{"id":"https://openalex.org/W2066018141","doi":"https://doi.org/10.1371/journal.pgen.0030076","title":"Drosophila SETDB1 Is Required for Chromosome 4 Silencing","display_name":"Drosophila SETDB1 Is Required for Chromosome 4 Silencing","publication_year":2007,"publication_date":"2007-05-07","ids":{"openalex":"https://openalex.org/W2066018141","doi":"https://doi.org/10.1371/journal.pgen.0030076","mag":"2066018141","pmid":"https://pubmed.ncbi.nlm.nih.gov/17500594","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1866353"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.0030076","doi":"https://doi.org/10.1371/journal.pgen.0030076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0030076","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030076&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030076&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072764639","display_name":"Carole Seum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Carole Seum","raw_affiliation_strings":["Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088402030","display_name":"Emanuela Reo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emanuela Reo","raw_affiliation_strings":["Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102946696","display_name":"Hongzhuang Peng","orcid":"https://orcid.org/0000-0003-0273-0034","observed_orcids":["https://orcid.org/0000-0003-0273-0034"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongzhuang Peng","raw_affiliation_strings":["The Wistar Institute, Philadelphia, Pennsylvania, United States of America","The Wistar Institute, Philadelphia, Pennsylvania, United States of#N#                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"The Wistar Institute, Philadelphia, Pennsylvania, United States of#N#                    America","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039435168","display_name":"Frank J. Rauscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank J Rauscher","raw_affiliation_strings":["The Wistar Institute, Philadelphia, Pennsylvania, United States of America","The Wistar Institute, Philadelphia, Pennsylvania, United States of#N#                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"The Wistar Institute, Philadelphia, Pennsylvania, United States of#N#                    America","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025108877","display_name":"Pierre Spierer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pierre Spierer","raw_affiliation_strings":["Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073333620","display_name":"S\u00e9verine Bontron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"S\u00e9verine Bontron","raw_affiliation_strings":["Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073333620"],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":3.8081,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.95092619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"5","first_page":"e76","last_page":"e76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.2289000004529953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setdb1","display_name":"SETDB1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/h3k9-methylation","display_name":"H3K9 methylation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/h3k9-methyltransferase","display_name":"H3K9 methyltransferase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/euchromatin","display_name":"euchromatin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pericentromeric-heterochromatin","display_name":"pericentromeric heterochromatin","score":0.796999990940094},{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.6740000247955322},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8207886815071106},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.7543108463287354},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.6660090088844299},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.6613130569458008},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.6537775993347168},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.5990575551986694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5837624073028564},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.5361810326576233},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39879462122917175},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.39768528938293457},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3514127731323242},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3358469605445862},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17445984482765198},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.06063380837440491}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020043","descriptor_name":"Genes, Essential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022041","descriptor_name":"Euchromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pgen.0030076","doi":"https://doi.org/10.1371/journal.pgen.0030076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0030076","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030076&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2622297","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1866353","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1866353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1866353","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:17500594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17500594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:unige:9833","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:9833","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 1553-7390","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.9346","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.9346","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7f/27/PLoS_Genet_2007_May_11_3(5)_e76.