{"id":"https://openalex.org/W2067084553","doi":"https://doi.org/10.1117/12.2038561","title":"Photoinduced structural changes to protein kinase A","display_name":"Photoinduced structural changes to protein kinase A","publication_year":2014,"publication_date":"2014-03-13","ids":{"openalex":"https://openalex.org/W2067084553","doi":"https://doi.org/10.1117/12.2038561","mag":"2067084553"},"language":"en","primary_location":{"id":"doi:10.1117/12.2038561","doi":"https://doi.org/10.1117/12.2038561","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2038561","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031254680","display_name":"Sarah C. Rozinek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah C. Rozinek","raw_affiliation_strings":["Air Force Research Lab. (United States)","The Univ. of Texas at San Antonio (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Lab. (United States)","institution_ids":["https://openalex.org/I1280414376"]},{"raw_affiliation_string":"The Univ. of Texas at San Antonio (United States)","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619822","display_name":"Robert J. Thomas","orcid":"https://orcid.org/0000-0002-9754-6741","observed_orcids":["https://orcid.org/0000-0002-9754-6741"]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Thomas","raw_affiliation_strings":["Air Force Research Lab, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Lab, United States","institution_ids":["https://openalex.org/I1280414376"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037534302","display_name":"Lorenzo Brancaleon","orcid":"https://orcid.org/0000-0003-1039-339X","observed_orcids":["https://orcid.org/0000-0003-1039-339X"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo Brancaleon","raw_affiliation_strings":["The Univ. of Texas at San Antonio (United States)","The University of Texas at San Antonio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Texas at San Antonio (United States)","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"The University of Texas at San Antonio, United States","institution_ids":["https://openalex.org/I45438204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6014,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90952381,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8941","issue":null,"first_page":"89410T","last_page":"89410T"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.19460000097751617,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/porphyrins","display_name":"porphyrins","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.953000009059906},{"id":"https://openalex.org/keywords/meso-tetrakis-4-sulfonatophenyl-porphyrin","display_name":"meso-tetrakis(4-sulfonatophenyl)porphyrin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/photoinduced-structural-changes","display_name":"light-induced structural changes","score":0.6930000185966492},{"id":"https://openalex.org/keywords/non-covalent-protein-binding","display_name":"non-covalent protein binding","score":0.7710000276565552},{"id":"https://openalex.org/keywords/photoproduct-formation","display_name":"photoproduct formation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.6620000004768372},{"id":"https://openalex.org/keywords/fluorescence-lifetime","display_name":"fluorescence lifetime","score":0.6570000052452087},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cancer-phototherapy","display_name":"cancer phototherapy","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.67474365234375},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.645567774772644},{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.5443791747093201},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5210989713668823},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5105723142623901},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.47297611832618713},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4567930996417999},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4447915554046631},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4293730556964874},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.41696473956108093},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4151042103767395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32860076427459717},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.26567596197128296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