{"id":"https://openalex.org/W2066865727","doi":"https://doi.org/10.1002/cbdv.200790166","title":"Peptide Nucleic Acids and the Origin of Life","display_name":"Peptide Nucleic Acids and the Origin of Life","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2066865727","doi":"https://doi.org/10.1002/cbdv.200790166","mag":"2066865727","pmid":"https://pubmed.ncbi.nlm.nih.gov/17886856"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.200790166","doi":"https://doi.org/10.1002/cbdv.200790166","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.200790166","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113615438","display_name":"Peter Eigil Nielsen","orcid":"https://orcid.org/0000-0001-8771-330X","observed_orcids":["https://orcid.org/0000-0001-8771-330X","https://orcid.org/0000-0002-9172-0315"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Peter\u2005E. Nielsen","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, Blegdamsvej 3c, DK-2200 Copenhagen N. pen@imbg.ku.dk","Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, Blegdamsvej 3c, DK-2200 Copenhagen N"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, Blegdamsvej 3c, DK-2200 Copenhagen N. pen@imbg.ku.dk","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, Blegdamsvej 3c, DK-2200 Copenhagen N","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113615438"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.184,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.86243479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"4","issue":"9","first_page":"1996","last_page":"2002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-nucleic-acid","display_name":"peptide nucleic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.968999981880188},{"id":"https://openalex.org/keywords/prebiotic-chemistry","display_name":"prebiotic chemistry","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ligation","display_name":"ligation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/early-earth","display_name":"early Earth","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.8553779125213623},{"id":"https://openalex.org/C190161988","wikidata":"https://www.wikidata.org/wiki/Q231218","display_name":"Abiogenesis","level":2,"score":0.7852777242660522},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7267416715621948},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5778617858886719},{"id":"https://openalex.org/C2777343594","wikidata":"https://www.wikidata.org/wiki/Q412152","display_name":"Peptide nucleic acid","level":3,"score":0.576708197593689},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5623621344566345},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.546072781085968},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45737361907958984},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39628103375434875},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32082295417785645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19815585017204285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18399393558502197},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1617036759853363}],"mesh":[{"descriptor_ui":"D000069497","descriptor_name":"Origin of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/cbdv.200790166","doi":"https://doi.org/10.1002/cbdv.200790166","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.200790166","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},{"id":"pmid:17886856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17886856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/10a3bc5b-4277-4269-a56c-eda469b57956","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/10a3bc5b-4277-4269-a56c-eda469b57956","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nielsen, P E 2007, 'Peptide nucleic acids and the origin of life', Chemistry & Biodiversity, vol. 4, no. 9, pp. 1996-2002. https://doi.org/10.1002/cbdv.200790166","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/44839e30-20ec-11dd-bc23-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/44839e30-20ec-11dd-bc23-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nielsen, P E 2007, 'Peptide nucleic acids and the origin of life', Chemistry & Biodiversity, vol. 4, no. 9, pp. 1996-2002.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5e9db620-ad95-11de-bc73-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/5e9db620-ad95-11de-bc73-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nielsen , P E 2009 , Peptide Nucleic Acids and the Origin of Life . in P Herdewijn & M V Kisak\u00fcrek (eds) , In Origin of Life, Chemical Approach . Verlag Helvetica Chimica Acta, Z\u00fcrich; WILEY-VCH .","raw_type":"bookPart"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1964696746","https://openalex.org/W1969990203","https://openalex.org/W1975451609","https://openalex.org/W1984319638","https://openalex.org/W1984507739","https://openalex.org/W1988256049","https://openalex.org/W1991122925","https://openalex.org/W1992628494","https://openalex.org/W1995115284","https://openalex.org/W2006998980","https://openalex.org/W2017341012","https://openalex.org/W2019818589","https://openalex.org/W2043529057","https://openalex.org/W2050696280","https://openalex.org/W2054249920","https://openalex.org/W2066037521","https://openalex.org/W2076910779","https://openalex.org/W2086992005","https://openalex.org/W2092102437","https://openalex.org/W2133830966","https://openalex.org/W2164701497","https://openalex.org/W2165852483"],"related_works":["https://openalex.org/W1995115284","https://openalex.org/W1974427190","https://openalex.org/W4234906207","https://openalex.org/W1990020604","https://openalex.org/W1679223975","https://openalex.org/W4233889967","https://openalex.org/W2015525598","https://openalex.org/W2502709005","https://openalex.org/W2160966621","https://openalex.org/W1991122925"],"abstract_inverted_index":{"The":[0],"possibilities":[1,57],"of":[2,17,29,36,58,69],"pseudo-peptide-DNA":[3],"mimics":[4],"like":[5],"PNA":[6,60],"(peptide":[7],"nucleic":[8],"acid)":[9],"having":[10],"a":[11],"role":[12],"for":[13],"the":[14,27,42,49,56,67],"prebiotic":[15,72],"origin":[16],"life":[18],"prior":[19],"to":[20],"an":[21,70],"RNA":[22],"world":[23],"is":[24,75],"discussed":[25],"on":[26,41],"basis":[28],"literature":[30],"data":[31,54],"showing":[32],"that":[33],"this":[34],"type":[35],"molecules":[37],"might":[38],"have":[39],"formed":[40],"primitive":[43],"earth":[44],"(or":[45],"other":[46],"places":[47],"in":[48],"universe),":[50],"as":[51,53],"well":[52],"indicating":[55],"template-directed":[59],"chemical":[61],"replication":[62],"and":[63],"ligation.":[64],"In":[65],"particular,":[66],"merits":[68],"achiral":[71],"genetic":[73],"material":[74],"discussed.":[76]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}