{"id":"https://openalex.org/W2066523967","doi":"https://doi.org/10.1111/j.1398-9995.2008.01656.x","title":"Airway remodeling is correlated with obstruction in children with severe asthma","display_name":"Airway remodeling is correlated with obstruction in children with severe asthma","publication_year":2008,"publication_date":"2008-04-03","ids":{"openalex":"https://openalex.org/W2066523967","doi":"https://doi.org/10.1111/j.1398-9995.2008.01656.x","mag":"2066523967","pmid":"https://pubmed.ncbi.nlm.nih.gov/18394127"},"language":"en","primary_location":{"id":"doi:10.1111/j.1398-9995.2008.01656.x","doi":"https://doi.org/10.1111/j.1398-9995.2008.01656.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.2008.01656.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022997643","display_name":"Isabelle Tillie\u2010Leblond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Tillie\u2010Leblond","raw_affiliation_strings":["Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille, France","Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800921988"]},{"raw_affiliation_string":"Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800921988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066530416","display_name":"Jacques de BLIC","orcid":"https://orcid.org/0000-0002-6908-9985","observed_orcids":["https://orcid.org/0000-0002-6908-9985"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J. De Blic","raw_affiliation_strings":["Universite\u0301 Paris Descartes; Assistance Publique des Ho\u0302pitaux de Paris, Service de Pneumologie et d\u2019Allergologie pe\u0301diatriques, Ho\u0302pital Necker-Enfants Malades, Paris","Assistance Publique des H\u00f4pitaux de Paris, Service de Pneumologie et d'Allergologie p\u00e9diatriques, H\u00f4pital Necker-Enfants Malades, Paris","Universit\u00e9 Paris Descartes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite\u0301 Paris Descartes; Assistance Publique des Ho\u0302pitaux de Paris, Service de Pneumologie et d\u2019Allergologie pe\u0301diatriques, Ho\u0302pital Necker-Enfants Malades, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Assistance Publique des H\u00f4pitaux de Paris, Service de Pneumologie et d'Allergologie p\u00e9diatriques, H\u00f4pital Necker-Enfants Malades, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088600150","display_name":"Francis Jaubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Jaubert","raw_affiliation_strings":["Service d\u2019Anatomopathologie, Ho\u0302pital Necker-Enfants Malades, Paris, France","Service d'Anatomopathologie, H\u00f4pital Necker-Enfants Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019Anatomopathologie, Ho\u0302pital Necker-Enfants Malades, Paris, France","institution_ids":["https://openalex.org/I1288880153"]},{"raw_affiliation_string":"Service d'Anatomopathologie, H\u00f4pital Necker-Enfants Malades, Paris, France","institution_ids":["https://openalex.org/I1288880153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003191308","display_name":"Beno\u00eet Wallaert","orcid":"https://orcid.org/0000-0002-2075-4315","observed_orcids":["https://orcid.org/0000-0002-2075-4315"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Wallaert","raw_affiliation_strings":["Unite\u0301 INSERM U 774, Institut Pasteur de Lille, Lille","Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 INSERM U 774, Institut Pasteur de Lille, Lille","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800921988"]},{"raw_affiliation_string":"Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800921988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002879812","display_name":"Pierre Scheinmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Scheinmann","raw_affiliation_strings":["Universite\u0301 Paris Descartes; Assistance Publique des Ho\u0302pitaux de Paris, Service de Pneumologie et d\u2019Allergologie pe\u0301diatriques, Ho\u0302pital Necker-Enfants Malades, Paris","Assistance Publique des H\u00f4pitaux de Paris, Service de Pneumologie et d'Allergologie p\u00e9diatriques, H\u00f4pital Necker-Enfants Malades, Paris","Universit\u00e9 Paris Descartes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite\u0301 Paris Descartes; Assistance Publique des Ho\u0302pitaux de Paris, Service de Pneumologie et d\u2019Allergologie pe\u0301diatriques, Ho\u0302pital Necker-Enfants