{"id":"https://openalex.org/W2066878376","doi":"https://doi.org/10.1093/infdis/164.4.765","title":"Detection of Infectious Immune Complexes in Human Immunodeficiency Virus Type 1 (DIV-l) Infections: Correlation with Plasma Viremia and CD4 Cell Counts","display_name":"Detection of Infectious Immune Complexes in Human Immunodeficiency Virus Type 1 (DIV-l) Infections: Correlation with Plasma Viremia and CD4 Cell Counts","publication_year":1991,"publication_date":"1991-10-01","ids":{"openalex":"https://openalex.org/W2066878376","doi":"https://doi.org/10.1093/infdis/164.4.765","mag":"2066878376","pmid":"https://pubmed.ncbi.nlm.nih.gov/1680137"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/164.4.765","doi":"https://doi.org/10.1093/infdis/164.4.765","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/164.4.765","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112362716","display_name":"Susan A. Fiscus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. A. Fiscus","raw_affiliation_strings":["Department of Microbiology, University of North Carolina, Chapel Hill 27599","Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of North Carolina, Chapel Hill 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022404726","display_name":"Ewa Wallmark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. B. Wallmark","raw_affiliation_strings":["Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083937115","display_name":"James D. Folds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. D. Folds","raw_affiliation_strings":["Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Fryer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Fryer","raw_affiliation_strings":["Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110940940","display_name":"Charles M. van der Horst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. M. van der Horst","raw_affiliation_strings":["Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology, Medicine, and Biostatistics, University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":0.9278,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.714057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"164","issue":"4","first_page":"765","last_page":"769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6790000200271606},{"id":"https://openalex.org/keywords/polyethylene-glycol-precipitation","display_name":"polyethylene glycol precipitation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/p24-antigen","display_name":"p24 antigen","score":0.9020000100135803},{"id":"https://openalex.org/keywords/plasma-viremia","display_name":"plasma viremia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.9139999747276306},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8579999804496765},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.5389999747276306},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.8009999990463257},{"id":"https://openalex.org/keywords/aids-pathogenesis","display_name":"AIDS pathogenesis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/antiretroviral-efficacy","display_name":"antiretroviral efficacy","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.8385469317436218},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7106941938400269},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6638847589492798},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6072008609771729},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5942040681838989},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5045264959335327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45441919565200806},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.43367907404899597}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000386","descriptor_name":"AIDS-Related Complex","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000386","descriptor_name":"AIDS-Related Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011232","descriptor_name":"Chemical Precipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014758","descriptor_name":"Viral Core Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015488","descriptor_name":"HIV Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/infdis/164.4.765","doi":"https://doi.org/10.1093/infdis/164.4.765","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/164.4.765","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:1680137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1680137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.898.4471","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.898.4471","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jid.oxfordjournals.org/content/164/4/765.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3928469182","display_name":"ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM FOR AIDS","funder_award_id":"U01AI025868","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W69301831","https://openalex.org/W1993400169","https://openalex.org/W1993457223","https://openalex.org/W1997819367","https://openalex.org/W2002447796","https://openalex.org/W2029777784","https://openalex.org/W2040066032","https://openalex.org/W2125753727","https://openalex.org/W2142997299","https://openalex.org/W2318770038","https://openalex.org/W2323021547","https://openalex.org/W2611591252"],"related_works":["https://openalex.org/W7097837675","https://openalex.org/W2090766440","https://openalex.org/W2125753727","https://openalex.org/W2043714241","https://openalex.org/W2323021547","https://openalex.org/W199939342","https://openalex.org/W2091946509","https://openalex.org/W2129528425","https://openalex.org/W2033385943","https://openalex.org/W7097199303"],"abstract_inverted_index":{"The":[0,108,127],"detection":[1,76],"of":[2,21,23,32,38,45,70,78,106,110,137],"infectious":[3,50],"immune":[4],"complexes":[5],"in":[6,28,100],"plasma":[7,39,60,62,97],"after":[8],"human":[9],"immunodeficiency":[10],"virus":[11],"(HIV)":[12],"infection":[13],"may":[14,26,132],"be":[15,133],"useful":[16,135],"as":[17],"a":[18,89,134],"surrogate":[19],"marker":[20],"progression":[22,105],"disease":[24],"and":[25,49,59,68,96,104,123,131,142],"help":[27],"understanding":[29],"the":[30,43,75,79,111,124],"pathogenesis":[31],"AIDS.":[33],"Polyethylene":[34],"glycol":[35],"(PEG)":[36],"precipitates":[37],"were":[40,53],"tested":[41],"for":[42],"presence":[44],"HIV":[46],"p24":[47,63,80,94,113,118],"antigen":[48,81,95,114,119],"virus.":[51],"Results":[52],"compared":[54],"with":[55],"data":[56],"from":[57,83],"cell":[58,66,102],"cultures,":[61],"antigen,":[64],"CD4":[65,101],"counts,":[67,103],"stage":[69],"disease.":[71,107],"PEG":[72],"precipitation":[73],"increased":[74],"rate":[77],"assay":[82,115,128],"38.3%":[84],"to":[85],"58.7%.":[86],"There":[87],"was":[88,121,129],"significant":[90],"correlation":[91],"between":[92],"precipitable":[93],"viremia,":[98],"changes":[99],"sensitivity":[109],"PEG-precipitable":[112],"versus":[116],"traditional":[117],"testing":[120],"59.0%":[122],"specificity":[125],"91.7%.":[126],"reproducible":[130],"determinant":[136],"viral":[138],"load,":[139],"clinical":[140],"progression,":[141],"antiretroviral":[143],"efficacy.":[144]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}