{"id":"https://openalex.org/W2067212974","doi":"https://doi.org/10.1074/jbc.m003937200","title":"Mechanism of Phosphorylation of Protein Kinase B/Akt by a Constitutively Active 3-Phosphoinositide-dependent Protein Kinase-1","display_name":"Mechanism of Phosphorylation of Protein Kinase B/Akt by a Constitutively Active 3-Phosphoinositide-dependent Protein Kinase-1","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2067212974","doi":"https://doi.org/10.1074/jbc.m003937200","mag":"2067212974","pmid":"https://pubmed.ncbi.nlm.nih.gov/11006271"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m003937200","doi":"https://doi.org/10.1074/jbc.m003937200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m003937200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m003937200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016675333","display_name":"Michael J. Wick","orcid":"https://orcid.org/0000-0001-5683-8687","observed_orcids":["https://orcid.org/0000-0001-5683-8687"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Wick","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA","Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037831264","display_name":"Lily Dong","orcid":"https://orcid.org/0000-0002-6293-818X","observed_orcids":["https://orcid.org/0000-0002-6293-818X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Q. Dong","raw_affiliation_strings":["Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049095654","display_name":"Ramon A. Riojas","orcid":"https://orcid.org/0000-0002-5486-6243","observed_orcids":["https://orcid.org/0000-0002-5486-6243"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramon A. Riojas","raw_affiliation_strings":["Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039323940","display_name":"Fresnida J. Ramos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fresnida J. Ramos","raw_affiliation_strings":["Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100415272","display_name":"Feng Liu","orcid":"https://orcid.org/0000-0002-4442-7028","observed_orcids":["https://orcid.org/0000-0002-4442-7028"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng Liu","raw_affiliation_strings":["Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100415272"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.3692,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.92943751,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"275","issue":"51","first_page":"40400","last_page":"40406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6159999966621399},{"id":"https://openalex.org/keywords/pdpk1","display_name":"PDPK1","score":0.921999990940094},{"id":"https://openalex.org/keywords/pdk1","display_name":"PDK1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ser473-phosphorylation","display_name":"Ser473 phosphorylation","score":0.878000020980835},{"id":"https://openalex.org/keywords/ph-domain","display_name":"pleckstrin homology domain","score":0.9819999933242798},{"id":"https://openalex.org/keywords/prk2","display_name":"PRK2","score":0.996999979019165},{"id":"https://openalex.org/keywords/c2-ceramide","display_name":"C2-ceramide","score":0.7749999761581421},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.6439999938011169},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C49658373","wikidata":"https://www.wikidata.org/wiki/Q24776397","display_name":"Pleckstrin homology domain","level":3,"score":0.7364112734794617},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7182565331459045},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.6579031944274902},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6299130916595459},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.48299896717071533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47050637006759644},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4562874436378479},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4072864353656769},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3953990936279297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35083091259002686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35058704018592834}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064413","descriptor_name":"3-Phosphoinositide-Dependent Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m003937200","doi":"https://doi.org/10.1074/jbc.m003937200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m003937200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11006271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11006271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m003937200","doi":"https://doi.org/10.1074/jbc.m003937200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m003937200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3458824706","display_name":null,"funder_award_id":"DK-56166","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5458051969","display_name":"MECHANISMS