{"id":"https://openalex.org/W2066934895","doi":"https://doi.org/10.1152/jn.01045.2011","title":"Development of motor maps in rats and their modulation by experience","display_name":"Development of motor maps in rats and their modulation by experience","publication_year":2012,"publication_date":"2012-06-22","ids":{"openalex":"https://openalex.org/W2066934895","doi":"https://doi.org/10.1152/jn.01045.2011","mag":"2066934895","pmid":"https://pubmed.ncbi.nlm.nih.gov/22723681"},"language":"en","primary_location":{"id":"doi:10.1152/jn.01045.2011","doi":"https://doi.org/10.1152/jn.01045.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.01045.2011","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111961253","display_name":"Nicole A. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I4405260330","display_name":"Hotchkiss Brain Institute","ror":"https://ror.org/03k51z204","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309","https://openalex.org/I4405260330"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicole A. Young","raw_affiliation_strings":["Department of Psychology, University of Calgary, Calgary, Alberta, Canada; and","Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Calgary, Calgary, Alberta, Canada; and","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada;","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I4405260330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112692044","display_name":"Jennifer Vuong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I4405260330","display_name":"Hotchkiss Brain Institute","ror":"https://ror.org/03k51z204","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309","https://openalex.org/I4405260330"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jennifer Vuong","raw_affiliation_strings":["Department of Psychology, University of Calgary, Calgary, Alberta, Canada; and","Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Calgary, Calgary, Alberta, Canada; and","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada;","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I4405260330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016152795","display_name":"G. Campbell Teskey","orcid":"https://orcid.org/0000-0002-8462-355X","observed_orcids":["https://orcid.org/0000-0002-8462-355X"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I4405260330","display_name":"Hotchkiss Brain Institute","ror":"https://ror.org/03k51z204","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309","https://openalex.org/I4405260330"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"G. Campbell Teskey","raw_affiliation_strings":["Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada","Department of Psychology, University of Calgary, Calgary, Alberta, Canada; and","Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Department of Psychology, University of Calgary, Calgary, Alberta, Canada; and","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada;","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I4405260330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016152795"],"corresponding_institution_ids":["https://openalex.org/I168635309","https://openalex.org/I4405260330"],"apc_list":null,"apc_paid":null,"fwci":1.8377,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.83505558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"108","issue":"5","first_page":"1309","last_page":"1317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.22470000386238098,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motor-maps","display_name":"motor maps","score":0.9710000157356262},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.8330000042915344},{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cortical-reorganization","display_name":"cortical reorganization","score":0.5360000133514404},{"id":"https://openalex.org/keywords/gabaergic-inhibition","display_name":"GABAergic inhibition","score":0.7519999742507935},{"id":"https://openalex.org/keywords/layer-v","display_name":"layer V","score":0.7369999885559082},{"id":"https://openalex.org/keywords/intracortical-microstimulation","display_name":"intracortical microstimulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C2778646069","wikidata":"https://www.wikidata.org/wiki/Q5468632","display_name":"Forelimb","level":2,"score":0.8259357213973999},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.7271688580513},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.723371148109436},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.6273253560066223},{"id":"https://openalex.org/C2776599063","wikidata":"https://www.wikidata.org/wiki/Q5282244","display_name":"Disinhibition","level":2,"score":0.5709689855575562},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.50303715467453},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4378302991390228},{"id":"https://openalex.org/C2779188335","wikidata":"https://www.wikidata.org/wiki/Q412504","display_name":"Muscimol","level":4,"score":0.4282670319080353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34195151925086975},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.28791677951812744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2210817039012909},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.19172650575637817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19102907180786133},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12459394335746765}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001640","descriptor_name":"Bicuculline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005552","descriptor_name":"Forelimb","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005552","descriptor_name":"Forelimb","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058787","descriptor_name":"GABA-A Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jn.01045.2011","doi":"https://doi.org/10.1152/jn.01045.