{"id":"https://openalex.org/W2066706367","doi":"https://doi.org/10.1096/fj.01-0844fje","title":"Purification and characterization of a cyclooxygenase\u20102 and angiogenesis suppressing factor produced by human fibroblasts","display_name":"Purification and characterization of a cyclooxygenase\u20102 and angiogenesis suppressing factor produced by human fibroblasts","publication_year":2002,"publication_date":"2002-06-07","ids":{"openalex":"https://openalex.org/W2066706367","doi":"https://doi.org/10.1096/fj.01-0844fje","mag":"2066706367","pmid":"https://pubmed.ncbi.nlm.nih.gov/12060668"},"language":"en","primary_location":{"id":"doi:10.1096/fj.01-0844fje","doi":"https://doi.org/10.1096/fj.01-0844fje","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.01-0844fje","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103153084","display_name":"Wuguo Deng","orcid":"https://orcid.org/0000-0002-1193-1500","observed_orcids":["https://orcid.org/0000-0002-1193-1500"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wu\u2010Guo Deng","raw_affiliation_strings":["Vascular Biology Research Center and Division of Hematology University of Texas-Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of Hematology University of Texas-Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael A. Saunders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Saunders","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024695885","display_name":"Derek William Gilroy","orcid":"https://orcid.org/0000-0003-3476-0844","observed_orcids":["https://orcid.org/0000-0003-3476-0844"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek W. Gilroy","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111797747","display_name":"Xue\u2010Zhong He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue\u2010Zhong He","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110774831","display_name":"Howard Yeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Yeh","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084126232","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0002-3813-7577","observed_orcids":["https://orcid.org/0000-0002-3813-7577"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017742334","display_name":"Mikhail I. Shtivelband","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikhail I. Shtivelband","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101539564","display_name":"Ke\u2010He Ruan","orcid":"https://orcid.org/0000-0001-7165-2231","observed_orcids":["https://orcid.org/0000-0001-7165-2231","https://orcid.org/0000-0001-7694-4452"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke\u2010He Ruan","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035975194","display_name":"Kenneth K. Wu","orcid":"https://orcid.org/0000-0003-2306-6320","observed_orcids":["https://orcid.org/0000-0003-2306-6320"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth K. Wu","raw_affiliation_strings":["Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Research Center and Division of HematologyUniversity of Texas\u2010Houston Medical School 6431 Fannin St. Houston Texas","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.1566,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.77801057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"10","first_page":"1286","last_page":"1288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7960000038146973},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.9120000004768372},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8050000071525574},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9570000171661377},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7268857359886169},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5843631029129028},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5767589807510376},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5458413362503052},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.508112907409668},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4785107672214508},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43931201100349426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4384177029132843},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4244217872619629},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42407214641571045},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4197397232055664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.403184711933136},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4014352560043335},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2437020242214203},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1605912446975708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14564013481140137},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10625949501991272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05568665266036987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1096/fj.01-0844fje","doi":"https://doi.org/10.1096/fj.01-0844fje","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.01-0844fje","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:12060668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12060668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:162897","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/162897/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"FASEB JOURNAL , 16 (8) 1286-+. (2002)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1553107571","https://openalex.org/W1598952686","https://openalex.org/W1976694956","https://openalex.org/W1989948125","https://openalex.org/W2011985807","https://openalex.org/W2037745595","https://openalex.org/W2043707891","https://openalex.org/W2056574134","https://openalex.org/W2077366814","https://openalex.org/W2083748640","https://openalex.org/W2097997344","https://openalex.org/W2117064945","https://openalex.org/W2127558096","https://openalex.org/W2149843008","https://openalex.org/W2158686638","https://openalex.org/W2165663767","https://openalex.org/W2170935967","https://openalex.org/W2272602062","https://openalex.org/W2338562269"],"related_works":["https://openalex.org/W2128370493","https://openalex.org/W2127558096","https://openalex.org/W2050658186","https://openalex.org/W2376107413","https://openalex.org/W2017929299","https://openalex.org/W2019386995","https://openalex.org/W2357493482","https://openalex.org/W1977363437","https://openalex.org/W2078422697","https://openalex.org/W2275199760"],"abstract_inverted_index":{"Cyclooxygenase-2":[0],"(COX-2)":[1],"is":[2,27,38],"an":[3,8,139],"inducible":[4],"enzyme":[5],"that":[6,24,56],"plays":[7],"important":[9],"role":[10],"in":[11,29,83,93,102],"several":[12],"pathophysiological":[13],"processes,":[14],"including":[15],"inflammation,":[16],"angiogenesis,":[17],"and":[18,45,80,85,90,97,115,123],"tumorigenesis.":[19],"We":[20],"have":[21],"recently":[22],"observed":[23],"COX-2":[25,58,67,87,109,136],"induction":[26],"restrained":[28],"proliferating":[30,52],"fibroblasts.":[31],"The":[32],"mechanism":[33],"by":[34,71,112,120,138],"which":[35,62],"this":[36],"occurs":[37],"unclear.":[39],"Here,":[40],"we":[41],"report":[42],"the":[43,48,133],"detection":[44],"isolation":[46],"from":[47],"conditioned":[49],"medium":[50],"of":[51,135],"fibroblasts":[53,84],"a":[54,103],"factor":[55,78],"suppressed":[57,66],"expression.":[59],"This":[60],"factor,":[61],"was":[63],"named":[64],"cytoguardin,":[65],"protein":[68,88],"levels":[69,89],"induced":[70,111,119],"phorbol":[72],"12-myristate":[73],"13-acetate,":[74],"interleukin-1beta,":[75],"tumor":[76],"necrosis":[77],"alpha,":[79],"lipopolysaccharide":[81],"(LPS)":[82],"LPS-induced":[86],"promoter":[91],"activities":[92],"human":[94],"endothelial":[95,116],"cells":[96,101],"murine":[98],"RAW":[99],"264.7":[100],"comparable":[104],"concentration-dependent":[105],"manner.":[106],"It":[107],"inhibited":[108],"expression":[110],"angiogenic":[113,121],"factors":[114,122],"tube":[117],"formation":[118],"colon":[124],"cancer":[125],"cell":[126],"medium.":[127],"These":[128],"findings":[129],"provide":[130],"evidence":[131],"for":[132],"control":[134],"transcription":[137],"endogenous":[140],"cellular":[141],"factor.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}