{"id":"https://openalex.org/W2066042612","doi":"https://doi.org/10.3109/03008207.2013.823954","title":"Age-related analysis of structural, biochemical and mechanical properties of the porcine mitral heart valve leaflets","display_name":"Age-related analysis of structural, biochemical and mechanical properties of the porcine mitral heart valve leaflets","publication_year":2013,"publication_date":"2013-07-19","ids":{"openalex":"https://openalex.org/W2066042612","doi":"https://doi.org/10.3109/03008207.2013.823954","mag":"2066042612","pmid":"https://pubmed.ncbi.nlm.nih.gov/23869611"},"language":"en","primary_location":{"id":"doi:10.3109/03008207.2013.823954","doi":"https://doi.org/10.3109/03008207.2013.823954","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03008207.2013.823954","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110151611","display_name":"Vladimir A. Kasyanov","orcid":"https://orcid.org/0000-0003-4411-1020","observed_orcids":["https://orcid.org/0000-0003-4411-1020"]},"institutions":[{"id":"https://openalex.org/I201787326","display_name":"Riga Technical University","ror":"https://ror.org/00twb6c09","country_code":"LV","type":"education","lineage":["https://openalex.org/I201787326"]},{"id":"https://openalex.org/I4210126294","display_name":"Riga Stradi\u0146\u0161 University","ror":"https://ror.org/03nadks56","country_code":"LV","type":"education","lineage":["https://openalex.org/I4210126294"]}],"countries":["LV"],"is_corresponding":true,"raw_author_name":"Vladimir Kasyanov","raw_affiliation_strings":["Riga Stradins University, Laboratory of Biomechanics , Riga , Latvia ","Riga Technical University, Institute of Biomaterials and Biomechanics\nRigaLatvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Riga Stradins University, Laboratory of Biomechanics , Riga , Latvia ","institution_ids":["https://openalex.org/I4210126294"]},{"raw_affiliation_string":"Riga Technical University, Institute of Biomaterials and Biomechanics\nRigaLatvia","institution_ids":["https://openalex.org/I201787326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065061483","display_name":"Ricardo A. Moreno\u2010Rodriguez","orcid":"https://orcid.org/0000-0002-5420-4231","observed_orcids":["https://orcid.org/0000-0002-5420-4231"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo A. Moreno-Rodriguez","raw_affiliation_strings":["Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina Charleston, SCUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina Charleston, SCUSA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075724265","display_name":"M\u0101rti\u0146\u0161 Kal\u0113js","orcid":"https://orcid.org/0000-0003-0409-5222","observed_orcids":["https://orcid.org/0000-0003-0409-5222"]},"institutions":[{"id":"https://openalex.org/I4210126294","display_name":"Riga Stradi\u0146\u0161 University","ror":"https://ror.org/03nadks56","country_code":"LV","type":"education","lineage":["https://openalex.org/I4210126294"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Martins Kalejs","raw_affiliation_strings":["Riga Stradins University, Laboratory of Biomechanics RigaLatvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Riga Stradins University, Laboratory of Biomechanics RigaLatvia","institution_ids":["https://openalex.org/I4210126294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068923598","display_name":"Iveta Ozolanta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126294","display_name":"Riga Stradi\u0146\u0161 University","ror":"https://ror.org/03nadks56","country_code":"LV","type":"education","lineage":["https://openalex.org/I4210126294"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Iveta Ozolanta","raw_affiliation_strings":["Riga Stradins University, Laboratory of Biomechanics RigaLatvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Riga Stradins University, Laboratory of Biomechanics RigaLatvia","institution_ids":["https://openalex.org/I4210126294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068150507","display_name":"P\u0113teris Stradi\u0146\u0161","orcid":"https://orcid.org/0000-0002-7419-6136","observed_orcids":["https://orcid.org/0000-0002-7419-6136"]},"institutions":[{"id":"https://openalex.org/I4210126294","display_name":"Riga Stradi\u0146\u0161 University","ror":"https://ror.org/03nadks56","country_code":"LV","type":"education","lineage":["https://openalex.org/I4210126294"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Peteris Stradins","raw_affiliation_strings":["Riga Stradins University, Laboratory of Biomechanics RigaLatvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Riga Stradins University, Laboratory of Biomechanics RigaLatvia","institution_ids":["https://openalex.org/I4210126294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103526914","display_name":"Xuejun Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuejun Wen","raw_affiliation_strings":["Clemson/MUSC