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d85990312deb4b22aa1bd8ef7da16c6c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d85990312deb4b22aa1bd8ef7da16c6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 3, Iss 5, p e76 (2007)","raw_type":"article"},{"id":"pmh:oai:unige.ch:aou:unige:9833","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:9833","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-7390","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.0030076","doi":"https://doi.org/10.1371/journal.pgen.0030076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0030076","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030076&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2066018141.pdf","grobid_xml":"https://content.openalex.org/works/W2066018141.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W56897296","https://openalex.org/W160853306","https://openalex.org/W1509466986","https://openalex.org/W1542248960","https://openalex.org/W1551315794","https://openalex.org/W1575147957","https://openalex.org/W1603793127","https://openalex.org/W1974193054","https://openalex.org/W1976616140","https://openalex.org/W1978358191","https://openalex.org/W1982409009","https://openalex.org/W1982461647","https://openalex.org/W1985180051","https://openalex.org/W1985634754","https://openalex.org/W1987687886","https://openalex.org/W1998921153","https://openalex.org/W2001256904","https://openalex.org/W2001488804","https://openalex.org/W2001653133","https://openalex.org/W2002698073","https://openalex.org/W2003250545","https://openalex.org/W2005442184","https://openalex.org/W2018420071","https://openalex.org/W2018438969","https://openalex.org/W2018758172","https://openalex.org/W2022936129","https://openalex.org/W2024295388","https://openalex.org/W2024576630","https://openalex.org/W2026501344","https://openalex.org/W2029733458","https://openalex.org/W2034946403","https://openalex.org/W2034957983","https://openalex.org/W2035133243","https://openalex.org/W2035424802","https://openalex.org/W2038940861","https://openalex.org/W2042971816","https://openalex.org/W2053291659","https://openalex.org/W2067255200","https://openalex.org/W2067487392","https://openalex.org/W2067547992","https://openalex.org/W2079637100","https://openalex.org/W2081337865","https://openalex.org/W2082259303","https://openalex.org/W2086574165","https://openalex.org/W2086618705","https://openalex.org/W2104870341","https://openalex.org/W2105073128","https://openalex.org/W2110318729","https://openalex.org/W2110618077","https://openalex.org/W2122338068","https://openalex.org/W2122774081","https://openalex.org/W2126625694","https://openalex.org/W2130809217","https://openalex.org/W2138162912","https://openalex.org/W2138373011","https://openalex.org/W2141452262","https://openalex.org/W2145432449","https://openalex.org/W2151026121","https://openalex.org/W2152326948","https://openalex.org/W2154071588","https://openalex.org/W2155149522","https://openalex.org/W2160419242","https://openalex.org/W2162296692","https://openalex.org/W2162958692","https://openalex.org/W2166164324","https://openalex.org/W2167334533","https://openalex.org/W2417114846"],"related_works":["https://openalex.org/W7095859420","https://openalex.org/W2094415799","https://openalex.org/W2171405275","https://openalex.org/W2972284926","https://openalex.org/W3112172763","https://openalex.org/W7096790682","https://openalex.org/W4389786790","https://openalex.org/W2239737106","https://openalex.org/W118950510","https://openalex.org/W2146463666"],"abstract_inverted_index":{"Histone":[0],"H3":[1],"lysine":[2],"9":[3],"(H3K9)":[4],"methylation":[5,21,33],"is":[6,17,54,78,88,106,128,160],"associated":[7],"with":[8],"gene":[9,87],"repression":[10,132],"and":[11,38,71,93,114,119,151,156],"heterochromatin":[12],"formation.":[13],"In":[14],"Drosophila,":[15],"SU(VAR)3-9":[16],"responsible":[18,30,107],"for":[19,31,90,108,120,130,164],"H3K9":[20,32,58,112,121,145],"mainly":[22,97],"at":[23,34,39,98],"pericentric":[24],"heterochromatin.":[25],"However,":[26],"the":[27,40,75,81,111,152],"histone":[28],"methyltransferases":[29],"euchromatic":[35],"sites,":[36],"telomeres,":[37],"peculiar":[41],"Chromosome":[42,99,124,137,154,165],"4":[43,155,166],"have":[44],"not":[45],"yet":[46],"been":[47],"identified.":[48],"Here,":[49],"we":[50],"show":[51],"that":[52,85,94,104,147,158],"DmSETDB1":[53,95,105,127,142],"involved":[55],"in":[56,117],"nonpericentric":[57],"methylation.":[59],"Analysis":[60],"of":[61,110,133],"two":[62],"DmSetdb1":[63],"alleles":[64],"generated":[65],"by":[66],"homologous":[67],"recombination,":[68],"a":[69,144],"deletion,":[70],"an":[72,161],"allele":[73],"where":[74],"3HA":[76],"tag":[77],"fused":[79],"to":[80],"endogenous":[82],"DmSetdb1,":[83],"reveals":[84],"this":[86],"essential":[89,162],"fly":[91],"viability":[92],"localizes":[96],"4.":[100,125,138],"It":[101],"also":[102],"shows":[103,157],"some":[109],"mono-":[113],"dimethyl":[115],"marks":[116],"euchromatin":[118,150],"dimethylation":[122],"on":[123,136],"Moreover,":[126],"required":[129],"variegated":[131],"transgenes":[134],"inserted":[135],"This":[139],"study":[140],"defines":[141],"as":[143],"methyltransferase":[146],"specifically":[148],"targets":[149],"autosomal":[153],"it":[159],"factor":[163],"silencing.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}