{"id":"https://openalex.org/W2066247493","doi":"https://doi.org/10.1002/j.1550-8528.1999.tb00394.x","title":"Miglitol (BAY m 1099) Treatment of Diabetic Hypothalamic\u2010Dietary Obese Rats Improves Islet Response to Glucose","display_name":"Miglitol (BAY m 1099) Treatment of Diabetic Hypothalamic\u2010Dietary Obese Rats Improves Islet Response to Glucose","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2066247493","doi":"https://doi.org/10.1002/j.1550-8528.1999.tb00394.x","mag":"2066247493","pmid":"https://pubmed.ncbi.nlm.nih.gov/10023734"},"language":"en","primary_location":{"id":"doi:10.1002/j.1550-8528.1999.tb00394.x","doi":"https://doi.org/10.1002/j.1550-8528.1999.tb00394.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1550-8528.1999.tb00394.x","pdf_url":null,"source":{"id":"https://openalex.org/S68541908","display_name":"Obesity Research","issn_l":"1071-7323","issn":["1071-7323","1550-8528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109658615","display_name":"Kathleen V. Axen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathleen V. Axen","raw_affiliation_strings":["Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York 11210, USA. kaxen@brooklyn.cuny.edu","Department of Health and Nutrition Sciences and Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York 11210, USA. kaxen@brooklyn.cuny.edu","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I83041322"]},{"raw_affiliation_string":"Department of Health and Nutrition Sciences and Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I83041322"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xue Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Li","raw_affiliation_strings":["Department of Health and Nutrition Sciences and Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Nutrition Sciences and Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I83041322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032957137","display_name":"Anthony J. Sclafani","orcid":"https://orcid.org/0000-0002-3282-0068","observed_orcids":["https://orcid.org/0000-0002-3282-0068"]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Sclafani","raw_affiliation_strings":["Department of Health and Nutrition Sciences and Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Nutrition Sciences and Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I83041322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109658615"],"corresponding_institution_ids":["https://openalex.org/I174216632","https://openalex.org/I83041322"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.20509747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"1","first_page":"83","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/miglitol","display_name":"miglitol","score":1.0},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibitors","display_name":"alpha-glucosidase inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hypothalamic-obesity","display_name":"hypothalamic obesity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.6439999938011169},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.4180000126361847},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.8059999942779541},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.847000002861023},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/high-fat-sucrose-diet","display_name":"high-fat sucrose diet","score":0.5860000252723694},{"id":"https://openalex.org/keywords/food-deprivation","display_name":"food deprivation","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9291569590568542},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9211974740028381},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.742285966873169},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6511194109916687},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.5794951915740967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5578229427337646},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5463148355484009},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5397807359695435},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.40557658672332764}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014697","descriptor_name":"Ventromedial Hypothalamic Nucleus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017485","descriptor_name":"1-Deoxynojirimycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D050112","descriptor_name":"Imino Pyranoses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/j.1550-8528.1999.tb00394.x","doi":"https://doi.org/10.1002/j.1550-8528.1999.tb00394.