{"id":"https://openalex.org/W2066807643","doi":"https://doi.org/10.1039/c3ob42512f","title":"A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds","display_name":"A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2066807643","doi":"https://doi.org/10.1039/c3ob42512f","mag":"2066807643","pmid":"https://pubmed.ncbi.nlm.nih.gov/24614952"},"language":"en","primary_location":{"id":"doi:10.1039/c3ob42512f","doi":"https://doi.org/10.1039/c3ob42512f","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3ob42512f","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078228903","display_name":"THOMAS N. JAMES","orcid":"https://orcid.org/0000-0002-9728-9482","observed_orcids":["https://orcid.org/0000-0002-9728-9482"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas James","raw_affiliation_strings":["Astbury Centre for Structural Molecular Biology","Leeds, UK","School of Chemistry","University of Leeds","Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","School of Chemistry, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds, UK","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Chemistry, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019415757","display_name":"Paul MacLellan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul MacLellan","raw_affiliation_strings":["Astbury Centre for Structural Molecular Biology","Leeds, UK","School of Chemistry","University of Leeds","Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","School of Chemistry, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds, UK","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Chemistry, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070112401","display_name":"George M. Burslem","orcid":"https://orcid.org/0000-0002-2812-983X","observed_orcids":["https://orcid.org/0000-0002-2812-983X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George M. Burslem","raw_affiliation_strings":["Astbury Centre for Structural Molecular Biology","Leeds, UK","School of Chemistry","University of Leeds","Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","School of Chemistry, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds, UK","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Chemistry, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053281079","display_name":"Iain D. Simpson","orcid":"https://orcid.org/0009-0005-0675-5206","observed_orcids":["https://orcid.org/0009-0005-0675-5206"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iain Simpson","raw_affiliation_strings":["AstraZeneca","Macclesfield, UK","AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]},{"raw_affiliation_string":"Macclesfield, UK","institution_ids":[]},{"raw_affiliation_string":"AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113625729","display_name":"Jennifer Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Andrew Grant","raw_affiliation_strings":["AstraZeneca","Macclesfield, UK","AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca","institution_ids":["https://openalex.org/I105036370"]},{"raw_affiliation_string":"Macclesfield, UK","institution_ids":[]},{"raw_affiliation_string":"AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057466026","display_name":"Stuart L. Warriner","orcid":"https://orcid.org/0000-0002-7589-6011","observed_orcids":["https://orcid.org/0000-0002-7589-6011"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart Warriner","raw_affiliation_strings":["Astbury Centre for Structural Molecular Biology","Leeds, UK","School of Chemistry","University of Leeds","Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","School of Chemistry, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds, UK","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Chemistry, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039217190","display_name":"Visuvanathar Sridharan","orcid":"https://orcid.org/0000-0001-6389-0432","observed_orcids":["https://orcid.org/0000-0001-6389-0432"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Visuvanathar Sridharan","raw_affiliation_strings":["Leeds, UK","School of Chemistry","University of Leeds","School of Chemistry, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds, UK","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Chemistry, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083512991","display_name":"Adam S. Nelson","orcid":"https://orcid.org/0000-0003-3886-363X","observed_orcids":["https://orcid.org/0000-0003-3886-363X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Adam Nelson","raw_affiliation_strings":["Astbury Centre for Structural Molecular Biology","Leeds, UK","School of Chemistry","University of Leeds","Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","School of Chemistry, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds, UK","institution_ids":[]},{"raw_affiliation_string":"School of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Leeds","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"School of