{"id":"https://openalex.org/W2066595407","doi":"https://doi.org/10.1002/gcc.2870040207","title":"Chromosomal abnormalities in skin following total body or total lymphoid irradiation","display_name":"Chromosomal abnormalities in skin following total body or total lymphoid irradiation","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2066595407","doi":"https://doi.org/10.1002/gcc.2870040207","mag":"2066595407","pmid":"https://pubmed.ncbi.nlm.nih.gov/1373314"},"language":"en","primary_location":{"id":"doi:10.1002/gcc.2870040207","doi":"https://doi.org/10.1002/gcc.2870040207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.2870040207","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Charles M. Rubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles M. Rubin","raw_affiliation_strings":["Department of Pediatrics, University of Chicago, Illinois 60637","Departments of Pediatrics and Medicine, University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Departments of Pediatrics and Medicine, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108204618","display_name":"Mark E. Nesbit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Nesbit","raw_affiliation_strings":["Departments of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103483889","display_name":"John H. Kersey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Kersey","raw_affiliation_strings":["Departments of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","Laboratory Medicine and Pathology, University of Minnesota Health Sciences Center, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Laboratory Medicine and Pathology, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110480067","display_name":"Diane C. Arthur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane C. Arthur","raw_affiliation_strings":["Departments of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","Laboratory Medicine and Pathology, University of Minnesota Health Sciences Center, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Laboratory Medicine and Pathology, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111797445","display_name":"Tae H. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae H. Kim","raw_affiliation_strings":["Therapeutic Radiology, University of Minnesota Health Sciences Center, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Therapeutic Radiology, University of Minnesota Health Sciences Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":4810,"currency":"USD","value_usd":4810},"apc_paid":null,"fwci":0.4289,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67016652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"4","issue":"2","first_page":"141","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/total-lymphoid-irradiation","display_name":"total lymphoid irradiation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.7870000004768372},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8569999933242798},{"id":"https://openalex.org/keywords/radiation-induced-chromosome-damage","display_name":"radiation-induced chromosome damage","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8970000147819519},{"id":"https://openalex.org/keywords/reciprocal-translocation","display_name":"reciprocal translocation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pseudodiploidy","display_name":"pseudodiploidy","score":0.859000027179718},{"id":"https://openalex.org/keywords/balanced-chromosomal-rearrangements","display_name":"balanced chromosomal rearrangements","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2778880498","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Total body irradiation","level":4,"score":0.7273476123809814},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.605394721031189},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42358726263046265},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.42277389764785767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36179977655410767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3279288709163666},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3240931034088135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19977092742919922},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13244342803955078},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002877","descriptor_name":"Chromosomes, Human","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015182","descriptor_name":"Lymphatic Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/gcc.2870040207","doi":"https://doi.org/10.1002/gcc.2870040207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.2870040207","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},{"id":"pmid:1373314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1373314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, chromosomes & cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1459631563","display_name":"PEDIATRIC ONCOLOGY TRAINING PROGRAM","funder_award_id":"5t32ca009445-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G334838614","display_name":null,"funder_award_id":"CA-09445","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G369841689","display_name":null,"funder_award_id":"CA-07306","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4652448307","display_name":"CHILDRENS CANCER GROUP","funder_award_id":"U10CA007306","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W33382804","https://openalex.org/W102159569","https://openalex.org/W160421758","https://openalex.org/W204358444","https://openalex.org/W1561271362","https://openalex.org/W1564690801","https://openalex.org/W1565341627","https://openalex.org/W1602425842","https://openalex.org/W1796305773","https://openalex.org/W1967897710","https://openalex.org/W1980356048","https://openalex.org/W2006194587","https://openalex.org/W2007532842","https://openalex.org/W2007684414","https://openalex.org/W2012599973","https://openalex.org/W2015212822","https://openalex.org/W2027311333","https://openalex.org/W2050123375","https://openalex.org/W2057816695","https://openalex.org/W2070449707","https://openalex.org/W2075618985","https://openalex.org/W2083492673","https://openalex.org/W2090300685","https://openalex.org/W2091584629","https://openalex.org/W2092701238","https://openalex.org/W2105898257","https://openalex.org/W2129464819","https://openalex.org/W2138253675","https://openalex.org/W2250049252","https://openalex.org/W2342320434","https://openalex.org/W2412436505","https://openalex.org/W2418454756","https://openalex.org/W3148848738"],"related_works":["https://openalex.org/W2206549014","https://openalex.org/W6887568756","https://openalex.org/W3217497349","https://openalex.org/W2588565554","https://openalex.org/W7097661632","https://openalex.org/W2073007028","https://openalex.org/W1970211228","https://openalex.org/W2006194587","https://openalex.org/W2050123375","https://openalex.org/W1537376384"],"abstract_inverted_index":{"Patients":[0],"undergoing":[1],"bone":[2,169],"marrow":[3,21,170],"transplantation":[4,171],"often":[5],"receive":[6],"total":[7,10,60],"body":[8,61],"or":[9,110],"lymphoid":[11,83,127],"irradiation":[12],"as":[13],"part":[14],"of":[15,26,75,120,154],"the":[16,72,108,111,126,165],"conditioning":[17],"regimen":[18],"prior":[19],"to":[20],"infusion.":[22],"The":[23,161],"cytogenetic":[24],"effects":[25],"this":[27],"therapy":[28],"on":[29],"skin":[30,38,124,180],"fibroblasts":[31],"were":[32,40,51,105,130,142,147,158],"studied.":[33],"Fibroblast":[34],"cultures":[35],"from":[36,52,65,70,87,98,123,136],"eight":[37],"biopsies":[39,50,138],"harvested":[41],"in":[42,107,177,179],"early":[43],"passages":[44],"for":[45,168],"G-banded":[46],"chromosome":[47,175],"analysis.":[48],"Four":[49],"three":[53],"patients":[54],"who":[55,78,90,113],"had":[56,79,91,114],"high-dose":[57,80],"cyclophosphamide":[58,81],"and":[59,67,82,95,117,149],"radiotherapy;":[62],"one":[63,68,85,96],"was":[64,69,86,97],"within":[66,139],"outside":[71,125],"radiation":[73],"field":[74,129],"a":[76,88,99],"patient":[77,89,112],"radiotherapy,":[84],"combination":[92],"chemotherapy":[93,115],"alone,":[94,116],"normal":[100],"control.":[101],"No":[102],"abnormal":[103,145],"mitoses":[104,122],"found":[106],"control":[109],"only":[118],"two":[119],"30":[121],"radiotherapy":[128,140,166],"abnormal.":[131,143],"However,":[132],"most":[133,159],"cells":[134],"(49-88%)":[135],"five":[137],"fields":[141],"Typically,":[144],"karyotypes":[146],"pseudodiploid":[148],"contained":[150],"multiple":[151],"balanced":[152],"rearrangements,":[153],"which":[155],"reciprocal":[156],"translocations":[157],"common.":[160],"data":[162],"indicate":[163],"that":[164],"used":[167],"induces":[172],"extensive,":[173],"sustained":[174],"abnormalities":[176],"vivo":[178],"fibroblasts.":[181]},"counts_by_year":[{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}