AND ROLES OF PDK1 IN INSULIN SIGNALING","funder_award_id":"R01DK056166","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W89084389","https://openalex.org/W1791888878","https://openalex.org/W1965602524","https://openalex.org/W1974241409","https://openalex.org/W1974530349","https://openalex.org/W1975448725","https://openalex.org/W1990841830","https://openalex.org/W1999163644","https://openalex.org/W2002419494","https://openalex.org/W2005023357","https://openalex.org/W2030720692","https://openalex.org/W2039193709","https://openalex.org/W2047287528","https://openalex.org/W2047623534","https://openalex.org/W2059034341","https://openalex.org/W2059692699","https://openalex.org/W2061171666","https://openalex.org/W2064242629","https://openalex.org/W2065652048","https://openalex.org/W2074860444","https://openalex.org/W2103031848","https://openalex.org/W2103941658","https://openalex.org/W2105347265","https://openalex.org/W2120138780","https://openalex.org/W2129755293","https://openalex.org/W2144005841","https://openalex.org/W2146157811","https://openalex.org/W2166324877","https://openalex.org/W2167497319","https://openalex.org/W2888511473"],"related_works":["https://openalex.org/W2146157811","https://openalex.org/W2171218796","https://openalex.org/W2079123009","https://openalex.org/W2105347265","https://openalex.org/W1833083308","https://openalex.org/W2082770517","https://openalex.org/W2046264538","https://openalex.org/W2089617622","https://openalex.org/W1876033686","https://openalex.org/W2075725057"],"abstract_inverted_index":{"Phosphorylation":[0,73],"of":[1,25,37,42,74,83,87,93,99,106,131,154,165,169,175,222,238,253,261],"Thr(308)":[2,64,230,279],"in":[3,48,115,124,161,177,184,200,217,231,247,250,294],"the":[4,10,22,26,54,67,94,127,155,166,185,189,195,201,209,232,235,249,254,258,272],"activation":[5,221],"loop":[6],"and":[7,117,187,244,270,280,284],"Ser(473)":[8],"at":[9,63,147,188,229,277],"carboxyl":[11],"terminus":[12],"is":[13,224],"essential":[14],"for":[15],"protein":[16,45,133],"kinase":[17,134,287],"B":[18],"(PKB/Akt)":[19],"activation.":[20],"However,":[21,163,192],"biochemical":[23],"mechanism":[24],"phosphorylation":[27,62,114,174],"remains":[28],"to":[29,59,65,226,267,274],"be":[30,214],"characterized.":[31],"Here":[32],"we":[33],"show":[34],"that":[35,208],"expression":[36],"a":[38,102],"constitutively":[39,215],"active":[40,216],"mutant":[41],"mouse":[43],"3-phosphoinositide-dependent":[44],"kinase-1":[46,136],"(PDK1(A280V))":[47],"Chinese":[49],"hamster":[50],"ovary":[51],"cells":[52,84,116],"overexpressing":[53],"insulin":[55,71],"receptor":[56],"was":[57,78],"sufficient":[58,225],"induce":[60],"PKB":[61,75,107,113,143,176,228,276],"approximately":[66],"same":[68],"extent":[69],"as":[70],"stimulation.":[72],"by":[76,81,91],"PDK1(A280V)":[77,170,182,193],"not":[79,110,213],"affected":[80],"treatment":[82],"with":[85,150],"inhibitors":[86],"phosphatidylinositol":[88],"3-kinase":[89],"or":[90,138,152],"deletion":[92,153,164],"pleckstrin":[95],"homology":[96],"(PH)":[97],"domain":[98,157,168,197,237],"PKB.":[100],"C(2)-ceramide,":[101],"cell-permeable,":[103],"indirect":[104],"inhibitor":[105],"phosphorylation,":[108],"did":[109],"inhibit":[111],"PDK1(A280V)-catalyzed":[112],"had":[118],"no":[119],"effect":[120],"on":[121],"PDK1":[122,159,211,223,239,269],"activity":[123],"vitro.":[125,162],"On":[126],"other":[128],"hand,":[129],"co-expression":[130],"full-length":[132,282],"C-related":[135],"(PRK1/PKN)":[137],"2":[139],"(PRK2)":[140],"inhibited":[141],"PDK1(A280V)-mediated":[142,173],"phosphorylation.":[144],"Replacing":[145],"alanine":[146],"position":[148],"280":[149],"valine":[151],"PH":[156,167,196,236],"enhanced":[158],"autophosphorylation":[160],"significantly":[171],"reduced":[172],"cells.":[178,218],"In":[179,219],"resting":[180],"cells,":[181],"localized":[183,198],"cytosol":[186],"plasma":[190],"membrane.":[191],"lacking":[194],"predominantly":[199],"cytosol.":[202,233],"Taken":[203],"together,":[204],"our":[205],"findings":[206],"suggest":[207],"wild-type":[210],"may":[212,240,289],"addition,":[220],"phosphorylate":[227,275],"Furthermore,":[234],"play":[241,291],"both":[242,278,290],"positive":[243],"negative":[245,292],"roles":[246,293],"regulating":[248],"vivo":[251],"function":[252],"enzyme.":[255],"Finally,":[256],"unlike":[257],"carboxyl-terminal":[259],"fragment":[260],"PRK2,":[262],"which":[263],"has":[264],"been":[265],"shown":[266],"bind":[268],"allow":[271],"enzyme":[273],"Ser(473),":[281],"PRK2":[283],"its":[285],"related":[286],"PRK1/PKN":[288],"PKB-mediated":[295],"downstream":[296],"biological":[297],"events.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}