{"id":"https://openalex.org/W2066433792","doi":"https://doi.org/10.1002/ana.410250107","title":"Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients","display_name":"Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2066433792","doi":"https://doi.org/10.1002/ana.410250107","mag":"2066433792","pmid":"https://pubmed.ncbi.nlm.nih.gov/2913928"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410250107","doi":"https://doi.org/10.1002/ana.410250107","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410250107","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002412468","display_name":"Ernest W. Willoughby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["CA","NZ"],"is_corresponding":true,"raw_author_name":"E. W. Willoughby","raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, Canada","D. W. Paty, Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada","Department of Medicine, University of Auckland, Auckland, New Zealand","Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","E. W. Willoughby, Department of Medicine, University of Auckland, Auckland, New Zealand","Imaging Research Center, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"D. W. Paty, Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Medicine, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"E. W. Willoughby, Department of Medicine, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Imaging Research Center, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010325246","display_name":"E. Grochowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"E. Grochowski","raw_affiliation_strings":["Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","Imaging Research Center, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Imaging Research Center, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091339933","display_name":"D. K. B. Li","orcid":"https://orcid.org/0000-0003-4017-020X","observed_orcids":["https://orcid.org/0000-0003-4017-020X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D. K. B. Li","raw_affiliation_strings":["Department of Diagnostic Radiology, University of British Columbia, Vancouver, BC, Canada","Imaging Research Center, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Radiology, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Imaging Research Center, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686685","display_name":"Jo\u00ebl Oger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Oger","raw_affiliation_strings":["Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113667849","display_name":"L. F. Kastrukoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L. F. Kastrukoff","raw_affiliation_strings":["Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112147259","display_name":"Donald W. Paty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["CA","NZ"],"is_corresponding":true,"raw_author_name":"D. W. Paty","raw_affiliation_strings":["D. W. Paty, Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada","Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","E. W. Willoughby, Department of Medicine, University of Auckland, Auckland, New Zealand","Imaging Research Center, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D. W. Paty, Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"E. W. Willoughby, Department of Medicine, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Imaging Research Center, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002412468","https://openalex.org/A5112147259"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I154130895"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":19.8771,"has_fulltext":false,"cited_by_count":253,"citation_normalized_percentile":{"value":0.99697218,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"1","first_page":"43","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/lesion-shrinkage","display_name":"lesion shrinkage","score":0.8040000200271606},{"id":"https://openalex.org/keywords/demyelinated-plaques","display_name":"demyelinated plaques","score":0.7379999756813049},{"id":"https://openalex.org/keywords/white-matter-lesions","display_name":"white matter lesions","score":0.7300000190734863},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.3449999988079071},{"id":"https://openalex.org/keywords/treatment-evaluation","display_name":"treatment evaluation","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.9346399903297424},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8752954006195068},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7709575891494751},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.6905134320259094},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6825090646743774},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.6606914401054382},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5323002338409424},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5225995182991028},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.4841190278530121},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.44207990169525146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3196601867675781},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2471393346786499},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410250107","doi":"https://doi.org/10.1002/ana.410250107","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410250107","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:2913928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2913928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W140761365","https://openalex.org/W1957098930","https://openalex.org/W1965152885","https://openalex.org/W1971104775","https://openalex.org/W2000871104","https://openalex.org/W2005422050","https://openalex.org/W2016357044","https://openalex.org/W2040490704","https://openalex.org/W2057119898","https://openalex.org/W2062152350","https://openalex.org/W2063059050","https://openalex.org/W2085206678","https://openalex.org/W2112165124","https://openalex.org/W2127649301","https://openalex.org/W2131387237","https://openalex.org/W2141417847","https://openalex.org/W2150012525","https://openalex.org/W2154766201","https://openalex.org/W2313884663","https://openalex.org/W2343858431","https://openalex.org/W2345650156","https://openalex.org/W2413584507","https://openalex.org/W2421653516"],"related_works":["https://openalex.org/W2071746150","https://openalex.org/W2154766201","https://openalex.org/W1971030447","https://openalex.org/W2626205268","https://openalex.org/W2403422769","https://openalex.org/W2344583856","https://openalex.org/W2085730152","https://openalex.org/W2142846397","https://openalex.org/W4389467028","https://openalex.org/W1982881050"],"abstract_inverted_index":{"A":[0],"prospective":[1],"study":[2],"of":[3,9,35,42,50,55,105,135,146,152,202,215,219],"serial":[4],"magnetic":[5],"resonance":[6],"(MR)":[7],"scans":[8],"the":[10,36,51,56,59,132,150,159,165,172,180,187,199,212],"brain":[11],"was":[12],"carried":[13],"out":[14],"every":[15],"2":[16],"weeks":[17,87],"for":[18],"4":[19,86],"to":[20,139],"6":[21],"months":[22],"in":[23,47,84,119,143,149,155,158,177,207],"9":[24,37],"patients":[25,38,57,123,157],"with":[26],"mild,":[27],"clinically":[28],"definite,":[29],"relapsing/remitting":[30],"multiple":[31],"sclerosis":[32],"(MS).":[33],"Six":[34],"developed":[39],"a":[40,76,81,93,114],"total":[41],"12":[43],"asymptomatic":[44,107,122,156],"new":[45,67,106,169],"lesions":[46,74,108,170,193,206,222],"various":[48],"parts":[49],"brain.":[52],"In":[53],"none":[54],"were":[58],"changes":[60],"on":[61],"MR":[62,73,137],"scan":[63],"accompanied":[64],"by":[65,186],"relevant":[66],"neurological":[68],"symptoms":[69],"or":[70,174,217],"signs.":[71],"New":[72],"had":[75],"characteristic":[77,181],"temporal":[78],"profile,":[79],"reaching":[80],"maximum":[82],"size":[83],"approximately":[85],"before":[88],"gradually":[89],"shrinking,":[90],"usually":[91],"leaving":[92],"small":[94,188],"residual":[95,189],"abnormality":[96],"indistinguishable":[97],"from":[98],"chronic":[99,208],"MS":[100,111,147,209],"lesions.":[101],"The":[102,129],"frequent":[103],"occurrence":[104],"indicates":[109],"that":[110,164,179,191,198],"may":[112,210],"be":[113],"more":[115,218],"active":[116,221],"process":[117],"even":[118],"mildly":[120],"affected":[121],"than":[124],"has":[125],"been":[126],"previously":[127],"realized.":[128],"results":[130],"emphasize":[131],"potential":[133],"importance":[134],"using":[136],"scanning":[138],"measure":[140],"disease":[141],"activity":[142],"laboratory":[144],"studies":[145],"and":[148,167,197],"assessment":[151],"treatment,":[153],"particularly":[154],"early":[160],"stages.":[161],"We":[162],"suggest":[163],"expanding":[166],"contracting":[168],"are":[171],"basic":[173],"primary":[175],"lesion":[176],"MS,":[178],"demyelinated":[182],"plaque":[183],"is":[184],"represented":[185],"area":[190],"these":[192,220],"shrink":[194],"down":[195],"to,":[196],"typical":[200],"collection":[201],"scattered":[203],"white":[204],"matter":[205],"represent":[211],"accumulated":[213],"residua":[214],"dozens":[216],"occurring":[223],"over":[224],"many":[225],"years.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}