{"id":"https://openalex.org/W2066535385","doi":"https://doi.org/10.1002/cmdc.201300525","title":"Binding Mode and Structure\u2013Activity Relationships around Direct Inhibitors of the Nrf2\u2013Keap1 Complex","display_name":"Binding Mode and Structure\u2013Activity Relationships around Direct Inhibitors of the Nrf2\u2013Keap1 Complex","publication_year":2014,"publication_date":"2014-02-06","ids":{"openalex":"https://openalex.org/W2066535385","doi":"https://doi.org/10.1002/cmdc.201300525","mag":"2066535385","pmid":"https://pubmed.ncbi.nlm.nih.gov/24504667"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201300525","doi":"https://doi.org/10.1002/cmdc.201300525","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201300525","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012022646","display_name":"Eric Jnoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85722119","display_name":"UCB Pharma (Belgium)","ror":"https://ror.org/01n029866","country_code":"BE","type":"company","lineage":["https://openalex.org/I85722119"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Eric Jnoff","raw_affiliation_strings":["UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium). eric.jnoff@ucb.com","UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium). eric.jnoff@ucb.com","institution_ids":["https://openalex.org/I85722119"]},{"raw_affiliation_string":"UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)","institution_ids":["https://openalex.org/I85722119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101924020","display_name":"Claudia Albrecht","orcid":"https://orcid.org/0009-0005-6045-9360","observed_orcids":["https://orcid.org/0009-0005-6045-9360"]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudia Albrecht","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103439885","display_name":"John J. Barker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John J. Barker","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004541248","display_name":"Oliver Barker","orcid":"https://orcid.org/0009-0000-5662-7046","observed_orcids":["https://orcid.org/0009-0000-5662-7046"]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver Barker","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105159095","display_name":"Edward Beaumont","orcid":"https://orcid.org/0000-0003-4813-1141","observed_orcids":["https://orcid.org/0000-0003-4813-1141"]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edward Beaumont","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033256342","display_name":"Steven M. Bromidge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven Bromidge","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056994477","display_name":"Frederick A. Brookfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frederick Brookfield","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066064981","display_name":"Mark Brooks","orcid":"https://orcid.org/0000-0003-2614-6115","observed_orcids":["https://orcid.org/0000-0003-2614-6115"]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Brooks","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012043006","display_name":"Christian Bubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christian Bubert","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076379106","display_name":"Tom Ceska","orcid":"https://orcid.org/0000-0002-7200-9528","observed_orcids":["https://orcid.org/0000-0002-7200-9528"]},"institutions":[{"id":"https://openalex.org/I4210134054","display_name":"UCB Pharma (United Kingdom)","ror":"https://ror.org/03428qp74","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210134054","https://openalex.org/I85722119"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tom Ceska","raw_affiliation_strings":["UCB Pharma, UCB NewMedicines, 208 Bath Road, Slough, Berkshire SL1 3WE (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCB Pharma, UCB NewMedicines, 208 Bath Road, Slough, Berkshire SL1 3WE (UK)","institution_ids":["https://openalex.org/I4210134054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014701876","display_name":"Vincent Corden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Corden","raw_affiliation_strings":["CEM Microwave Technology Ltd. 2 Middle Slade, Buckingham, Buckinghamshire MK18 1WA (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEM Microwave Technology Ltd. 2 Middle Slade, Buckingham, Buckinghamshire MK18 1WA (UK)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Graham Dawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham Dawson","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008302110","display_name":"St\u00e9phanie Duclos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephanie Duclos","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053732146","display_name":"Tara Fryatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tara Fryatt","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006086038","display_name":"Christophe G\u00e9nicot","orcid":"https://orcid.org/0000-0002-8468-6681","observed_orcids":["https://orcid.org/0000-0002-8468-6681"]},"institutions":[{"id":"https://openalex.org/I85722119","display_name":"UCB Pharma (Belgium)","ror":"https://ror.org/01n029866","country_code":"BE","type":"company","lineage":["https://openalex.org/I85722119"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christophe Genicot","raw_affiliation_strings":["UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)","institution_ids":["https://openalex.org/I85722119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035646517","display_name":"\u00c9milie Jigorel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85722119","display_name":"UCB Pharma (Belgium)","ror":"https://ror.org/01n029866","country_code":"BE","type":"company","lineage":["https://openalex.org/I85722119"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Emilie Jigorel","raw_affiliation_strings":["UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)","institution_ids":["https://openalex.org/I85722119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jason Kwong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason Kwong","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010540445","display_name":"Rosemary Maghames","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rosemary Maghames","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015892102","display_name":"Innocent Mushi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Innocent Mushi","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Pike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Pike","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025107478","display_name":"Zara A. Sands","orcid":"https://orcid.org/0000-0001-5830-6246","observed_orcids":["https://orcid.org/0000-0001-5830-6246"]},"institutions":[{"id":"https://openalex.org/I85722119","display_name":"UCB Pharma (Belgium)","ror":"https://ror.org/01n029866","country_code":"BE","type":"company","lineage":["https://openalex.org/I85722119"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Zara A. Sands","raw_affiliation_strings":["UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)","institution_ids":["https://openalex.org/I85722119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Myron A. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Myron A. Smith","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045701288","display_name":"Christopher C. Stimson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher C. Stimson","raw_affiliation_strings":["Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ (UK)","institution_ids":["https://openalex.org/I4210148098"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090623250","display_name":"Jean\u2010Philippe Courade","orcid":"https://orcid.org/0000-0001-6722-2263","observed_orcids":["https://orcid.org/0000-0001-6722-2263"]},"institutions":[{"id":"https://openalex.org/I85722119","display_name":"UCB Pharma (Belgium)","ror":"https://ror.org/01n029866","country_code":"BE","type":"company","lineage":["https://openalex.org/I85722119"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean\u2010Philippe Courade","raw_affiliation_strings":["UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCB Pharma, UCB NewMedicines, Chemin du Foriest, 1420 Braine-l'Alleud (Belgium)","institution_ids":["https://openalex.org/I85722119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012022646"],"corresponding_institution_ids":["https://openalex.org/I85722119"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":4.4062,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.96154314,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"4","first_page":"699","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10464","display_name":"Crystal structures of chemical compounds","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.765999972820282},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7950000166893005},{"id":"https://openalex.org/keywords/binding-mode","display_name":"binding mode","score":0.6159999966621399},{"id":"https://openalex.org/keywords/x-ray-crystal-structure","display_name":"X-ray crystal structure","score":0.7409999966621399},{"id":"https://openalex.org/keywords/co-crystal-structure","display_name":"co-crystal structure","score":0.6809999942779541},{"id":"https://openalex.org/keywords/ligand-orientation","display_name":"ligand orientation","score":0.640999972820282},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.42800000309944153},{"id":"https://openalex.org/keywords/isoindole-derivatives","display_name":"isoindole derivatives","score":0.4269999861717224},{"id":"https://openalex.org/keywords/tetrahydroisoquinoline-derivatives","display_name":"tetrahydroisoquinoline derivatives","score":0.8640000224113464},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.5450000166893005},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.7697365283966064},{"id":"https://openalex.org/C2778237882","wikidata":"https://www.wikidata.org/wiki/Q211433","display_name":"Cyclohexane","level":2,"score":0.6386821269989014},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6372911930084229},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5694042444229126},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5203258991241455},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4713427722454071},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4665284752845764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11306238174438477},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0904543399810791},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08581268787384033},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072019","descriptor_name":"Kelch-Like ECH-Associated Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cmdc.201300525","doi":"https://doi.org/10.1002/cmdc.201300525","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201300525","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:24504667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24504667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:dora:psi_8909","doi":null,"is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:8909","pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1482023004","https://openalex.org/W1617942550","https://openalex.org/W1767659454","https://openalex.org/W1967440435","https://openalex.org/W2009517899","https://openalex.org/W2018918340","https://openalex.org/W2019172653","https://openalex.org/W2055285423","https://openalex.org/W2057950283","https://openalex.org/W2061034644","https://openalex.org/W2062145087","https://openalex.org/W2081058334","https://openalex.org/W2107505658","https://openalex.org/W2115338196","https://openalex.org/W2117551116","https://openalex.org/W2118898883","https://openalex.org/W2135716022","https://openalex.org/W2141982524","https://openalex.org/W2146883699","https://openalex.org/W2161220011","https://openalex.org/W2171742547","https://openalex.org/W2950440212"],"related_works":["https://openalex.org/W792250969","https://openalex.org/W1596122908","https://openalex.org/W2941112307","https://openalex.org/W4411851902","https://openalex.org/W3135372416","https://openalex.org/W2788576255","https://openalex.org/W2995707483","https://openalex.org/W4210341009","https://openalex.org/W4385740601","https://openalex.org/W2055240611"],"abstract_inverted_index":{"An":[0],"X-ray":[1,19],"crystal":[2,20],"structure":[3,21],"of":[4,31,47,58,63],"Kelch-like":[5],"ECH-associated":[6],"protein":[7],"(Keap1)":[8],"co-crystallised":[9],"with":[10],"(1S,2R)-2-[(1S)-1-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-carbonyl]cyclohexane-1-carboxylic":[11],"acid":[12],"(compound":[13],"(S,R,S)-1":[14,35],"a)":[15],"was":[16,41,53],"obtained.":[17],"This":[18],"provides":[22],"breakthrough":[23],"experimental":[24],"evidence":[25],"for":[26],"the":[27,32,38,48,56,59,72],"true":[28],"binding":[29,65],"mode":[30,66],"hit":[33],"compound":[34],"a,":[36],"as":[37],"ligand":[39],"orientation":[40],"found":[42],"to":[43,68],"differ":[44],"from":[45],"that":[46],"initial":[49],"docking":[50],"model,":[51],"which":[52],"available":[54],"at":[55],"start":[57],"project.":[60],"Crystallographic":[61],"elucidation":[62],"this":[64],"helped":[67],"focus":[69],"and":[70,78],"drive":[71],"drug":[73],"design":[74],"process":[75],"more":[76],"effectively":[77],"efficiently.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
