b","doi":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.3.co;2-b","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4652(199703)170:3<299::aid-jcp11>3.3.co;2-b","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:9066787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9066787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5162844073","display_name":null,"funder_award_id":"DK 40701","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8758555335","display_name":null,"funder_award_id":"DK44247","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W165204032","https://openalex.org/W1544426827","https://openalex.org/W1547481148","https://openalex.org/W1557739264","https://openalex.org/W1602619312","https://openalex.org/W1820036906","https://openalex.org/W1949252567","https://openalex.org/W1966912799","https://openalex.org/W1968578988","https://openalex.org/W1977188111","https://openalex.org/W1983426773","https://openalex.org/W1985771789","https://openalex.org/W1987325291","https://openalex.org/W1987760846","https://openalex.org/W1988727792","https://openalex.org/W1991115039","https://openalex.org/W1998776130","https://openalex.org/W2010309531","https://openalex.org/W2017612800","https://openalex.org/W2017615910","https://openalex.org/W2019099644","https://openalex.org/W2034721124","https://openalex.org/W2038611020","https://openalex.org/W2038701031","https://openalex.org/W2039599894","https://openalex.org/W2042273036","https://openalex.org/W2043502964","https://openalex.org/W2044594872","https://openalex.org/W2050573110","https://openalex.org/W2053090837","https://openalex.org/W2068710273","https://openalex.org/W2071093547","https://openalex.org/W2084619830","https://openalex.org/W2094306229","https://openalex.org/W2113300865","https://openalex.org/W2116365881","https://openalex.org/W2120428327","https://openalex.org/W2122862287","https://openalex.org/W2129391213","https://openalex.org/W2170265384","https://openalex.org/W2218329615","https://openalex.org/W2222376843","https://openalex.org/W2283679709","https://openalex.org/W2415252448","https://openalex.org/W2437546984","https://openalex.org/W4246131267"],"related_works":["https://openalex.org/W54158248","https://openalex.org/W2106612430","https://openalex.org/W2038611020","https://openalex.org/W2069289373","https://openalex.org/W1602619312","https://openalex.org/W2171467436","https://openalex.org/W2120428327","https://openalex.org/W1987325291","https://openalex.org/W2527850681","https://openalex.org/W2063251550"],"abstract_inverted_index":{"HT29":[0],"cells":[1],"endogenously":[2],"express":[3],"the":[4,41,59,111,134,141],"cystic":[5],"fibrosis":[6],"transmembrane":[7],"conductance":[8],"regulator":[9],"(CFTR)":[10],"and":[11,26,96,118],"have":[12],"been":[13,33],"used":[14,34],"previously":[15],"as":[16],"a":[17,49,76],"model":[18],"to":[19,35,172],"examine":[20],"cellular":[21,175],"regulation":[22,166],"of":[23,48,58,72,136,155,167,174],"CFTR":[24,38,50,64,85,105,129,139,168],"expression":[25],"chloride":[27,156,176],"secretory":[28],"function.":[29,178],"Homologous":[30],"recombination":[31],"has":[32,83],"specifically":[36],"disrupt":[37],"transcription":[39],"in":[40,104,110,127,138,149],"HT29-18-C1":[42],"subclone.":[43],"Experiments":[44],"demonstrate":[45,147],"successful":[46],"disruption":[47],"allele":[51,74],"by":[52,91,115],"DNA":[53],"constructs,":[54],"which":[55],"target":[56],"insertion":[57],"neomycin":[60],"phosphotransferase":[61],"gene":[62],"into":[63],"exon":[65],"1":[66],"via":[67],"homologous":[68],"recombination.":[69],"The":[70,87],"mutation":[71,88],"one":[73],"is":[75,89,108],"partial":[77,142],"knockout":[78,143],"because":[79],"this":[80],"cell":[81,113],"line":[82,114],"multiple":[84],"alleles.":[86],"confirmed":[90],"polymerase":[92],"chain":[93],"reaction":[94],"(PCR)":[95],"genomic":[97],"Southern":[98],"blot":[99],"analysis.":[100,120],"A":[101],"52-68%":[102],"reduction":[103,137],"mRNA":[106],"levels":[107,169],"observed":[109],"mutant":[112,144],"both":[116],"Northern":[117],"PCR":[119],"However,":[121],"Western":[122],"blots":[123],"show":[124],"no":[125],"decrease":[126],"total":[128],"protein":[130],"levels.":[131],"Consistent":[132],"with":[133],"lack":[135],"protein,":[140],"does":[145],"not":[146],"alterations":[148],"cyclic":[150],"AMP":[151],"or":[152,158],"calcium":[153],"stimulation":[154],"efflux":[157],"net":[159],"osmolyte":[160],"loss.":[161],"Results":[162],"suggest":[163],"that":[164],"posttranscriptional":[165],"may":[170],"contribute":[171],"maintenance":[173],"transport":[177]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
