{"id":"https://openalex.org/W2066058593","doi":"https://doi.org/10.1002/hep.20822","title":"Telomerase Antagonists GRN163 and GRN163L Inhibit Tumor Growth and Increase Chemosensitivity of Human Hepatoma *","display_name":"Telomerase Antagonists GRN163 and GRN163L Inhibit Tumor Growth and Increase Chemosensitivity of Human Hepatoma *","publication_year":2005,"publication_date":"2005-08-19","ids":{"openalex":"https://openalex.org/W2066058593","doi":"https://doi.org/10.1002/hep.20822","mag":"2066058593","pmid":"https://pubmed.ncbi.nlm.nih.gov/16114043"},"language":"en","primary_location":{"id":"doi:10.1002/hep.20822","doi":"https://doi.org/10.1002/hep.20822","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.20822","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044834289","display_name":"Meta W. Djojosubroto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Meta W. Djojosubroto","raw_affiliation_strings":["Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111899982","display_name":"Allison C. Chin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison C. Chin","raw_affiliation_strings":["Geron Corporation, Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geron Corporation, Menlo Park, CA","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110528003","display_name":"Ning Fei Go","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Go","raw_affiliation_strings":["Geron Corporation, Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geron Corporation, Menlo Park, CA","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032677355","display_name":"Sonja Schaetzlein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sonja Schaetzlein","raw_affiliation_strings":["Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002183557","display_name":"Michael Peter Manns","orcid":"https://orcid.org/0000-0002-4485-8856","observed_orcids":["https://orcid.org/0000-0002-4485-8856"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael P. Manns","raw_affiliation_strings":["Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011251007","display_name":"Sergei M Gryaznov","orcid":"https://orcid.org/0009-0004-4743-8592","observed_orcids":["https://orcid.org/0009-0004-4743-8592"]},"institutions":[{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei Gryaznov","raw_affiliation_strings":["Geron Corporation, Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geron Corporation, Menlo Park, CA","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026652295","display_name":"Calvin B. Harley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calvin B. Harley","raw_affiliation_strings":["Geron Corporation, Menlo Park, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geron Corporation, Menlo Park, CA","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053296448","display_name":"K. Lenhard Rudolph","orcid":"https://orcid.org/0000-0002-4839-2862","observed_orcids":["https://orcid.org/0000-0002-4839-2862"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lenhard K. Rudolph","raw_affiliation_strings":["Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany","fax: (49) 511-532-6998"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"fax: (49) 511-532-6998","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053296448"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":6.8056,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.97401519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"5","first_page":"1127","last_page":"1136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-inhibitors","display_name":"telomerase inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/grn163l","display_name":"GRN163L","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.7770000100135803},{"id":"https://openalex.org/keywords/telomere-dysfunction","display_name":"telomere dysfunction","score":0.777999997138977},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9369999766349792},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/doxorubicin-sensitivity","display_name":"doxorubicin sensitivity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.9300000071525574},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.7912863492965698},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.6356534957885742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5715270042419434},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5683329701423645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5661613941192627},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5382236242294312},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.5229580998420715},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4411904811859131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09368360042572021},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.05056318640708923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000705","descriptor_name":"Anaphase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.20822","doi":"https://doi.org