{"id":"https://openalex.org/W2067111141","doi":"https://doi.org/10.1158/1538-7445.am10-275","title":"Abstract 275: The shedding of epidermal growth factor receptor is mediated by MMP-2 or MMP-9 and stimulated by fibronectin in MDA-MB-468 cells","display_name":"Abstract 275: The shedding of epidermal growth factor receptor is mediated by MMP-2 or MMP-9 and stimulated by fibronectin in MDA-MB-468 cells","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2067111141","doi":"https://doi.org/10.1158/1538-7445.am10-275","mag":"2067111141"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-275","doi":"https://doi.org/10.1158/1538-7445.am10-275","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-275","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071627762","display_name":"Luis E. V\u00e1zquez-Qui\u00f1ones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55464072","display_name":"Universidad Metropolitana","ror":"https://ror.org/037gty358","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210159918","https://openalex.org/I55464072"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Luis E. Vazquez-Quinones","raw_affiliation_strings":["1Universidad Metropolitana-Cupey Campus, San Juan, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universidad Metropolitana-Cupey Campus, San Juan, PR","institution_ids":["https://openalex.org/I55464072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112826038","display_name":"Blanca L. Valle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Blanca L. Valle","raw_affiliation_strings":["2University of Puerto Rico, Medical Sciences Campus, San Juan, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Puerto Rico, Medical Sciences Campus, San Juan, PR","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035884995","display_name":"Krizia L. Cabrera-Toro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55464072","display_name":"Universidad Metropolitana","ror":"https://ror.org/037gty358","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210159918","https://openalex.org/I55464072"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Krizia L. Cabrera-Toro","raw_affiliation_strings":["1Universidad Metropolitana-Cupey Campus, San Juan, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universidad Metropolitana-Cupey Campus, San Juan, PR","institution_ids":["https://openalex.org/I55464072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097882458","display_name":"Sheila Torres-Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55464072","display_name":"Universidad Metropolitana","ror":"https://ror.org/037gty358","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210159918","https://openalex.org/I55464072"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Sheila Torres-Rodri\u0301guez","raw_affiliation_strings":["1Universidad Metropolitana-Cupey Campus, San Juan, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universidad Metropolitana-Cupey Campus, San Juan, PR","institution_ids":["https://openalex.org/I55464072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097964134","display_name":"Hazel Ozuna-V\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55464072","display_name":"Universidad Metropolitana","ror":"https://ror.org/037gty358","country_code":"PR","type":"education","lineage":["https://openalex.org/I4210159918","https://openalex.org/I55464072"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Hazel Ozuna-Va\u0301zquez","raw_affiliation_strings":["1Universidad Metropolitana-Cupey Campus, San Juan, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Universidad Metropolitana-Cupey Campus, San Juan, PR","institution_ids":["https://openalex.org/I55464072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012036174","display_name":"Marianela P\u00e9rez-Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Marianela Pe\u0301rez-Torres","raw_affiliation_strings":["2University of Puerto Rico, Medical Sciences Campus, San Juan, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Puerto Rico, Medical Sciences Campus, San Juan, PR","institution_ids":["https://openalex.org/I158818660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030907877","display_name":"Elsa M. Cora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Elsa M. Cora","raw_affiliation_strings":["2University of Puerto Rico, Medical Sciences Campus, San Juan, PR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Puerto Rico, Medical Sciences Campus, San Juan, PR","institution_ids":["https://openalex.org/I158818660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"275","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.1876000016927719,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.996999979019165},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mda-mb-468-cells","display_name":"MDA-MB-468","score":0.9340000152587891},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.47200000286102295},{"id":"https://openalex.org/keywords/erbb-signaling-pathway","display_name":"ErbB signaling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/serum-factors","display_name":"serum factors","score":0.4429999887943268},{"id":"https://openalex.org/keywords/metalloproteinase-inhibitors","display_name":"metalloproteinase