{"id":"https://openalex.org/W2066940449","doi":"https://doi.org/10.4103/1673-5374.133161","title":"Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury","display_name":"Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2066940449","doi":"https://doi.org/10.4103/1673-5374.133161","mag":"2066940449","pmid":"https://pubmed.ncbi.nlm.nih.gov/25206755","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146309"},"language":"en","primary_location":{"id":"doi:10.4103/1673-5374.133161","doi":"https://doi.org/10.4103/1673-5374.133161","is_oa":true,"landing_page_url":"https://doi.org/10.4103/1673-5374.133161","pdf_url":null,"source":{"id":"https://openalex.org/S80372421","display_name":"Neural Regeneration Research","issn_l":"1673-5374","issn":["1673-5374","1876-7958"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regeneration Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/1673-5374.133161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018870384","display_name":"Luigi Aloe","orcid":"https://orcid.org/0000-0002-9796-1283","observed_orcids":["https://orcid.org/0000-0002-9796-1283"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luigi Aloe","raw_affiliation_strings":["Cellular Biology and Neurobiology Institute, National Research Council (CNR), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Biology and Neurobiology Institute, National Research Council (CNR), Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Patrizia Bianchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizia Bianchi","raw_affiliation_strings":["Cellular Biology and Neurobiology Institute, National Research Council (CNR), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Biology and Neurobiology Institute, National Research Council (CNR), Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088150642","display_name":"Alberto de Bellis","orcid":"https://orcid.org/0000-0002-5484-1652","observed_orcids":["https://orcid.org/0000-0002-5484-1652"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto De Bellis","raw_affiliation_strings":["Maria Rosaria Maglione Foundation Onlus, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maria Rosaria Maglione Foundation Onlus, Napoli, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025572626","display_name":"Marzia Soligo","orcid":"https://orcid.org/0000-0002-1420-0914","observed_orcids":["https://orcid.org/0000-0002-1420-0914"]},"institutions":[{"id":"https://openalex.org/I4210133672","display_name":"Istituto di Farmacologia Traslazionale","ror":"https://ror.org/03ta8pf33","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133672","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzia Soligo","raw_affiliation_strings":["Intitute of Translational Pharmacology, National Research Council (CNR), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intitute of Translational Pharmacology, National Research Council (CNR), Rome, Italy","institution_ids":["https://openalex.org/I4210133672","https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113875868","display_name":"Maria Luisa Rocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"MariaLuisa Rocco","raw_affiliation_strings":["Cellular Biology and Neurobiology Institute, National Research Council (CNR), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Biology and Neurobiology Institute, National Research Council (CNR), Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018870384"],"corresponding_institution_ids":["https://openalex.org/I4210155236"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":1.4781,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81245219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"10","first_page":"1025","last_page":"1025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.46630001068115234,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9430000185966492},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.9399999976158142},{"id":"https://openalex.org/keywords/blood-brain-barrier-bypass","display_name":"blood-brain barrier bypass","score":0.9629999995231628},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.996999979019165},{"id":"https://openalex.org/keywords/nerve-growth-factor-receptor","display_name":"nerve growth factor receptor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/spinal-neurons","display_name":"spinal cord neurons","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8840000033378601},{"id":"https://openalex.org/keywords/locomotor-deficits","display_name":"locomotor deficits","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neurotrophic-factor-therapy","display_name":"neurotrophic therapy","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.8485095500946045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8336995840072632},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7854534387588501},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.7295171022415161},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6090437769889832},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5995920300483704},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5732561945915222},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4168859124183655},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2537391185760498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.202591210603714},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1983931064605713},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4103/1673-5374.133161","doi":"https://doi.org/10.4103/1673-5374.133161","is_oa":true,"landing_page_url":"https://doi.org/10.4103/1673-5374.133161","pdf_url":null,"source":{"id":"https://openalex.org/S80372421","display_name":"Neural