Chemistry, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083512991"],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":null,"apc_paid":null,"fwci":2.8942,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.92169875,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"16","first_page":"2584","last_page":"2591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.46239998936653137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.46239998936653137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piperazine","display_name":"piperazine","score":0.9679999947547913},{"id":"https://openalex.org/keywords/1-4-diazepane","display_name":"1,4-diazepane","score":0.9369999766349792},{"id":"https://openalex.org/keywords/modular-synthesis","display_name":"modular synthesis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/cyclic-sulfamidates","display_name":"cyclic sulfamidates","score":0.8450000286102295},{"id":"https://openalex.org/keywords/heterocyclic-scaffolds","display_name":"heterocyclic scaffolds","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ring-fused-heterocycles","display_name":"ring-fused heterocycles","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2776201271","wikidata":"https://www.wikidata.org/wiki/Q409292","display_name":"Piperazine","level":2,"score":0.8931385278701782},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.855737566947937},{"id":"https://openalex.org/C2781375217","wikidata":"https://www.wikidata.org/wiki/Q731821","display_name":"Diazepine","level":3,"score":0.7749588489532471},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.657002866268158},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.6081589460372925},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5951998233795166},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3406250476837158},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32363325357437134},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21044301986694336},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07665899395942688}],"mesh":[{"descriptor_ui":"D000077489","descriptor_name":"Piperazine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/c3ob42512f","doi":"https://doi.org/10.1039/c3ob42512f","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3ob42512f","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},{"id":"pmid:24614952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24614952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:78649","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/78649/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6071967825","display_name":null,"funder_award_id":"1090344","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7504672491","display_name":"Realising lead-oriented synthesis","funder_award_id":"EP/J00894X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1975237431","https://openalex.org/W1975293246","https://openalex.org/W1978009405","https://openalex.org/W1994781879","https://openalex.org/W2009000921","https://openalex.org/W2009046773","https://openalex.org/W2014013286","https://openalex.org/W2015440656","https://openalex.org/W2027482274","https://openalex.org/W2032353075","https://openalex.org/W2050052973","https://openalex.org/W2062458432","https://openalex.org/W2074274985","https://openalex.org/W2077102194","https://openalex.org/W2141568333","https://openalex.org/W2151447036","https://openalex.org/W2168639502","https://openalex.org/W2169303530","https://openalex.org/W2197008132","https://openalex.org/W2317744264","https://openalex.org/W2949123070","https://openalex.org/W2950122838"],"related_works":["https://openalex.org/W2051501526","https://openalex.org/W2951249224","https://openalex.org/W1504550518","https://openalex.org/W7124858244","https://openalex.org/W3082578686","https://openalex.org/W2573621555","https://openalex.org/W2949718107","https://openalex.org/W2969469527","https://openalex.org/W2109351653","https://openalex.org/W7152436255"],"abstract_inverted_index":{"Piperazines":[0],"are":[1],"found":[2,131],"widely":[3],"in":[4,14,48,99,132],"commercially-available":[5],"compounds":[6],"and":[7,32,54,64,67,88],"bioactive":[8],"molecules":[9,122],"(including":[10],"many":[11],"drugs).":[12],"However,":[13],"the":[15,21,73,84,91,100],"vast":[16],"majority":[17],"of":[18,38,51,72,75,90,102,105],"these":[19,125],"molecules,":[20],"piperazine":[22],"ring":[23,85],"is":[24,33,46],"isolated":[25],"(i.e.":[26],"not":[27,34],"fused":[28],"to":[29,82],"another":[30],"ring)":[31],"substituted":[35],"on":[36,109,124],"any":[37],"its":[39],"carbon":[40],"atoms.":[41],"A":[42],"modular":[43],"synthetic":[44],"approach":[45,96],"described":[47],"which":[49],"combinations":[50,74],"cyclic":[52],"sulfamidate":[53],"hydroxy":[55],"sulfonamide":[56],"building":[57,76],"blocks":[58,77],"may":[59],"be":[60],"converted":[61],"into":[62],"piperazines":[63],"related":[65],"1,4-diazepine":[66],"1,5-diazocane":[68],"scaffolds.":[69,94],"By":[70],"variation":[71],"used,":[78],"it":[79],"was":[80,97,117],"possible":[81],"vary":[83],"size,":[86],"substitution":[87],"configuration":[89],"resulting":[92],"heterocyclic":[93,106],"The":[95],"exemplified":[98],"synthesis":[101],"a":[103],"range":[104],"scaffolds":[107,126],"that,":[108],"decoration,":[110],"would":[111,127],"target":[112],"lead-like":[113,120],"chemical":[114],"space.":[115],"It":[116],"demonstrated":[118],"that":[119],"small":[121],"based":[123],"likely":[128],"complement":[129],"those":[130],"large":[133],"compound":[134],"collections.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}