inhibitors","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6657894253730774},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5859468579292297},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5207288861274719},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5122227072715759},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.5091227889060974},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.505924642086029},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4390954375267029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43588533997535706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4255378544330597},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.42470604181289673},{"id":"https://openalex.org/C2779404806","wikidata":"https://www.wikidata.org/wiki/Q488614","display_name":"Fetal bovine serum","level":3,"score":0.41992390155792236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4132533073425293},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28770941495895386},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.2659326195716858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2001459300518036}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-275","doi":"https://doi.org/10.1158/1538-7445.am10-275","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-275","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2908065771","https://openalex.org/W2007744599","https://openalex.org/W2222906468","https://openalex.org/W2337807589","https://openalex.org/W2063298867","https://openalex.org/W1985447634","https://openalex.org/W2315096726","https://openalex.org/W2761767525","https://openalex.org/W4231176579","https://openalex.org/W2010806829"],"abstract_inverted_index":{"Abstract":[0],"Activation":[1],"of":[2,32,38,52,60,73,77,83,92,102,109,137,145,161,205,231,253,284,296,307,312],"the":[3,19,39,66,74,78,93,114,135,143,162,195,203,229,251,273,282,308,313],"epidermal":[4],"growth":[5],"factor":[6],"receptor":[7,42,94,163],"(EGFR)":[8],"is":[9,87,120,286,295],"essential":[10],"for":[11,316],"cell":[12,48],"proliferation":[13],"and":[14,105,155,220,259,262,290,292],"tissue":[15],"homeostasis.":[16],"Alterations":[17],"in":[18,26,46,54,85,134,148,175,194,207,216,243,250],"ERBB":[20],"signaling":[21],"pathway":[22],"have":[23,43,126,222],"been":[24,44],"detected":[25],"several":[27,47],"human":[28],"cancers.":[29],"Soluble":[30],"isoforms":[31],"EGFR":[33,53,84,119,146,165,206,232,254,285],"generated":[34],"by":[35,89,106,255,288],"proteolytic":[36,115],"cleavage":[37,160,183],"membrane":[40,168],"bound":[41],"identified":[45],"lines.":[49],"The":[50,81],"shedding":[51,82,136,144,204,230,252,283],"MDA-MB-468":[55,86,149,171,208,240],"cells":[56,150,172,241],"generates":[57],"a":[58],"fragment":[59],"approximately":[61],"110":[62],"kDa":[63],"that":[64,117,128,142,228,281],"comprises":[65],"extracellular":[67],"domain":[68,76],"plus":[69],"four":[70],"amino":[71],"acids":[72],"transmembrane":[75],"full-length":[79],"receptor.":[80],"activated":[88,153,178],"two":[90],"ligands":[91],"(EGF,":[95],"TGF-alpha),":[96],"fetal":[97,199],"bovine":[98,200],"serum,":[99],"an":[100,107],"inhibitor":[101],"phosphatases":[103],"(pervanadate)":[104],"activator":[108],"metalloproteases":[110,130],"(i.e.":[111],"APMA).":[112],"However,":[113],"activity":[116],"cleaves":[118],"unknown.":[121],"Studies":[122],"using":[123],"metalloprotease":[124],"inhibitors":[125],"suggested":[127],"matrix":[129],"(MMPs)":[131],"are":[132],"involved":[133],"EGFR.":[138],"Here,":[139],"we":[140,158,210],"show":[141],"increased":[147,233],"treated":[151],"with":[152,177],"MMP-2":[154,179,189,289],"MMP-9.":[156,181],"Similarly,":[157],"observed":[159],"when":[164,186,234,265],"(Sigma)":[166,236],"or":[167,180,190],"preparations":[169],"from":[170],"were":[173,192],"incubated":[174],"vitro":[176],"This":[182,248],"was":[184,237,257,263,270],"blocked":[185],"antibodies":[187,266],"against":[188,267],"MMP-9":[191,291],"included":[193],"incubation":[196,274],"mixture.":[197],"Since":[198],"serum":[201,214,244],"increases":[202],"cells,":[209],"evaluated":[211],"whether":[212],"other":[213],"components":[215],"addition":[217],"to":[218,239,272],"EGF":[219],"TGF-alpha":[221],"similar":[223],"effect.":[224],"Our":[225],"results":[226,278],"showed":[227],"fibronectin":[235,256],"added":[238,271],"growing":[242],"free":[245],"culture":[246],"medium.":[247,275],"increase":[249],"dose":[258],"time":[260],"dependent":[261],"abolished":[264],"\u03b11\u03b25":[268],"integrin":[269],"Together,":[276],"these":[277],"strongly":[279],"suggest":[280],"mediated":[287],"therefore,":[293],"it":[294],"physiological":[297],"relevance.":[298],"Citation":[299],"Format:":[300],"{Authors}.":[301],"{Abstract":[302],"title}":[303],"[abstract].":[304],"In:":[305],"Proceedings":[306],"101st":[309],"Annual":[310],"Meeting":[311],"American":[314],"Association":[315],"Cancer":[317,327],"Research;":[318],"2010":[319],"Apr":[320],"17-21;":[321],"Washington,":[322],"DC.":[323],"Philadelphia":[324],"(PA):":[325],"AACR;":[326],"Res":[328],"2010;70(8":[329],"Suppl):Abstract":[330],"nr":[331],"275.":[332]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}