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.01045.2011","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmid:22723681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22723681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310537","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W120756201","https://openalex.org/W148261105","https://openalex.org/W225336562","https://openalex.org/W1488323730","https://openalex.org/W1490648339","https://openalex.org/W1500504256","https://openalex.org/W1515213083","https://openalex.org/W1542887880","https://openalex.org/W1543041220","https://openalex.org/W1587156225","https://openalex.org/W1588629441","https://openalex.org/W1631652290","https://openalex.org/W1670203749","https://openalex.org/W1696376591","https://openalex.org/W1781000532","https://openalex.org/W1963954856","https://openalex.org/W1967310529","https://openalex.org/W1968020625","https://openalex.org/W1968131916","https://openalex.org/W1971833246","https://openalex.org/W1973809002","https://openalex.org/W1974236821","https://openalex.org/W1977244966","https://openalex.org/W1991315618","https://openalex.org/W1992618627","https://openalex.org/W1994469944","https://openalex.org/W1996285727","https://openalex.org/W1998952451","https://openalex.org/W1999191144","https://openalex.org/W2006837481","https://openalex.org/W2011692453","https://openalex.org/W2011783150","https://openalex.org/W2013986270","https://openalex.org/W2019273642","https://openalex.org/W2024121985","https://openalex.org/W2025270165","https://openalex.org/W2029621075","https://openalex.org/W2032899196","https://openalex.org/W2036386442","https://openalex.org/W2039555083","https://openalex.org/W2040742860","https://openalex.org/W2043279727","https://openalex.org/W2044566228","https://openalex.org/W2046280505","https://openalex.org/W2047662887","https://openalex.org/W2050023754","https://openalex.org/W2051428511","https://openalex.org/W2054098425","https://openalex.org/W2055632258","https://openalex.org/W2059407399","https://openalex.org/W2073620725","https://openalex.org/W2075895603","https://openalex.org/W2076074044","https://openalex.org/W2076684258","https://openalex.org/W2078089259","https://openalex.org/W2081468651","https://openalex.org/W2082333529","https://openalex.org/W2082407289","https://openalex.org/W2084606805","https://openalex.org/W2087353800","https://openalex.org/W2090736342","https://openalex.org/W2091111411","https://openalex.org/W2102008265","https://openalex.org/W2103828059","https://openalex.org/W2106113974","https://openalex.org/W2106319887","https://openalex.org/W2109335291","https://openalex.org/W2109738819","https://openalex.org/W2111015528","https://openalex.org/W2120301129","https://openalex.org/W2120616138","https://openalex.org/W2129243568","https://openalex.org/W2129934770","https://openalex.org/W2134935725","https://openalex.org/W2140626683","https://openalex.org/W2143682319","https://openalex.org/W2148145881","https://openalex.org/W2154385999","https://openalex.org/W2155926433","https://openalex.org/W2158436381","https://openalex.org/W2168467995","https://openalex.org/W2176670145","https://openalex.org/W2218740349","https://openalex.org/W2288435114","https://openalex.org/W2313447995","https://openalex.org/W2334275515","https://openalex.org/W2526283397","https://openalex.org/W2883008620","https://openalex.org/W4362550248"],"related_works":["https://openalex.org/W1980764140","https://openalex.org/W2311655068","https://openalex.org/W1967310529","https://openalex.org/W1991315618","https://openalex.org/W1781000532","https://openalex.org/W2475286470","https://openalex.org/W4234751434","https://openalex.org/W2155926433","https://openalex.org/W2091111411","https://openalex.org/W286073356"],"abstract_inverted_index":{"While":[0],"a":[1],"substantial":[2],"literature":[3],"demonstrates":[4],"the":[5,27,81,100,194,224,227,234],"effect":[6],"of":[7,12,18,23,30,69,116,136,166,223,269],"differential":[8,24],"experience":[9,25,264],"on":[10,26,80,126,133,141,175,183,206,250],"development":[11,29,51],"mammalian":[13],"sensory":[14],"cortices":[15],"and":[16,52,72,119,144,152,169,210,247,260],"plasticity":[17],"adult":[19,101],"motor":[20,31,56,93,117,138,170,179,270],"cortex,":[21,137],"characterization":[22],"functional":[28],"cortex":[32,118],"is":[33],"meager.":[34],"We":[35],"first":[36,123],"determined":[37],"when":[38],"forelimb":[39],"movement":[40,156],"representations":[41,249],"(motor":[42],"maps)":[43],"could":[44,59],"be":[45,60],"detected":[46,125],"in":[47,64,147,172,186,193,199,215,219,226],"rats":[48],"during":[49,272],"postnatal":[50,127],"then":[53,145],"whether":[54],"their":[55],"map":[57,204,225,238],"expression":[58,268],"altered":[61],"with":[62],"rearing":[63],"an":[65,220],"enriched":[66,187],"environment":[67],"consisting":[68],"group":[70],"housing":[71,196],"novel":[73],"toys":[74],"or":[75],"skilled":[76,261],"learning":[77],"by":[78,109],"training":[79,214,263],"single":[82],"pellet":[83],"reaching":[84],"task.":[85],"All":[86],"offspring":[87],"had":[88,153,202],"high-resolution":[89],"intracortical":[90],"microstimulation":[91],"(ICMS)-derived":[92],"maps":[94,139,171,180,271],"using":[95],"methodologies":[96],"previously":[97],"optimized":[98],"for":[99],"rat.":[102],"First,":[103],"cortical":[104],"GABA-mediated":[105],"inhibition":[106],"was":[107,240],"depressed":[108],"bicuculline":[110,134],"infusion":[111],"directly":[112],"into":[113],"layer":[114],"V":[115],"ICMS-responsive":[120],"points":[121,168],"were":[122,181],"reliably":[124],"day":[128],"(PND)":[129],"13.":[130],"Without":[131],"relying":[132],"disinhibition":[135],"emerged":[140],"PND":[142,150,176,184,251],"35":[143],"increased":[146],"size":[148],"until":[149],"60":[151],"progressively":[154],"lower":[155],"thresholds.":[157],"Second,":[158],"environmental":[159,258],"enrichment":[160,259],"did":[161],"not":[162,231],"affect":[163],"initial":[164],"detection":[165],"responsive":[167],"non-bicuculline-treated":[173],"pups":[174,189,192,217],"35.":[177],"However,":[178],"larger":[182],"45":[185],"rat":[188,216],"relative":[190],"to":[191,233],"standard":[195],"condition.":[197],"Rats":[198],"both":[200,257],"conditions":[201],"similar":[203],"sizes":[205],"PNDs":[207],"60,":[208],"75,":[209],"90.":[211],"Third,":[212],"reach":[213,262],"resulted":[218],"internal":[221],"reorganization":[222,239],"hemisphere":[228],"contralateral,":[229],"but":[230],"ipsilateral,":[232],"trained":[235],"forelimb.":[236],"The":[237],"expressed":[241],"as":[242],"proportionately":[243],"more":[244],"distal":[245],"(digit":[246],"wrist)":[248],"45.":[252],"Our":[253],"data":[254],"indicate":[255],"that":[256],"can":[265],"differentially":[266],"modify":[267],"development.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}