{"id":"https://openalex.org/W2066979009","doi":"https://doi.org/10.1007/s11325-013-0816-5","title":"Medical treatment with thiamine, coenzyme Q, vitamins E and C, and carnitine improved obstructive sleep apnea in an adult case of Leigh disease","display_name":"Medical treatment with thiamine, coenzyme Q, vitamins E and C, and carnitine improved obstructive sleep apnea in an adult case of Leigh disease","publication_year":2013,"publication_date":"2013-02-06","ids":{"openalex":"https://openalex.org/W2066979009","doi":"https://doi.org/10.1007/s11325-013-0816-5","mag":"2066979009","pmid":"https://pubmed.ncbi.nlm.nih.gov/23389837"},"language":"en","primary_location":{"id":"doi:10.1007/s11325-013-0816-5","doi":"https://doi.org/10.1007/s11325-013-0816-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11325-013-0816-5","pdf_url":null,"source":{"id":"https://openalex.org/S169018744","display_name":"Sleep And Breathing","issn_l":"1520-9512","issn":["1520-9512","1522-1709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep and Breathing","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055030084","display_name":"Charalampos M. Mermigkis","orcid":"https://orcid.org/0000-0003-1551-0743","observed_orcids":["https://orcid.org/0000-0003-1551-0743"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I4210138654","display_name":"University Hospital of Heraklion","ror":"https://ror.org/0312m2266","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210138654"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Charalampos Mermigkis","raw_affiliation_strings":["Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266","https://openalex.org/I4210138654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071091573","display_name":"Izolde Bouloukaki","orcid":"https://orcid.org/0000-0001-5903-3550","observed_orcids":["https://orcid.org/0000-0001-5903-3550"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I4210138654","display_name":"University Hospital of Heraklion","ror":"https://ror.org/0312m2266","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210138654"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Izolde Bouloukaki","raw_affiliation_strings":["Department of Respiratory Medicine, University of Crete, Heraklion, Crete, Greece","Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]},{"raw_affiliation_string":"Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266","https://openalex.org/I4210138654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005381448","display_name":"Vasileios C. Mastorodemos","orcid":"https://orcid.org/0000-0002-7397-2930","observed_orcids":["https://orcid.org/0000-0002-7397-2930"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasileios Mastorodemos","raw_affiliation_strings":["Neurology Department, School of Medicine, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, School of Medicine, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028475362","display_name":"Andreas Plaitakis","orcid":"https://orcid.org/0000-0002-3290-8254","observed_orcids":["https://orcid.org/0000-0002-3290-8254"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Andreas Plaitakis","raw_affiliation_strings":["Neurology Department, School of Medicine, University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, School of Medicine, University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005167554","display_name":"Vangelis Alogdianakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101420","display_name":"401 General Military Hospital of Athens","ror":"https://ror.org/01zy69h55","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210101420"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vangelis Alogdianakis","raw_affiliation_strings":["Sleep Disorders Center, 401 General Army Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Center, 401 General Army Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210101420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005370949","display_name":"Nikolaos Siafakas","orcid":"https://orcid.org/0000-0002-0088-143X","observed_orcids":["https://orcid.org/0000-0002-0088-143X"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I4210138654","display_name":"University Hospital of Heraklion","ror":"https://ror.org/0312m2266","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210138654"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Siafakas","raw_affiliation_strings":["Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266","https://openalex.org/I4210138654"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018085000","display_name":"Sophia E. Schiza","orcid":"https://orcid.org/0000-0002-0984-2584","observed_orcids":["https://orcid.org/0000-0002-0984-2584"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I4210138654","display_name":"University Hospital of Heraklion","ror":"https://ror.org/0312m2266","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210138654"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sophia Schiza","raw_affiliation_strings":["Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Unit, Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266","https://openalex.org/I4210138654"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071091573"],"corresponding_institution_ids":["https://openalex.org/I142617266","https://openalex.org/I4210138654"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.4847,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.80163094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"4","first_page":"1129","last_page":"1135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.8939999938011169},{"id":"https://openalex.org/keywords/leigh-syndrome","display_name":"Leigh syndrome","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.8529999852180481},{"id":"https://openalex.org/keywords/thiamine","display_name":"thiamine","score":0.906000018119812},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9369999766349792},{"id":"https://openalex.org/keywords/l-carnitine","display_name":"L-carnitine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":1.0},{"id":"https://openalex.org/keywords/continuous-positive-airway-pressure","display_name":"continuous positive airway pressure","score":0.968999981880188},{"id":"https://openalex.org/keywords/nocturnal-hypoxemia","display_name":"nocturnal hypoxemia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/polysomnography","display_name":"polysomnography","score":0.75}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8910224437713623},{"id":"https://openalex.org/C2776203871","wikidata":"https://www.wikidata.org/wiki/Q83187","display_name":"Thiamine","level":2,"score":0.8127358555793762},{"id":"https://openalex.org/C2778461778","wikidata":"https://www.wikidata.org/wiki/Q1815019","display_name":"Leigh disease","level":4,"score":0.7576649188995361},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.6285291910171509},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.6270647048950195},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.6262317895889282},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5985104441642761},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5109052062034607},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.4917643368244171},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4655483663082123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44140681624412537},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.416583389043808},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3685009181499481},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07605352997779846},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007888","descriptor_name":"Leigh Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007888","descriptor_name":"Leigh Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009460","descriptor_name":"Neurologic Examination","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013831","descriptor_name":"Thiamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11325-013-0816-5","doi":"https://doi.org/10.1007/s11325-013-0816-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11325-013-0816-5","pdf_url":null,"source":{"id":"https://openalex.org/S169018744","display_name":"Sleep And Breathing","issn_l":"1520-9512","issn":["1520-9512","1522-1709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep and Breathing","raw_type":"journal-article"},{"id":"pmid:23389837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23389837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep & breathing = Schlaf & Atmung","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W165593017","https://openalex.org/W1966508677","https://openalex.org/W1978457352","https://openalex.org/W1991543280","https://openalex.org/W1996980926","https://openalex.org/W2000377444","https://openalex.org/W2000887899","https://openalex.org/W2002676779","https://openalex.org/W2020895962","https://openalex.org/W2027632652","https://openalex.org/W2030119754","https://openalex.org/W2074900740","https://openalex.org/W2093519447","https://openalex.org/W2118481757","https://openalex.org/W2149901817","https://openalex.org/W2150126641","https://openalex.org/W2154796932","https://openalex.org/W2326390002","https://openalex.org/W2412539870","https://openalex.org/W2433420411"],"related_works":["https://openalex.org/W4293473680","https://openalex.org/W2002676779","https://openalex.org/W165593017","https://openalex.org/W2000803576","https://openalex.org/W1983979554","https://openalex.org/W2074900740","https://openalex.org/W2401351368","https://openalex.org/W6263835","https://openalex.org/W2004433085","https://openalex.org/W2030164588"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}