Malades, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Assistance Publique des H\u00f4pitaux de Paris, Service de Pneumologie et d'Allergologie p\u00e9diatriques, H\u00f4pital Necker-Enfants Malades, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058455342","display_name":"Philippe Gosset","orcid":"https://orcid.org/0000-0002-4043-6429","observed_orcids":["https://orcid.org/0000-0002-4043-6429"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Gosset","raw_affiliation_strings":["Unite\u0301 INSERM U 774, Institut Pasteur de Lille, Lille","Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 INSERM U 774, Institut Pasteur de Lille, Lille","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800921988"]},{"raw_affiliation_string":"Unit\u00e9 INSERM U 774, Institut Pasteur de Lille, Lille","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2800921988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066530416"],"corresponding_institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4387156284"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":11.1916,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.98665909,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"63","issue":"5","first_page":"533","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.9750000238418579},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.7739999890327454},{"id":"https://openalex.org/keywords/airway-smooth-muscle","display_name":"airway smooth muscle","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mucous-glands","display_name":"mucous glands","score":0.7139999866485596},{"id":"https://openalex.org/keywords/myosin-light-chain-kinase","display_name":"myosin light chain kinase","score":0.921999990940094},{"id":"https://openalex.org/keywords/vessel-density","display_name":"vessel density","score":0.6809999942779541},{"id":"https://openalex.org/keywords/bronchial-obstruction","display_name":"bronchial obstruction","score":0.7680000066757202},{"id":"https://openalex.org/keywords/endobronchial-biopsy","display_name":"bronchial biopsy","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8101916313171387},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6758813858032227},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.6332279443740845},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6045892834663391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5058209896087646},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47833940386772156},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.4552653133869171},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.4459444582462311},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.413242906332016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.346457302570343},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34600183367729187},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.18672162294387817},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1832006871700287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09295225143432617},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1398-9995.2008.01656.x","doi":"https://doi.org/10.1111/j.1398-9995.2008.01656.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.2008.01656.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:18394127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18394127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1971618831","https://openalex.org/W1975847731","https://openalex.org/W1976911328","https://openalex.org/W1979914322","https://openalex.org/W1981146638","https://openalex.org/W1987492687","https://openalex.org/W1988277233","https://openalex.org/W1992989755","https://openalex.org/W1999780808","https://openalex.org/W2005473631","https://openalex.org/W2014913927","https://openalex.org/W2016025974","https://openalex.org/W2018399596","https://openalex.org/W2021743459","https://openalex.org/W2042027156","https://openalex.org/W2044625455","https://openalex.org/W2045827836","https://openalex.org/W2048327405","https://openalex.org/W2051646880","https://openalex.org/W2053444611","https://openalex.org/W2074142512","https://openalex.org/W2086839127","https://openalex.org/W2093025649","https://openalex.org/W2097165445","https://openalex.org/W2100457204","https://openalex.org/W2102175857","https