24583783745765686},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.2358633279800415},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2038561","doi":"https://doi.org/10.1117/12.2038561","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2038561","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1664724705","https://openalex.org/W1964562243","https://openalex.org/W1966265565","https://openalex.org/W1976900284","https://openalex.org/W1979313879","https://openalex.org/W1987582475","https://openalex.org/W1996656968","https://openalex.org/W2033630329","https://openalex.org/W2033659449","https://openalex.org/W2046971384","https://openalex.org/W2059633603","https://openalex.org/W2129926159","https://openalex.org/W2137726644","https://openalex.org/W2323776360","https://openalex.org/W2571408655","https://openalex.org/W4238111560","https://openalex.org/W6732053210"],"related_works":["https://openalex.org/W1987582475","https://openalex.org/W2007879643","https://openalex.org/W1966265565","https://openalex.org/W310741661","https://openalex.org/W1970114319","https://openalex.org/W2248896541","https://openalex.org/W2129926159","https://openalex.org/W1676948079","https://openalex.org/W2485715242","https://openalex.org/W1587238216"],"abstract_inverted_index":{"The":[0],"importance":[1],"of":[2,52,67,95,124,134,148,156],"porphyrins":[3],"in":[4,48,83,92,151,166,186],"organisms":[5],"is":[6,32,162,215],"underscored":[7],"by":[8,18,22,131],"the":[9,33,84,93,122,132,173,239],"ubiquitous":[10],"biological":[11],"and":[12,21,26,37,50,99,154,169,176,190,197,219,221,242],"biochemical":[13],"functions":[14,128],"that":[15,61],"are":[16,129],"mediated":[17],"these":[19,183],"compounds":[20],"their":[23],"potential":[24],"biomedical":[25,39],"biotechnological":[27],"applications.":[28],"Protoporphyrin":[29],"IX":[30],"(PPIX)":[31],"precursor":[34],"to":[35,64,77,103,181,201,217],"heme":[36],"has":[38,59],"applications":[40],"such":[41],"as":[42,45],"its":[43],"use":[44],"a":[46,78,116,163],"photosensitizer":[47],"phototherapy":[49],"photodetection":[51],"cancer.":[53,125],"Among":[54],"other":[55,145],"applications,":[56],"our":[57],"group":[58],"demonstrated":[60],"low-irradiance":[62],"exposure":[63],"laser":[65],"irradiation":[66,229],"PPIX,":[68],"Fe-PPIX,":[69],"or":[70],"meso-tetrakis":[71],"(4-sulfonatophenyl)":[72],"porphyrin":[73,232],"(TSPP)":[74],"non-covalently":[75,199],"docked":[76],"protein":[79,96,106,112,119,174],"causes":[80],"conformational":[81],"changes":[82,227,236],"polypeptide.":[85],"Such":[86],"approach":[87],"can":[88,100],"have":[89,110],"remarkable":[90],"consequences":[91],"study":[94],"structure/function":[97],"relationship":[98],"be":[101],"used":[102],"prompt":[104],"non-native":[105],"properties.":[107],"Therefore":[108],"we":[109],"investigated":[111],"kinase":[113],"A":[114],"(PKA),":[115],"more":[117],"relevant":[118],"model":[120],"towards":[121],"photo-treatment":[123],"PKA\u2019s":[126],"enzymatic":[127,241],"regulated":[130],"presence":[133],"cyclic":[135],"adenosine":[136],"monophosphate":[137],"for":[138],"intracellular":[139],"signal":[140],"transduction":[141],"involved":[142],"in,":[143],"among":[144],"things,":[146],"stimulation":[147],"transcription,":[149],"tumorigenesis":[150],"Carney":[152],"complex":[153],"migration":[155],"breast":[157],"carcinoma":[158],"cells.":[159],"Since":[160],"phosphorylation":[161],"necessary":[164],"step":[165],"some":[167],"cancers":[168],"inflammatory":[170],"diseases,":[171],"inhibiting":[172],"kinase,":[175],"therefore":[177],"phosphorylation,":[178],"may":[179],"serve":[180],"treat":[182],"diseases.":[184],"Changes":[185],"absorption,":[187],"steady-state":[188],"fluorescence,":[189],"fluorescence":[191],"lifetime":[192],"indicate:":[193],"1)":[194],"both":[195],"TSPP":[196,218],"PPIX":[198],"bind":[200],"PKA":[202,214,223],"where":[203],"they":[204],"maintain":[205],"photoreactivity;":[206],"2)":[207],"absorptive":[208],"photoproduct":[209],"formation":[210],"occurs":[211],"only":[212],"when":[213],"bound":[216],"irradiated;":[220],"3)":[222],"undergoes":[224],"secondary":[225],"structural":[226],"after":[228],"with":[230],"either":[231],"bound.":[233],"These":[234],"photoinduced":[235],"could":[237],"affect":[238],"protein\u2019s":[240],"signaling":[243],"capabilities.":[244]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}