Bioengineering Program, Department of Bioengineering, Clemson University ClemsonSC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clemson/MUSC Bioengineering Program, Department of Bioengineering, Clemson University ClemsonSC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102794379","display_name":"Hai Yao","orcid":"https://orcid.org/0009-0008-7817-3485","observed_orcids":["https://orcid.org/0009-0008-7817-3485"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Yao","raw_affiliation_strings":["Clemson/MUSC Bioengineering Program, Department of Bioengineering, Clemson University ClemsonSC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clemson/MUSC Bioengineering Program, Department of Bioengineering, Clemson University ClemsonSC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"last","author":{"id":null,"display_name":"Vladimir Mironov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210142333","display_name":"Centro de Tecnologia da Informa\u00e7\u00e3o Renato Archer","ror":"https://ror.org/044nfga98","country_code":"BR","type":"government","lineage":["https://openalex.org/I4210142333","https://openalex.org/I4210151455"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Vladimir Mironov","raw_affiliation_strings":["Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina Charleston, SCUSA;Division of 3D Technologies, Renato Archer Center for Information Technology, Campinas SPBrazil","Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina\nCharleston, SCUSA","Division of 3D Technologies, Renato Archer Center for Information Technology, Campinas\nSPBrazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina Charleston, SCUSA;Division of 3D Technologies, Renato Archer Center for Information Technology, Campinas SPBrazil","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210142333"]},{"raw_affiliation_string":"Advanced Tissue Biofabrication Center, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina\nCharleston, SCUSA","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Division of 3D Technologies, Renato Archer Center for Information Technology, Campinas\nSPBrazil","institution_ids":["https://openalex.org/I4210142333"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5110151611"],"corresponding_institution_ids":["https://openalex.org/I201787326","https://openalex.org/I4210126294"],"apc_list":null,"apc_paid":null,"fwci":2.9465,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91906942,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"54","issue":"6","first_page":"394","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.2151000052690506,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.11100000143051147,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-heart-valves","display_name":"porcine valves","score":0.7979999780654907},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9909999966621399},{"id":"https://openalex.org/keywords/collagen-content","display_name":"collagen content","score":0.9570000171661377},{"id":"https://openalex.org/keywords/collagen-fibril-diameter","display_name":"collagen fibril diameter","score":0.9539999961853027},{"id":"https://openalex.org/keywords/collagen-cross-linking","display_name":"collagen cross-linking","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tensile-properties","display_name":"tensile properties","score":0.8379999995231628},{"id":"https://openalex.org/keywords/valvulogenesis","display_name":"valvulogenesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/heart-valve-tissue-engineering","display_name":"heart valve tissue engineering","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.7508049607276917},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.7200690507888794},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.6009396314620972},{"id":"https://openalex.org/C2992610612","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Cardiac valve","level":2,"score":0.5627357959747314},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5432372093200684},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.522135317325592},{"id":"https://openalex.org/C3019161014","wikidata":"https://www.wikidata.org/wiki/Q26868","display_name":"Collagen fibril","level":2,"score":0.48315876722335815},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47873398661613464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4570056200027466},{"id":"https://openalex.org/C3019522753","wikidata":"https://www.wikidata.org/wiki/Q2657962","display_name":"Fetal heart","level":4,"score":0.4532814621925354},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.43333059549331665},{"id":"https://openalex.org/C2910217441","wikidata":"https://www.wikidata.org/wiki/Q126888","display_name":"Mechanical