{"id":"https://openalex.org/W2066975811","doi":"https://doi.org/10.1002/pros.20468","title":"Vitamin E succinate inhibits NF\u2010\u03baB and prevents the development of a metastatic phenotype in prostate cancer cells: Implications for chemoprevention","display_name":"Vitamin E succinate inhibits NF\u2010\u03baB and prevents the development of a metastatic phenotype in prostate cancer cells: Implications for chemoprevention","publication_year":2007,"publication_date":"2007-01-29","ids":{"openalex":"https://openalex.org/W2066975811","doi":"https://doi.org/10.1002/pros.20468","mag":"2066975811","pmid":"https://pubmed.ncbi.nlm.nih.gov/17262802"},"language":"en","primary_location":{"id":"doi:10.1002/pros.20468","doi":"https://doi.org/10.1002/pros.20468","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.20468","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007324648","display_name":"Paul L. Crispen","orcid":"https://orcid.org/0000-0002-3699-6183","observed_orcids":["https://orcid.org/0000-0002-3699-6183"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul L. Crispen","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, PA 19111, USA","Fox Chase Cancer Center, Philadelphia, PA 19111, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA 19111, USA#TAB#","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043554307","display_name":"Robert G. Uzzo","orcid":"https://orcid.org/0000-0003-2398-6530","observed_orcids":["https://orcid.org/0000-0003-2398-6530"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Uzzo","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005433549","display_name":"Konstantin V. Golovine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantin Golovine","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047243753","display_name":"Peter B. Makhov","orcid":"https://orcid.org/0000-0002-8257-4782","observed_orcids":["https://orcid.org/0000-0002-8257-4782"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Makhov","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063389942","display_name":"Alan S Pollack","orcid":"https://orcid.org/0000-0002-1801-2865","observed_orcids":["https://orcid.org/0000-0002-1801-2865"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Pollack","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049646055","display_name":"Eric Mark Horwitz","orcid":"https://orcid.org/0000-0003-2187-317X","observed_orcids":["https://orcid.org/0000-0003-2187-317X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Horwitz","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075320625","display_name":"Richard Evan Greenberg","orcid":"https://orcid.org/0000-0002-8609-1307","observed_orcids":["https://orcid.org/0000-0002-8609-1307"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Greenberg","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045634878","display_name":"Vladimir M. Kolenko","orcid":"https://orcid.org/0000-0001-9585-3361","observed_orcids":["https://orcid.org/0000-0001-9585-3361"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladimir M. Kolenko","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045634878"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":5.4993,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.95764546,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"67","issue":"6","first_page":"582","last_page":"590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-e-succinate","display_name":"vitamin E succinate","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.8460000157356262},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7630000114440918},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":1.0},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.6050000190734863},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7289999723434448},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9679999947547913},{"id":"https://openalex.org/keywords/vitamin-e-analogues","display_name":"vitamin E analogues","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.7164646983146667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6392455101013184},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6324520111083984},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6304376125335693},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5108213424682617},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.5034212470054626},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4336746037006378},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4297303557395935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40912166237831116},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36725300550460815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34663891792297363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3024134039878845},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.10840320587158203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06276693940162659}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024505","descriptor_name":"Tocopherols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pros.20468","doi":"https://doi.org/10.1002/pros.20468","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.20468","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:17262802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17262802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1656876647","https://openalex.org/W1866952059","https://openalex.org/W1968751935","https://openalex.org/W1971284419","https://openalex.org/W1977216892","https://openalex.org/W1978879532","https://openalex.org/W1989714939","https://openalex.org/W1997574274","https://openalex.org/W2003960290","https://openalex.org/W2025504025","https://openalex.org/W2033758838","https://openalex.org/W2033895529","https://openalex.org/W2034715465","https://openalex.org/W2035522858","https://openalex.org/W2040849712","https://openalex.org/W2042740706","https://openalex.org/W2043118554","https://openalex.org/W2046076918","https://openalex.org/W2054400088","https://openalex.org/W2075172606","https://openalex.org/W2080709087","https://openalex.org/W2081695376","https://openalex.org/W2084225704","https://openalex.org/W2102371064","https://openalex.org/W2103023842","https://openalex.org/W2107366352","https://openalex.org/W2109442232","https://openalex.org/W2110675408","https://openalex.org/W2111678604","https://openalex.org/W2126078036","https://openalex.org/W2126870038","https://openalex.org/W2129528814","https://openalex.org/W2132394330","https://openalex.org/W2133433434","https://openalex.org/W2137307414","https://openalex.org/W2139855905","https://openalex.org/W2145352933","https://openalex.org/W2147450860","https://openalex.org/W2158925122","https://openalex.org/W2171156883","https://openalex.org/W2314325548","https://openalex.org/W4249569517","https://openalex.org/W4313335080"],"related_works":["https://openalex.org/W2791503601","https://openalex.org/W2043905796","https://openalex.org/W2376568811","https://openalex.org/W2137307414","https://openalex.org/W2046076918","https://openalex.org/W2120048864","https://openalex.org/W2384596160","https://openalex.org/W2123501058","https://openalex.org/W14293397","https://openalex.org/W1582004331"],"abstract_inverted_index":{"BACKGROUND:":[0],"NF-kappaB":[1,29,82],"and":[2,10,26,30,45,92,98,105,117,120,139],"AP-1":[3,31,85],"transcriptional":[4],"factors":[5],"contribute":[6],"to":[7,62,64,125],"the":[8,17,58,112,141],"development":[9],"progression":[11],"of":[12,19,60,89,114,135,143],"prostate":[13,152],"malignancy":[14],"by":[15,35,42,50,57,71],"regulating":[16],"expression":[18,47,88,100,113],"genes":[20],"involved":[21],"in":[22,101],"proliferation,":[23],"apoptosis,":[24],"angiogenesis,":[25],"metastasis.":[27],"METHODS:":[28],"activities":[32],"were":[33,40],"examined":[34,49,56],"TransAm":[36],"assay.":[37],"Cytokines":[38],"levels":[39],"assessed":[41],"ELISA.":[43],"ICAM-1":[44,97],"gp130":[46,99],"was":[48,55,69],"flow":[51],"cytometry.":[52],"Cell":[53,67],"adhesion":[54],"ability":[59],"cells":[61,124],"adhere":[63],"fibronectin-coated":[65],"plates.":[66],"viability":[68],"determined":[70],"propidium":[72],"iodide":[73],"staining.":[74],"RESULTS:":[75],"Treatment":[76],"with":[77],"alpha-tocopherol":[78],"succinate":[79],"(VES)":[80],"inhibits":[81],"but":[83],"augments":[84],"activity,":[86],"reduces":[87],"IL-6,":[90],"IL-8,":[91],"VEGF,":[93],"suppresses":[94],"cell":[95],"adhesion,":[96],"androgen-independent":[102],"PC-3,":[103],"DU-145,":[104],"CA-HPV-10":[106],"cells.":[107],"VES":[108],"supplementation":[109],"also":[110],"decreases":[111],"anti-apoptotic":[115],"XIAP":[116],"Bcl-X(L)":[118],"proteins":[119],"sensitizes":[121],"androgen-dependent":[122],"LNCaP":[123],"androgen":[126],"deprivation.":[127],"CONCLUSIONS:":[128],"Our":[129],"findings":[130],"propose":[131],"a":[132],"potential":[133,148],"mechanism":[134],"VES-mediated":[136],"anti-tumor":[137],"activity":[138],"support":[140],"role":[142],"vitamin":[144],"E":[145],"analogs":[146],"as":[147],"chemopreventative":[149],"agents":[150],"against":[151],"cancer.":[153]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}