/10.1002/hep.20822","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.20822","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:16114043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16114043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1483245334","https://openalex.org/W1521209045","https://openalex.org/W1538980175","https://openalex.org/W1573467049","https://openalex.org/W1613006671","https://openalex.org/W1968396912","https://openalex.org/W1970891016","https://openalex.org/W1983673827","https://openalex.org/W1992430278","https://openalex.org/W1998663807","https://openalex.org/W1998901490","https://openalex.org/W1999611844","https://openalex.org/W1999796994","https://openalex.org/W2012002712","https://openalex.org/W2012573722","https://openalex.org/W2020086762","https://openalex.org/W2027779909","https://openalex.org/W2030976397","https://openalex.org/W2054145511","https://openalex.org/W2058108472","https://openalex.org/W2060423420","https://openalex.org/W2067598739","https://openalex.org/W2072585523","https://openalex.org/W2077951123","https://openalex.org/W2081193579","https://openalex.org/W2084969545","https://openalex.org/W2085716751","https://openalex.org/W2086907907","https://openalex.org/W2090979450","https://openalex.org/W2098437774","https://openalex.org/W2103172804","https://openalex.org/W2104733074","https://openalex.org/W2121955345","https://openalex.org/W2122740168","https://openalex.org/W2126407488","https://openalex.org/W2145344158","https://openalex.org/W2148013194","https://openalex.org/W2153960365","https://openalex.org/W2154224729","https://openalex.org/W2159819769","https://openalex.org/W2166704790","https://openalex.org/W2169743209","https://openalex.org/W2400933137","https://openalex.org/W2611787617","https://openalex.org/W4210973123","https://openalex.org/W6631148826","https://openalex.org/W6678742446","https://openalex.org/W6681701561","https://openalex.org/W6684908068"],"related_works":["https://openalex.org/W1452976926","https://openalex.org/W3009164101","https://openalex.org/W2247199183","https://openalex.org/W2148013194","https://openalex.org/W2132882668","https://openalex.org/W2103172804","https://openalex.org/W1968960900","https://openalex.org/W7100476677","https://openalex.org/W2125343208","https://openalex.org/W2023833929"],"abstract_inverted_index":{"Most":[0],"cancer":[1,42],"cells":[2],"have":[3],"an":[4],"immortal":[5],"growth":[6,108,137],"capacity":[7,27,229],"as":[8,58],"a":[9,35,110,208],"consequence":[10],"of":[11,15,28,48,53,64,82,122,147,152,170,197,206,212,220,230,238],"telomerase":[12,32,103,214],"reactivation.":[13],"Inhibition":[14],"this":[16,239],"enzyme":[17],"leads":[18],"to":[19,78,129,167,225,242],"increased":[20,156,194],"telomere":[21,144,148],"dysfunction,":[22,149],"which":[23],"limits":[24],"the":[25,46,62,123,130,159,204,213,227,236],"proliferative":[26,228],"tumor":[29,106,136,240],"cells;":[30],"thus,":[31],"inhibition":[33],"represents":[34],"potentially":[36],"safe":[37],"and":[38,56,68,89,100,105,115,120,155,174],"universal":[39],"target":[40],"for":[41,61,217],"treatment.":[43],"We":[44],"evaluated":[45],"potential":[47],"two":[49],"thio-phosphoramidate":[50],"oligonucleotide":[51],"inhibitors":[52],"telomerase,":[54],"GRN163":[55,67,99],"GRN163L,":[57,126,207],"drug":[59],"candidates":[60],"treatment":[63,160,219],"human":[65,84,221],"hepatoma.":[66,222],"GRN163L":[69,101,164,193,232],"were":[70],"tested":[71],"in":[72,91,109,113,116,138,158,178,185],"preclinical":[73],"studies":[74,95],"using":[75],"systemic":[76,218],"administration":[77,165],"treat":[79],"flank":[80],"xenografts":[81],"different":[83],"hepatoma":[85,180],"cell":[86,107,153,181],"lines":[87],"(Hep3B":[88],"Huh7)":[90],"nude":[92],"mice.":[93],"The":[94,118],"showed":[96,189],"that":[97,190],"both":[98,179],"inhibited":[102],"activity":[104],"dose-dependent":[111],"manner":[112],"vitro":[114,186],"vivo.":[117],"potency":[119],"efficacy":[121],"lipid-conjugated":[124],"antagonist,":[125],"was":[127,140],"superior":[128],"nonlipidated":[131],"parent":[132],"compound,":[133],"GRN163.":[134],"Impaired":[135],"vivo":[139],"associated":[141],"with":[142,192],"critical":[143],"shortening,":[145],"induction":[146],"reduced":[150],"rate":[151],"proliferation,":[154],"apoptosis":[157],"groups.":[161],"In":[162,183,199,223],"vitro,":[163],"led":[166],"higher":[168],"prevalence":[169],"chromosomal":[171],"telomere-free":[172],"ends":[173],"DNA":[175],"damage":[176],"foci":[177],"lines.":[182],"addition,":[184],"chemosensitivity":[187],"assay":[188],"pretreatment":[191],"doxorubicin":[195],"sensitivity":[196,237],"Hep3B.":[198],"conclusion,":[200],"our":[201],"data":[202],"support":[203],"development":[205],"novel":[209],"lipidated":[210],"conjugate":[211],"inhibitor":[215],"GRN163,":[216],"addition":[224],"limiting":[226],"hepatoma,":[231],"might":[233],"also":[234],"increase":[235],"type":[241],"conventional":[243],"chemotherapy.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