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1550-8528.1999.tb00394.x","pdf_url":null,"source":{"id":"https://openalex.org/S68541908","display_name":"Obesity Research","issn_l":"1071-7323","issn":["1071-7323","1550-8528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research","raw_type":"journal-article"},{"id":"pmid:10023734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10023734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309102","display_name":"City University of New York","ror":"https://ror.org/00453a208"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W760312520","https://openalex.org/W1669682803","https://openalex.org/W1945591267","https://openalex.org/W1964661186","https://openalex.org/W1996951300","https://openalex.org/W2021233703","https://openalex.org/W2029579844","https://openalex.org/W2050064865","https://openalex.org/W2059557519","https://openalex.org/W2060036178","https://openalex.org/W2069350859","https://openalex.org/W2072563786","https://openalex.org/W2072577318","https://openalex.org/W2075773439","https://openalex.org/W2076611214","https://openalex.org/W2077375633","https://openalex.org/W2100624249","https://openalex.org/W2135236802","https://openalex.org/W2147333898","https://openalex.org/W2157865424","https://openalex.org/W2179036052","https://openalex.org/W2184815980","https://openalex.org/W2338594981","https://openalex.org/W2408507678","https://openalex.org/W4212888272"],"related_works":["https://openalex.org/W1964661186","https://openalex.org/W2020098163","https://openalex.org/W2085674151","https://openalex.org/W2036757159","https://openalex.org/W1975487133","https://openalex.org/W2014788231","https://openalex.org/W2081923945","https://openalex.org/W2083473645","https://openalex.org/W2144530064","https://openalex.org/W4405722953"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"well-absorbed":[2],"alpha-glucosidase":[3],"inhibitor,":[4],"miglitol":[5,172],"(BAY":[6],"m":[7],"1099),":[8],"was":[9,197],"included":[10],"in":[11,95,134,169,178,226],"the":[12,46],"diets":[13,54],"of":[14,45,64,77,158,180],"hypothalamic-dietary":[15],"obese":[16],"diabetic":[17,113,119,167],"rats":[18,40,120,143,164,182],"to":[19,23,72,131,155,176,191,212],"investigate":[20],"its":[21],"ability":[22],"improve":[24,209],"glycemia":[25],"and":[26,49,57,111,126,149,202],"thereby":[27],"reverse":[28],"glucotoxic":[29],"effects":[30,216],"on":[31,186,217],"islet":[32,187,210,218],"secretory":[33,129,153,189,195],"response.":[34],"RESEARCH":[35],"METHODS":[36],"AND":[37],"PROCEDURES:":[38],"Female":[39],"received":[41],"bilateral":[42],"electrolytic":[43],"lesions":[44],"ventromedial":[47],"hypothalamus":[48],"were":[50,59,70,87,107],"fed":[51],"high-fat,":[52],"sucrose-supplemented":[53],"until":[55],"hyperinsulinemia":[56],"hyperglycemia":[58,201],"observed":[60],"after":[61],"3":[62,83],"hours":[63],"food":[65,96],"deprivation":[66],"(nonfed).":[67],"Diabetic":[68],"animals":[69],"assigned":[71],"miglitol-treated":[73,142],"(40":[74],"mg/100":[75],"g":[76],"diet)":[78],"or":[79,100,104,165,223],"untreated":[80,112,118,166],"groups":[81],"for":[82,89],"weeks;":[84],"pancreatic":[85],"islets":[86,139],"isolated":[88,116],"incubation":[90],"experiments.":[91],"RESULTS:":[92],"No":[93],"differences":[94],"intake,":[97],"body":[98],"weights,":[99],"nonfed":[101],"plasma":[102,179],"glucose":[103,135,213],"insulin":[105,124,128,152,188,204],"levels":[106,174],"seen":[108],"between":[109],"treated":[110,181],"rats.":[114],"Islets":[115],"from":[117,141,161],"showed":[121,144],"elevated":[122],"basal":[123,147],"release":[125,148],"no":[127,184],"response":[130,154,196],"an":[132],"elevation":[133],"concentration.":[136],"In":[137],"contrast,":[138],"obtained":[140,160],"more":[145],"normal":[146,162],"a":[150],"significant":[151],"glucose.":[156,192],"Incubation":[157],"islets,":[159],"control":[163],"rats,":[168],"media":[170],"containing":[171],"at":[173],"estimated":[175],"exist":[177],"had":[183],"effect":[185],"responses":[190],"DISCUSSION:":[193],"Islet":[194],"improved":[198],"despite":[199,229],"continued":[200],"severe":[203],"resistance.":[205],"Miglitol":[206],"treatment":[207],"may":[208],"sensitivity":[211],"either":[214],"through":[215],"metabolism":[219],"requiring":[220],"prolonged":[221],"exposure":[222],"by":[224],"improvement":[225],"postmeal":[227],"glycemia,":[228],"persistent":[230],"hyperglycemia.":[231]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
