{"id":"https://openalex.org/W2066909017","doi":"https://doi.org/10.1089/ars.2005.7.1486","title":"Bovine Retinal Pericytes Are Resistant to Glucose-Induced Oxidative Stress In Vitro","display_name":"Bovine Retinal Pericytes Are Resistant to Glucose-Induced Oxidative Stress In Vitro","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W2066909017","doi":"https://doi.org/10.1089/ars.2005.7.1486","mag":"2066909017","pmid":"https://pubmed.ncbi.nlm.nih.gov/16356112"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2005.7.1486","doi":"https://doi.org/10.1089/ars.2005.7.1486","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2005.7.1486","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108529844","display_name":"Carl\u2010David Agardh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl-David Agardh","raw_affiliation_strings":["Department of Endocrinology, University Hospital MAS, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, University Hospital MAS, Malm\u00f6, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074221799","display_name":"Bj\u00f6rn L. Hultberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Hultberg","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068181497","display_name":"Ramesh C. Nayak","orcid":"https://orcid.org/0000-0002-3206-8152","observed_orcids":["https://orcid.org/0000-0002-3206-8152"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh C. Nayak","raw_affiliation_strings":["Department of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073392741","display_name":"Pamela J. Farthing-Nayak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Farthing-Nayak","raw_affiliation_strings":["Department of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Arizona College of Medicine, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085379404","display_name":"Elisabet Agardh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabet Agardh","raw_affiliation_strings":["Department of Ophthalmology, University Hospital MAS, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University Hospital MAS, Malm\u00f6, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3047,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68206668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"11-12","first_page":"1486","last_page":"1493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-pericytes","display_name":"retinal pericytes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8360809087753296},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6842477321624756},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6427813768386841},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6224862337112427},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5603797435760498},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5556273460388184},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5522282123565674},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5521655082702637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4985077381134033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4956110715866089},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.46258923411369324},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.43862080574035645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4231295585632324},{"id":"https://openalex.org/C136502266","wikidata":"https://www.wikidata.org/wiki/Q7226667","display_name":"Polyol pathway","level":4,"score":0.41902098059654236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.258260041475296},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13808384537696838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12528476119041443},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020286","descriptor_name":"Pericytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020286","descriptor_name":"Pericytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1089/ars.2005.7.1486","doi":"https://doi.org/10.1089/ars.2005.7.1486","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2005.7.1486","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},{"id":"pmid:16356112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16356112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:70b535ef-c92a-4271-91ce-27b08c363340","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/148681","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1557-7716","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W188128768","https://openalex.org/W313018790","https://openalex.org/W1207588145","https://openalex.org/W1775749144","https://openalex.org/W1968484754","https://openalex.org/W1970453663","https://openalex.org/W1972101449","https://openalex.org/W1977855971","https://openalex.org/W1980710871","https://openalex.org/W1986440171","https://openalex.org/W1987298734","https://openalex.org/W1988939685","https://openalex.org/W1992689397","https://openalex.org/W1993956963","https://openalex.org/W1994678068","https://openalex.org/W1996492681","https://openalex.org/W2005767645","https://openalex.org/W2008770524","https://openalex.org/W2025732390","https://openalex.org/W2032988386","https://openalex.org/W2036664753","https://openalex.org/W2040804695","https://openalex.org/W2043180682","https://openalex.org/W2045932444","https://openalex.org/W2048707769","https://openalex.org/W2051147127","https://openalex.org/W2073687136","https://openalex.org/W2078068799","https://openalex.org/W2111045985","https://openalex.org/W2111217646","https://openalex.org/W2112017685","https://openalex.org/W2113419419","https://openalex.org/W2115337518","https://openalex.org/W2118232192","https://openalex.org/W2140794335","https://openalex.org/W2141764386","https://openalex.org/W2145803528","https://openalex.org/W2148214967","https://openalex.org/W2157478347","https://openalex.org/W2157495535","https://openalex.org/W2166568175","https://openalex.org/W2169061609","https://openalex.org/W2188846692","https://openalex.org/W2413166777","https://openalex.org/W2769264260","https://openalex.org/W4234433304","https://openalex.org/W4244181694","https://openalex.org/W4244456009"],"related_works":["https://openalex.org/W3029938356","https://openalex.org/W2027749737","https://openalex.org/W2959169404","https://openalex.org/W2791867199","https://openalex.org/W2023012198","https://openalex.org/W7009968020","https://openalex.org/W4210637450","https://openalex.org/W2017391549","https://openalex.org/W4285604440","https://openalex.org/W3032686866"],"abstract_inverted_index":{"Diabetic":[0],"retinopathy":[1],"is":[2,169],"a":[3],"sight-threatening":[4],"complication":[5],"of":[6,10,15,29,58,65,83,99,127,132,182],"diabetes,":[7],"and":[8,54,73,95,103],"loss":[9],"pericytes":[11,157],"represents":[12],"early":[13],"signs":[14,28],"its":[16],"development.":[17],"We":[18],"tested":[19],"the":[20,81,93,97,111],"hypothesis":[21],"that":[22,156,173],"high":[23,46,114],"glucose":[24,49,183],"levels":[25,50],"may":[26,176],"induce":[27],"oxidative":[30,59,84,161,174],"stress":[31,60,162,175],"in":[32,92,141,149,163],"cultured":[33],"bovine":[34,142,150],"retinal":[35,151],"pericytes.":[36,152],"Pericytes":[37],"were":[38,61],"exposed":[39],"to":[40,165],"either":[41],"normal":[42],"(5.5":[43],"mM)":[44,48],"or":[45,119,130],"(22":[47],"for":[51],"1,":[52],"3,":[53],"5":[55],"days.":[56],"Signs":[57],"measured":[62,88],"by":[63],"expression":[64,126],"copper/zinc":[66],"superoxide":[67,70],"dismutase,":[68,71],"manganese":[69],"catalase,":[72],"glutathione":[74,89],"peroxidase":[75],"using":[76],"real-time":[77],"RTPCR.":[78],"To":[79],"elucidate":[80],"role":[82],"stress,":[85],"we":[86],"also":[87],"(GSH)":[90],"concentration":[91],"cells":[94],"investigated":[96],"impact":[98],"thiol-reactive":[100,116],"metal":[101,117],"ions":[102],"hydrogen":[104],"peroxide":[105],"(H(2)O(2))":[106],"on":[107],"intracellular":[108],"GSH.":[109],"Despite":[110],"stimulation":[112],"with":[113],"glucose,":[115],"ions,":[118],"H(2)O(2),":[120],"there":[121],"was":[122,139],"no":[123],"clear":[124],"increased":[125,140],"antioxidant":[128],"enzymes":[129],"influence":[131],"GSH":[133],"levels.":[134],"Lipid":[135],"peroxidation":[136],"(malondialdehyde":[137],"level)":[138],"aortic":[143],"smooth":[144],"muscle":[145],"cells,":[146],"but":[147],"not":[148,159,170],"The":[153],"data":[154],"indicate":[155],"do":[158],"develop":[160],"response":[164],"hyperglycemia.":[166],"However,":[167],"it":[168],"definitively":[171],"excluded":[172],"occur":[177],"after":[178],"longer":[179],"time":[180],"periods":[181],"stimulation.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