heart","level":2,"score":0.41218259930610657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3696519136428833},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3589179515838623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34671974182128906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24352559447288513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13004830479621887},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.11356508731842041},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.11062812805175781},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008943","descriptor_name":"Mitral Valve","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D008943","descriptor_name":"Mitral Valve","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008943","descriptor_name":"Mitral Valve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008943","descriptor_name":"Mitral Valve","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/03008207.2013.823954","doi":"https://doi.org/10.3109/03008207.2013.823954","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03008207.2013.823954","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},{"id":"pmid:23869611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23869611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective tissue research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W127092093","https://openalex.org/W1506625266","https://openalex.org/W1700545894","https://openalex.org/W1963483392","https://openalex.org/W1970802524","https://openalex.org/W1974346231","https://openalex.org/W1975796152","https://openalex.org/W1977673248","https://openalex.org/W1988071888","https://openalex.org/W2001269659","https://openalex.org/W2005893713","https://openalex.org/W2012046824","https://openalex.org/W2013578008","https://openalex.org/W2019967921","https://openalex.org/W2022544791","https://openalex.org/W2028999521","https://openalex.org/W2030634957","https://openalex.org/W2034648034","https://openalex.org/W2035371717","https://openalex.org/W2039817227","https://openalex.org/W2040321633","https://openalex.org/W2040330595","https://openalex.org/W2066264704","https://openalex.org/W2074872410","https://openalex.org/W2080028071","https://openalex.org/W2091139873","https://openalex.org/W2097274284","https://openalex.org/W2099327671","https://openalex.org/W2108819369","https://openalex.org/W2117328083","https://openalex.org/W2128348913","https://openalex.org/W2143595182","https://openalex.org/W2146151765","https://openalex.org/W2154707001","https://openalex.org/W2160251803","https://openalex.org/W2162677827","https://openalex.org/W2163483931","https://openalex.org/W2165161204","https://openalex.org/W2174906208","https://openalex.org/W2320685067","https://openalex.org/W2335685106","https://openalex.org/W2426406560","https://openalex.org/W2473346553"],"related_works":["https://openalex.org/W2260607294","https://openalex.org/W2030634957","https://openalex.org/W3123242703","https://openalex.org/W127092093","https://openalex.org/W1964541789","https://openalex.org/W2582360622","https://openalex.org/W3046310934","https://openalex.org/W111381937","https://openalex.org/W2145718561","https://openalex.org/W2154889502"],"abstract_inverted_index":{"The":[0,50,92,109],"aim":[1],"of":[2,16,41,53,79,94,117,133,139,150,154,157,174],"this":[3],"study":[4],"was":[5,35],"to":[6,27,169],"assess":[7],"structural":[8,152],"and":[9,19,119,136,162],"biochemical":[10],"differences":[11,112],"in":[12,25,83,99,113,128,177],"the":[13,17,38,54,77,100,105,114,131,137,151,171],"extracellular":[14],"matrix":[15],"fetal":[18,69,89,101,118],"adult":[20,55,84,106,120],"porcine":[21,42,121],"mitral":[22,43],"heart":[23,44,56,70,85,90,102,107,122,158,178],"valves":[24,45,86,123,159],"relation":[26],"their":[28],"mechanical":[29],"characteristics.":[30],"Using":[31],"tensile":[32],"tests":[33],"it":[34],"demonstrated":[36,75],"that":[37,76],"material":[39,115,155],"properties":[40,116,156],"progressively":[46],"change":[47],"with":[48,68,88,126],"age.":[49],"collagen":[51,80,95,129,134,140],"content":[52],"valve,":[57],"as":[58,66],"estimated":[59],"by":[60],"hydroxyproline":[61],"assay,":[62],"increases":[63,127],"three":[64],"times":[65],"compared":[67,87],"valves.":[71,91],"Transmission":[72],"electron":[73],"microscopy":[74],"diameter":[78,132],"fibrils":[81,135],"increased":[82],"level":[93,138,173],"cross-linking":[96],"is":[97],"lower":[98],"valve":[103,179],"than":[104],"valve.":[108],"reported":[110],"age":[111],"were":[124],"associated":[125],"content,":[130],"cross-linking.":[141],"These":[142],"data":[143],"lay":[144],"a":[145],"foundation":[146],"for":[147],"systematic":[148],"elucidation":[149],"determinants":[153],"during":[160],"embryonic":[161],"postnatal":[163],"valvulogenesis.":[164],"They":[165],"are":[166],"also":[167],"essential":[168],"define":[170],"desirable":[172],"tissue":[175,180],"maturation":[176],"engineering.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}