://openalex.org/W2104537618","https://openalex.org/W2107725463","https://openalex.org/W2111608431","https://openalex.org/W2112162404","https://openalex.org/W2118180042","https://openalex.org/W2118304778","https://openalex.org/W2118462450","https://openalex.org/W2118676765","https://openalex.org/W2121311328","https://openalex.org/W2124723617","https://openalex.org/W2129379317","https://openalex.org/W2130434435","https://openalex.org/W2131758520","https://openalex.org/W2131770075","https://openalex.org/W2132372821","https://openalex.org/W2133437309","https://openalex.org/W2143238483","https://openalex.org/W2146463187","https://openalex.org/W2147740548","https://openalex.org/W2147935423","https://openalex.org/W2159170610","https://openalex.org/W2160896282","https://openalex.org/W2172154734","https://openalex.org/W2172645804","https://openalex.org/W2188764126","https://openalex.org/W2312397711","https://openalex.org/W2604596332"],"related_works":["https://openalex.org/W2014913927","https://openalex.org/W4200441801","https://openalex.org/W2131758520","https://openalex.org/W4309412544","https://openalex.org/W1976434950","https://openalex.org/W2759170953","https://openalex.org/W1955987395","https://openalex.org/W4253512069","https://openalex.org/W7164007227","https://openalex.org/W2399651434"],"abstract_inverted_index":{"BACKGROUND:":[0],"Severe":[1],"asthma":[2,52],"may":[3],"involve":[4],"an":[5,246],"irreversible":[6],"obstructive":[7,43,64,71,76,267],"pattern,":[8,268],"and":[9,53,68,102,114,117,123,135,143,162,209,218,253],"structural":[10],"changes":[11],"in":[12,22,36,85,171,183,240,248,263],"bronchial":[13,110,286],"airways":[14],"are":[15,238,260,276],"believed":[16],"to":[17,32],"play":[18],"a":[19,81,97],"key":[20],"role":[21],"this":[23],"context.":[24],"The":[25],"aim":[26],"of":[27,48,92,99,145,152,164,179,224,235,251,256,285],"the":[28,93,222,254,257,283],"present":[29,239],"study":[30],"was":[31,78,181],"compare":[33],"airway":[34,119,236],"remodeling":[35,237],"severe":[37,51,243],"asthmatic":[38],"children":[39,49,241,264],"with":[40,50,62,175,192,221,242,265,278],"or":[41],"without":[42,70],"pattern.":[44],"METHODS:":[45],"Two":[46],"groups":[47],"persistent":[54,63,266],"symptoms,":[55],"5-14":[56],"years":[57],"old":[58],"were":[59,169],"included,":[60],"15":[61],"pattern":[65,72,77],"(group":[66,73],"O)":[67],"10":[69],"N).":[74],"Persistent":[75],"defined":[79],"as":[80],"forced":[82],"expiratory":[83],"volume":[84],"1":[86],"s":[87],"(FEV(1))":[88],"less":[89],"than":[90],"80%":[91],"predicted":[94],"value":[95],"after":[96,106],"course":[98],"systemic":[100],"corticosteroids":[101],"no":[103],"significant":[104],"improvement":[105],"bronchodilator.":[107],"We":[108],"examined":[109],"biopsies":[111],"by":[112],"pathological":[113],"immunochemical":[115],"methods":[116],"quantified":[118],"smooth":[120],"muscle":[121,137],"(ASM)":[122],"mucus":[124],"gland":[125],"areas,":[126],"reticular":[127],"basement":[128],"membrane":[129],"(RBM)":[130],"thickening,":[131],"distance":[132,223],"between":[133],"ASM":[134,153,193,252],"RBM,":[136],"light":[138],"chain":[139],"kinase":[140],"(MLCK)":[141],"expression":[142,158,202,211],"number":[144,163],"vessels":[146,165],"(CD31":[147],"expression).":[148],"RESULTS:":[149],"Surface":[150],"area":[151,194,250],"(P":[154,159,166,186],"=":[155,160,167,187,196,199,204,207,213,216,227,230],"0.009),":[156],"MLCK":[157,201],"0.03)":[161],"0.0008)":[168],"increased":[170],"group":[172,176,184],"O":[173,185],"compared":[174],"N.":[177],"Distance":[178],"RBM-ASM":[180,225],"shorter":[182],"0.007).":[188,231],"FEV(1)":[189],"negatively":[190],"correlated":[191,220],"(r":[195,203,212,226],"-0.6;":[197],"P":[198,206,215,229],"0.002),":[200],"-0.45;":[205],"0.02)":[208],"CD31":[210],"-0.7;":[214],"0.0003),":[217],"positively":[219],"0.5;":[228],"CONCLUSIONS:":[232],"Structural":[233],"abnormalities":[234],"asthma.":[244],"Only":[245],"increase":[247],"surface":[249],"density":[255],"vascular":[258],"network":[259],"more":[261],"pronounced":[262],"while":[269],"RBM":[270],"thickening":[271],"is":[272],"similar.":[273],"These":[274],"results":[275],"concordant":[277],"longitudinal":[279],"studies":[280],"which":[281],"emphasize":[282],"precocity":[284],"obstruction.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}