{"id":"https://openalex.org/W2066869167","doi":"https://doi.org/10.1002/pssa.200461101","title":"Immunoassays in a porous silicon interferometric biosensor combined with sensitive signal processing","display_name":"Immunoassays in a porous silicon interferometric biosensor combined with sensitive signal processing","publication_year":2005,"publication_date":"2005-05-23","ids":{"openalex":"https://openalex.org/W2066869167","doi":"https://doi.org/10.1002/pssa.200461101","mag":"2066869167"},"language":"en","primary_location":{"id":"doi:10.1002/pssa.200461101","doi":"https://doi.org/10.1002/pssa.200461101","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pssa.200461101","pdf_url":null,"source":{"id":"https://openalex.org/S4210228582","display_name":"physica status solidi (a)","issn_l":"0031-8965","issn":["0031-8965","1521-396X","1862-6300","1862-6319"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"physica status solidi (a)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051444934","display_name":"A.M. Tinsley-Bown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339065421","display_name":"Defence Science and Technology Laboratory","ror":"https://ror.org/04jswqb94","country_code":"GB","type":"government","lineage":["https://openalex.org/I1306956679","https://openalex.org/I1339065421","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Tinsley\u2010Bown","raw_affiliation_strings":["Dstl, Chemical and Biological Sciences, Salisbury, Wilts, SP4 0JQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dstl, Chemical and Biological Sciences, Salisbury, Wilts, SP4 0JQ, United Kingdom","institution_ids":["https://openalex.org/I1339065421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109434329","display_name":"Richard G. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. G. Smith","raw_affiliation_strings":["Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Hayward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173869447","display_name":"Qinetiq (United Kingdom)","ror":"https://ror.org/02f60yb64","country_code":"GB","type":"company","lineage":["https://openalex.org/I173869447"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Hayward","raw_affiliation_strings":["QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom","institution_ids":["https://openalex.org/I173869447"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. H. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173869447","display_name":"Qinetiq (United Kingdom)","ror":"https://ror.org/02f60yb64","country_code":"GB","type":"company","lineage":["https://openalex.org/I173869447"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. H. Anderson","raw_affiliation_strings":["QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom","institution_ids":["https://openalex.org/I173869447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009099626","display_name":"Lynne Koker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173869447","display_name":"Qinetiq (United Kingdom)","ror":"https://ror.org/02f60yb64","country_code":"GB","type":"company","lineage":["https://openalex.org/I173869447"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Koker","raw_affiliation_strings":["QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom","institution_ids":["https://openalex.org/I173869447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047080743","display_name":"A. Green","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173869447","display_name":"Qinetiq (United Kingdom)","ror":"https://ror.org/02f60yb64","country_code":"GB","type":"company","lineage":["https://openalex.org/I173869447"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Green","raw_affiliation_strings":["QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom","institution_ids":["https://openalex.org/I173869447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076902190","display_name":"R. Torrens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Torrens","raw_affiliation_strings":["Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A.\u2010S. Wilkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173869447","display_name":"Qinetiq (United Kingdom)","ror":"https://ror.org/02f60yb64","country_code":"GB","type":"company","lineage":["https://openalex.org/I173869447"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.\u2010S. Wilkinson","raw_affiliation_strings":["QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom","institution_ids":["https://openalex.org/I173869447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083748239","display_name":"Elaine A. Perkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339065421","display_name":"Defence Science and Technology Laboratory","ror":"https://ror.org/04jswqb94","country_code":"GB","type":"government","lineage":["https://openalex.org/I1306956679","https://openalex.org/I1339065421","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. A. Perkins","raw_affiliation_strings":["Dstl, Chemical and Biological Sciences, Salisbury, Wilts, SP4 0JQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dstl, Chemical and Biological Sciences, Salisbury, Wilts, SP4 0JQ, United Kingdom","institution_ids":["https://openalex.org/I1339065421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108531967","display_name":"D.J. Squirrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339065421","display_name":"Defence Science and Technology Laboratory","ror":"https://ror.org/04jswqb94","country_code":"GB","type":"government","lineage":["https://openalex.org/I1306956679","https://openalex.org/I1339065421","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. J. Squirrell","raw_affiliation_strings":["Dstl, Chemical and Biological Sciences, Salisbury, Wilts, SP4 0JQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dstl, Chemical and Biological Sciences, Salisbury, Wilts, SP4 0JQ, United Kingdom","institution_ids":["https://openalex.org/I1339065421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063142383","display_name":"Stephen Nicklin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Nicklin","raw_affiliation_strings":["Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025628254","display_name":"Alistair P. Hutchinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Hutchinson","raw_affiliation_strings":["Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dstl, Fort Halstead, Sevenoaks, Kent, TN14 7BP, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108274460","display_name":"Andrew J. Simons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173869447","display_name":"Qinetiq (United Kingdom)","ror":"https://ror.org/02f60yb64","country_code":"GB","type":"company","lineage":["https://openalex.org/I173869447"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. J. Simons","raw_affiliation_strings":["QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom","institution_ids":["https://openalex.org/I173869447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112781942","display_name":"Timothy I. Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173869447","display_name":"Qinetiq (United Kingdom)","ror":"https://ror.org/02f60yb64","country_code":"GB","type":"company","lineage":["https://openalex.org/I173869447"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"T. I. Cox","raw_affiliation_strings":["QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QinetiQ, Malvern Technology Centre, St Andrew's Road, Great Malvern, Worcestershire, WR14 3PS, United Kingdom","institution_ids":["https://openalex.org/I173869447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112781942"],"corresponding_institution_ids":["https://openalex.org/I173869447"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":2.1909,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87112525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"202","issue":"8","first_page":"1347","last_page":"1356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11169","display_name":"Silicon Nanostructures and Photoluminescence","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11169","display_name":"Silicon Nanostructures and Photoluminescence","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porous-silicon","display_name":"porous silicon","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interferometric-biosensor","display_name":"interferometric biosensor","score":0.949999988079071},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.8199999928474426},{"id":"https://openalex.org/keywords/horseradish-peroxidase-detection","display_name":"horseradish peroxidase detection","score":0.8960000276565552},{"id":"https://openalex.org/keywords/competitive-binding-assay","display_name":"competitive binding assay","score":0.5519999861717224},{"id":"https://openalex.org/keywords/trinitrotoluene-detection","display_name":"trinitrotoluene detection","score":0.8679999709129333},{"id":"https://openalex.org/keywords/spectral-reflectance","display_name":"spectral reflectance","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.7774957418441772},{"id":"https://openalex.org/C2776685891","wikidata":"https://www.wikidata.org/wiki/Q428660","display_name":"Porous silicon","level":3,"score":0.7586283087730408},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.7243297696113586},{"id":"https://openalex.org/C2777676563","wikidata":"https://www.wikidata.org/wiki/Q413665","display_name":"Horseradish peroxidase","level":3,"score":0.7126244902610779},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.6237231492996216},{"id":"https://openalex.org/C544956773","wikidata":"https://www.wikidata.org/wiki/Q670","display_name":"Silicon","level":2,"score":0.6077702641487122},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5912665128707886},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.5747171640396118},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.5277707576751709},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4894205629825592},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.46850305795669556},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3788219094276428},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2710455358028412},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08767330646514893},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/pssa.200461101","doi":"https://doi.org/10.1002/pssa.200461101","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pssa.200461101","pdf_url":null,"source":{"id":"https://openalex.org/S4210228582","display_name":"physica status solidi (a)","issn_l":"0031-8965","issn":["0031-8965","1521-396X","1862-6300","1862-6319"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"physica status solidi (a)","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1966946807","https://openalex.org/W1973021949","https://openalex.org/W1977060721","https://openalex.org/W1984054367","https://openalex.org/W1985261292","https://openalex.org/W2000018522","https://openalex.org/W2005484249","https://openalex.org/W2006346404","https://openalex.org/W2022087263","https://openalex.org/W2022322089","https://openalex.org/W2026988234","https://openalex.org/W2038777776","https://openalex.org/W2042321583","https://openalex.org/W2046358777","https://openalex.org/W2064791705","https://openalex.org/W2068105788","https://openalex.org/W2071340091","https://openalex.org/W2071767241","https://openalex.org/W2077497445","https://openalex.org/W2084205182","https://openalex.org/W2090284578","https://openalex.org/W2092208953","https://openalex.org/W2111099731","https://openalex.org/W2128894160","https://openalex.org/W2149099352","https://openalex.org/W2158231066","https://openalex.org/W4255060668"],"related_works":["https://openalex.org/W2769997258","https://openalex.org/W2051557173","https://openalex.org/W2750100861","https://openalex.org/W3191120429","https://openalex.org/W2107559761","https://openalex.org/W2015601228","https://openalex.org/W1980275830","https://openalex.org/W2074082459","https://openalex.org/W2549304654","https://openalex.org/W2019296416"],"abstract_inverted_index":{"Abstract":[0],"Orthogonal":[1],"subspace":[2],"signal":[3],"processing":[4],"algorithms":[5],"(OSPA)":[6],"have":[7],"been":[8,88,114],"developed":[9],"to":[10,20,33,101],"extract":[11],"the":[12,117],"optical":[13,44],"thickness":[14,45],"of":[15,36,39,55,57,63,74,93,119],"a":[16,34,47,58,70,91,106,120],"porous":[17,107],"silicon":[18,108],"layer":[19,71],"within":[21,69,105],"one":[22],"part":[23],"in":[24,43],"105":[25],"from":[26],"its":[27,98],"reflectivity":[28],"spectrum.":[29],"This":[30],"is":[31],"equivalent":[32],"limit":[35],"detection":[37,118],"(LOD)":[38],"\u223c40":[40],"pm":[41],"change":[42],"for":[46,116,137],"3":[48],"\u00b5m":[49],"thick":[50],"layer,":[51],"or":[52],"an":[53],"LOD":[54],"1/2000":[56],"monolayer":[59],"coverage":[60],"with":[61,72],"antibodies,":[62],"molecular":[64],"weight":[65],"160":[66],"k":[67],"Daltons,":[68],"pores":[73],"100":[75],"nm":[76],"diameter.":[77],"A":[78,110],"large":[79],"molecule":[80,122],"{horseradish":[81],"peroxidase":[82],"(HRP),":[83],"MWt":[84,128],"40":[85],"kDa}":[86],"has":[87,113],"detected":[89],"at":[90,131],"concentration":[92],"1":[94,148],"\u00b5g/ml":[95,149],"by":[96,141],"measuring":[97],"direct":[99],"binding":[100],"anti\u2010HRP":[102],"antibodies":[103],"immobilised":[104],"layer.":[109],"competitive":[111],"assay":[112],"demonstrated":[115],"small":[121],"{2,":[123],"4,":[124],"6":[125],"trinitrotoluene":[126],"(TNT),":[127],"227":[129],"Da}":[130],"10":[132],"\u00b5g/ml.":[133],"The":[134],"projected":[135],"LODs":[136],"HRP":[138],"and":[139,147],"TNT":[140],"these":[142],"assays":[143],"are":[144],"50":[145],"ng/ml":[146],"respectively.":[150],"(\u00a9":[151],"2005":[152],"WILEY\u2010VCH":[153],"Verlag":[154],"GmbH":[155],"&":[156],"Co.":[157],"KGaA,":[158],"Weinheim)":[159]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}