Regeneration Research","issn_l":"1673-5374","issn":["1673-5374","1876-7958"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regeneration Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4146309","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146309","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},{"id":"pmid:25206755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25206755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural regeneration research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/850050","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/850050","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3141497363","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/88507X/201410/50174189.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542097","display_name":"\u4e2d\u56fd\u795e\u7ecf\u518d\u751f\u7814\u7a76\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u795e\u7ecf\u518d\u751f\u7814\u7a76\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.4103/1673-5374.133161","doi":"https://doi.org/10.4103/1673-5374.133161","is_oa":true,"landing_page_url":"https://doi.org/10.4103/1673-5374.133161","pdf_url":null,"source":{"id":"https://openalex.org/S80372421","display_name":"Neural Regeneration Research","issn_l":"1673-5374","issn":["1673-5374","1876-7958"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regeneration Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W25634190","https://openalex.org/W55408324","https://openalex.org/W132538436","https://openalex.org/W408021019","https://openalex.org/W1500510737","https://openalex.org/W1818574585","https://openalex.org/W1971021103","https://openalex.org/W1974215491","https://openalex.org/W1985309267","https://openalex.org/W1987902256","https://openalex.org/W1998467441","https://openalex.org/W1999550376","https://openalex.org/W2003116578","https://openalex.org/W2008820260","https://openalex.org/W2011874194","https://openalex.org/W2017537032","https://openalex.org/W2017546292","https://openalex.org/W2027243420","https://openalex.org/W2031757318","https://openalex.org/W2043279725","https://openalex.org/W2060446687","https://openalex.org/W2079747710","https://openalex.org/W2082394860","https://openalex.org/W2082563967","https://openalex.org/W2084152233","https://openalex.org/W2084275633","https://openalex.org/W2091926606","https://openalex.org/W2106464041","https://openalex.org/W2114179943","https://openalex.org/W2122945372","https://openalex.org/W2126216011","https://openalex.org/W2130949325","https://openalex.org/W2132374129","https://openalex.org/W2133966135","https://openalex.org/W2139565721","https://openalex.org/W2164632895"],"related_works":["https://openalex.org/W2789612681","https://openalex.org/W2953013176","https://openalex.org/W2027426650","https://openalex.org/W3082443111","https://openalex.org/W2363972960","https://openalex.org/W2047616000","https://openalex.org/W2392622751","https://openalex.org/W4409277574","https://openalex.org/W2392304635","https://openalex.org/W2347588132"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,34,39,75,82,98,114,128,167,176],"this":[3],"work":[4],"was":[5],"to":[6],"investigate":[7],"whether,":[8],"by":[9],"intranasal":[10,54,96,143],"administration,":[11],"the":[12,17,23,37,88,119,142,163,174],"nerve":[13,55,76,83,99,130,134,144,170,179],"growth":[14,56,77,84,100,131,135,145,171],"factor":[15,57,78,85,101,132,136,146,172],"bypasses":[16,147],"blood-brain":[18,148],"barrier":[19,149],"and":[20,27,48,79,124,133,150],"turns":[21],"over":[22],"spinal":[24,40,50,89,115,126,152,156,178],"cord":[25,41,51,90,116,153,157],"neurons":[26,154],"if":[28],"such":[29],"therapeutic":[30,165],"approach":[31],"could":[32],"be":[33],"value":[35],"in":[36,59,87,102,111,121,155],"treatment":[38,107],"injury.":[42,158],"Adult":[43],"Sprague-Dawley":[44],"rats":[45],"with":[46],"intact":[47],"injured":[49],"received":[52],"daily":[53,106],"administration":[58,97],"both":[60,129],"nostrils":[61],"for":[62,66,108,173],"1":[63],"day":[64],"or":[65],"3":[67,109],"consecutive":[68],"weeks.":[69],"We":[70],"found":[71],"an":[72],"increased":[73,125],"content":[74,127],"enhanced":[80],"expression":[81],"receptor":[86],"24":[91],"hours":[92],"after":[93],"a":[94,112],"single":[95],"healthy":[103],"rats,":[104],"while":[105],"weeks":[110],"model":[113],"injury":[117],"improved":[118],"deficits":[120],"locomotor":[122],"behaviour":[123],"receptors.":[137],"These":[138],"outcomes":[139],"suggest":[140,161],"that":[141],"affects":[151],"They":[159],"also":[160],"exploiting":[162],"possible":[164],"role":[166],"intranasally":[168],"delivered":[169],"neuroprotection":[175],"damaged":[177],"cells.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}